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Sergio Castro Reina, Ph.D., is a seasoned materials scientist and engineer with expertise in electrospray, nanotechnology, and materials development. He has worked on various projects, including the development of electrospun materials, gas phase HDX followed by ECD for protein characterization, and the optimization of nonwoven technology. His research experience spans academia and industry, with a focus on innovative applications of materials science. He holds a Doctor of Philosophy degree from Yale University and a Bachelor of Engineering degree from the Engineering School of Seville.

Experience

    • Product Development Scientist
      • Dec 2019 - Present

    • Semifinalist
      • May 2019 - Apr 2020

      Semifinalist of the American-Made Solar Prize with SIGUE, a innovative technology to smartly consume the energy produced by an off-grid solar system that includes weather prediction inputs to manage and optimize energy usage.https://m.youtube.com/watch?v=kSv-iq04GOMhttps://americanmadechallenges.org/solarprize/round2.html

    • Product/Process Development Engineer
      • Dec 2017 - Jul 2019
      • Hudson, OH

      Development and optimization of proprietary nonwoven technology; nozzle optimization; development and scale-up of sub-microfiber-based adhesives, eye patches and face masks for cosmetic applications, and superabsorbent polymer loaded sub-microfibers for incontinence applications; standard operation and validation procedures writing, including update of medical ISO13485(2016)

  • Bioinicia
    • Valencia, España
    • R&D and Product/Process Manager
      • Apr 2016 - Oct 2017
      • Valencia, España

      Development of electrospinning-based products: polymeric fibers, sol-gel, suspension, emulsions, core-shell; encapsulation of bioactive substances such as probiotic, DHA (Omega3), essential oils, etc; fabrication of drug-loaded multi-layered patches for controlled release; scientific publications, patents, and public documents writing.

    • Senior Scientist (PI)
      • Jun 2013 - Apr 2016

      Development and scale up of new generation perovskite-based low cost photovoltaic (PV) cells via electrospray deposition. Design and optimization of multi-nozzle injector and budget management (650k€).External funding: CTA grant awarded (April 2015-Nov. 2016): 560k€.

  • Washington University in St. Louis
    • Chemistry and Biology, Advisors: Michael L. Gross and Robert Blankenship
    • Postdoctoral Associate
      • Jun 2011 - Apr 2013
      • Chemistry and Biology, Advisors: Michael L. Gross and Robert Blankenship

      At WUSTL I worked on characterizing the intramolecular noncovalent interactions of proteins in the gas phase. Specifically, hydrogen bonds and salt bridges between acidic and basic residues by chemical derivation followed by HPLC-nESI-MS (Bruker FTMS-ICR and Waters Synapt G2). Chemical derivatization of the acidic residues into neutral or basic ones disabled salt bridges and enhanced hydrogen bonds respectively, providing key information of each of those noncovalent interactions. This information is important to further develop top-down proteomics and for drugs screenings.

  • Cornell University
    • Chemistry and Chemical Biology, Advisor: Fred W. McLafferty
    • Postdoctoral Associate
      • Nov 2008 - Jun 2011
      • Chemistry and Chemical Biology, Advisor: Fred W. McLafferty

      At Cornell University and during a few productive weeks working with professor Kathrin Breuker at University of Innsbruck I developed gas phase HDX followed by ECD to locate for the first time bends and folds in gas phase proteins (ubiquitin - 8.5kDa - 7+ to 13+ charge states). This technique provides residue level information of key features, bends and folds, to describe the tertiary structure of gas phase proteins. This accurate description is necessary to further develop top-down proteomics and confirms that several conformations are stable in the gas phase during typical experimental times, e.g., a few seconds, indicating that native structure of relatively small proteins is NOT conserved in the gas phase.

    • Peer-reviewed publication
      • Jan 2004 - Feb 2004

      11 publications and 1 patent: 3 first author, 6 second author. 1. Encapsulation by Electrospray. Coating atomization of Probiotic Strains. Inn. Food Sci. and Emerging Tech. 39, 216-222 (2017).2. Electrospinning: Biomedical industrial applications, recent innovations and products. Scale up requirements for industrialization. Book chapter in Electrospun materials for Tissue Engineering and biomedical applications, pp. 57-72, (2017) 3. Novel poly(Ɛ-caprolactone)/gelatin wound dressing prepared by emulsion electrospinning with controlled release capacity of ketoprofen anti-inflammatory drug. Master Sci Eng C Mater Biol Appl. 81, 459-468 (2017). 4. Electrohydrodynamic processes: Non-thermal processes for micro and nano encapsulation. Book chapter in Thermal and nonthermal encapsulation methods. CRC Press (2017). 5. Multi-step evolution of protein conformation on electrospray into the gas phase. Eur. J. Mass Spect. 16, 3, 437-442 (2010). 6. The influence of the tip radius of curvature on the emission of current from an ionic liquid ion source. J. Appl. Phys. 105, 034903 (2009). 7. Effect of liquid properties on electrosprays from externally wetted ionic liquid ion sources. J. Appl. Phys. 102, 049210 (2007). 8. Monoenergetic source of kilodalton ions from Taylor cones of ionic liquids. J. Appl. Phys. 101, 084303 (2007). 9. Taylor cones of ionic liquids from capillary tubes as sources of pure ions: The role of surface tension and electrical conductivity. J. Appl. Phys. 102, 064913 (2007).10. Taylor cones of ionic liquids as ion sources: The role of electrical conductivity and surface tension, in Ionic Liquids: Not Just Solvents Anymore. Oxford University Press, New York, (2007), p. 308. 11. Water based compound Taylor cones held in vacuum: Feasibility and application to colloidal propulsion. Appl. Phys. Lett. 88, 123105 (2006). Patent. Instalación y procedimiento de encapsulación industrial de sustancias termolábiles. ES3548.1 (2016).

Education

  • 2004 - 2008
    Yale University
    Doctor of Philosophy (PhD), Mechanical Engineering
  • 1997 - 2004
    Escuela Superior de Ingenieros Industriales de Sevilla
    Bachelor of Engineering (BEng), Mechanical/Chemical Engineering

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