Experience

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  Evonetix Ltd

  • United Kingdom
  • Biotechnology Research
  • 100 - 200 Employee

  • Principal Scientist

    • Jan 2023 - Present

  • Senior Scientist

    • Jun 2020 - Jan 2023

    At Evonetix I help to develop a method to synthesise, assemble and error-correct gene-length DNA on a silicon chip within a benchtop device.Some of my responsibilities include: - Planning, risk analysis, execution and management of technical projects,- Technical leadership in areas of interfacial chemistry and electrochemical processes,- Developing functional coatings for DNA attachment and release, compatibility with DNA synthesis conditions, antifouling, - Developing DNA assembly process: design of buffer and operational parameters for controlled release, transport and hybridisation; cell development,- Building and integration of electrochemistry as a capability within the company,- Developing electrochemical approaches to surface analysis, surface modification, molecular quantification and DNA assembly process,- Establishing methods and protocols for MEMS chips surface characterisation and QC,- Mentoring junior staff members, providing technical training.

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  Lightcast Discovery

  • Cambridge, United Kingdom

  • Senior Scientist

    • Jul 2019 - Jun 2020
    • Cambridge, United Kingdom

    Worked towards building a droplet manipulation platform and its application to biochemical assays at a single cell level.- Developed surface coatings for microfluidics enabling droplet generation, emulsion handling, oEWOD functionality and discrete sites for cell adhesion (patterned coatings). - Formulated emulsion composition and provided microfluidic setup solutions to achieve emulsion stability and cell viability.- Conducted cell based fluorescence assays in microdroplets.

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  Base4

  • United Kingdom
  • Research
  • 1 - 100 Employee

  • Senior Scientist

    • Apr 2018 - Jun 2019

  • Research Scientist

    • Jun 2014 - Mar 2018

    Worked towards a novel DNA sequencing technology in an interdisciplinary environment.- Collaborated with physicists, molecular biologists, hardware and software engineers and other chemists to deliver integrated solutions.- Made key contributions to the development of surface coatings for a variety of materials - silica, alumina, ITO, gold - and a range of functions - translocation of DNA through inorganic pores with controlled speed, bioconjugation, antifouling, reversible immobilisation of polymeric beads, microfluidic droplet generation and emulsion handling.- Led team responsible for surface chemistry research and service to other departments.- As Health & Safety Officer I oversaw documentation, protocols implementation, inspections, induction and training.

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  Interdisciplinary Nanoscience Center

  • Aarhus, Denmark

  • Postdoc

    • Mar 2012 - Mar 2014
    • Aarhus, Denmark

    Investigated electrochemistry of hemoglobins and flavohemoglobins and their use as biosensors for reactive oxygen species and NADH.Investigated electrochemistry of heme covalently attached to mixed self-assembled monolayers and reconstituted horseradish peroxidase.

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  University of Southampton

  • Southampton, United Kingdom

  • Research Fellow in Electrochemistry

    • Oct 2006 - Feb 2012
    • Southampton, United Kingdom

    - Participated in collaborative EC projects (Biomednano and 3D-Nanobiodevice) aimed at developing redox enzyme-based implantable biofuel cells - Developed modular surface functionalisation of electrodes using electrochemical and solid phase synthetic chemistry methods - Optimised conjugation chemistries to immobilise redox enzymes, investigated enzyme kinetics.- Researched NADH oxidation on electrodes modified with a library of redox complexes- Collaborated in research on electrodeposition of battery electrolytes, nanostructured electrodes, scanning electrochemical microscopy- Taught courses in physical chemistry, kinetics, error analysis, electrochemistry and electrochemical techniques to undegraduate, postgraduate and professional audiences- Acting group head for one year.

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  National Oceanography Centre

  • Southampton, United Kingdom

  • Research Assistant

    • Nov 2005 - May 2006
    • Southampton, United Kingdom

    Developed hardware and software (Labview environment) for testing rig to evaluate the performance of microelectrode dissolved oxygen sensor under flow conditions. Further developed the sensor for millisecond response time.