Experience

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  Shodhana Laboratories Limited

  • Hyderabad Area, India

  • Scientist

    • May 2015 - Present
    • Hyderabad Area, India

    1) Developing new APIs (Active pharmaceutical Ingredients) and APIs intermediates at R&D to plant scale.2) Designing new schemes for new RFP (requisition for proposals)3) Cost estimation for new RFPs. 4) Planning daily reaction in R&D lab.5) Planning scale up reaction in pilot scale (Process developed projects).6) Cost reduction of existed projects.7) Synthesis of Drug substances Impurities.

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  GVK Biosciences

  • Hyderabad Area, India

  • Associate Scientist

    • May 2006 - Apr 2015
    • Hyderabad Area, India

    1) Synthesis of novel molecules in 50 mg to 100 g & 1 Kg to 5 kg scale (FTE and FFS based) project in cost effective and challenging manner deliver the molecule with in time lines.2) Estimation of RFPs (Requisitions for proposal) with cost effective manner by using (Reaxys, SciFinder) 3) Cost effective novel schemes designing and implementation in our laboratory.4) Characterized the novel molecules by using analytical techniques like NMR, Mass, LCMS, ELSDMS, IR (functional groups)GCMS.5) Designed the new synthetic route for problematic schemes.6) Synthesis of novel molecules drug impurities up to 1 g sale.7) Problem Solving and monitoring of my associates work.8) Synthesis of impurities for API molecules and characterized by using analytical techniques.9) Documentation review related to new products validation. In Lab scale handling reagents & Reactions:10) Handling of Palladium catalyzed reaction like, Wittig reaction, Simmon smith reaction, Decman condensation, Heck Reaction, Suzuki, Stille coupling, Buchwald-Hart wig, Sonogashira reaction.11) Handled Oxidizing reagents: like PCC, PDC IBX, Dess-Martin, KMnO4, MCPBA, H2O2, Purification techniques.Compound distilled under high vacuum and higher temperature, Crystallization, Column chromatography, Co-precipitations, Ion exchange chromatography using resins.  Esterification,12) Handling of toxic reagent for Cyanation like (KCN, NaCN&CuCN), 13) Condensation, Hydrogenation, Bromination, Alkylation and Acylation. 14) Hydride transfer reagents (LAH, SBH, DIBALH, sodiumtriacetoxy borohydride )15) Experienced in Chiral synthesis using chiral auxilleries, chiral reagents and chiral catalyzed reagent (CBS catalyst) D&L Mandalic acid. Di paratoluyl d-tartaric acid, Enzymatic reaction:16) Handled Enzymatic reaction are like selective etherification with novozymes 435, Vinyl acetate.17) Enzymatic ketone reduction used with GDH, NADPH, KRED at specific pH 

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  SANMAR specialty chemicals

  • Chennai Area, India

  • Research Assistant

    • Aug 2005 - May 2006
    • Chennai Area, India

    1) Accelerating research.. 2) Synthesis of new molecule, according to client requirement.3) Peptide synthesis (Acid amine coupling reactions)4) Compounds purifies using various methods (like High vacuum distillation, crystallization, column chromatography, co-precipitation)