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Melanie Kardel is a seasoned expert in cell biology, molecular biology, and biotechnology with extensive experience in pluripotent stem cell (PSC) biology, cell differentiation, and product development. She has led multiple projects at Notch Therapeutics and STEMCELL Technologies, and has a strong background in research, product management, and team leadership. She holds a PhD in Genetics from the University of British Columbia and a BSc in Molecular Genetics from the University of Alberta.

Experience

    • Canada
    • Biotechnology Research
    • 1 - 100 Employee
    • Associate Director, PSC Biology
      • Feb 2023 - Sep 2023

      • Led development and optimization of induced pluripotent stem cell (iPSC) differentiation platform for allogeneic immune cell therapy programs. • Acted as PSC subject matter expert on product development project teams, providing strategic input and technical advice.• Generated iPS-derived CD34+ hematopoietic progenitor cells and functional iPS-derived CD8+ αβ T-cells at research and pre-clinical scales. • Liaison with Process Development teams for tech transfer and scale-up of optimized cell differentiation protocols. • Established assays for in-depth characterization and quality assessment of differentiated cell products (e.g. flow cytometry, single cell RNA sequencing, live cell respirometry, functional assays). • Managed external collaborations, evaluated new technologies for potential in-licensing, fostered relationships with Scientific Advisory Board members. • Recruited, built and mentored a team of Scientists and Research Associates.

    • Senior Scientist, PSC Biology
      • Jun 2020 - Mar 2023

    • Canada
    • Biotechnology Research
    • 700 & Above Employee
    • Senior Scientist
      • Oct 2016 - May 2020

      • Responsible for the Pluripotent Stem Cell (PSC) product portfolio including all aspects of new product development and product lifecycle management. • Proposed, developed, commercialized and launched novel products for hPSC maintenance and differentiation; launched multiple major top-selling products. • Identified and partnered with external collaborators for technology assessments, potential in-licensing, and product testing. Participated in international iPS cell therapy organizations. • Supported Quality and Regulatory requirements for cGMP ancillary reagents for cell therapy.• Led cross-functional matrixed project teams on high priority and high visibility projects.• Collaborated with groups across R&D on diverse projects including differentiation, scale-up, cell enrichment, and culture automation.• Subject matter expert in hPSC culture, banking, quality testing, cell-based assay development, and hematopoietic differentiation. Presented externally at conferences and training courses.

    • Scientist
      • May 2012 - Oct 2016

    • Canada
    • Medical Practices
    • 1 - 100 Employee
    • Postdoctoral Researcher
      • Apr 2011 - May 2012

    • Doctoral Student
      • Sep 2003 - Apr 2011

    • Research Technician
      • 2001 - 2003

Education

  • 2003 - 2011
    The University of British Columbia
    Doctor of Philosophy (PhD), Genetics
  • 1997 - 2001
    University of Alberta
    Bachelor of Science (BSc), Molecular Genetics

Suggested Services

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Industry Focus. “Biotechnology Research”

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