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Luke Miles profile image

Luke Miles

Senior Research Fellow at The Florey Institute of Neuroscience and Mental Health
Intro Book
Neuroscientist developing monoclonal and engineered antibody therapies to combat neuroinflammation and dementia.
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Location
Parkville, Victoria, Australia, AU
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Bio

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Luke Miles is a seasoned neuroscientist with 20+ years of experience in developing innovative therapies to combat neuroinflammation and dementia. He holds a PhD in Environmental Chemistry from La Trobe University and has worked at various prestigious institutions, including the Florey Institute, St Vincent's Institute, and the University of Melbourne.

Experience

  • The Florey Institute of Neuroscience and Mental Health
    • Australia
    • Senior Research Fellow
      • Mar 2021 - Present
      • Australia

      Microglia are the rapid-response innate immune cells that nurture and protect the brain. These cells keep the brain in pristine condition for neuronal health by engulfing debris, toxins, and infections, and by supporting and rebuilding damaged synapses. As we age, these cells can become unfit to fulfil these functions, and a self-perpetuating cycle of reduced toxin clearance and neuroinflammation is sustained over the decades from mid-life to old age, often leading to Alzheimer's disease and related dementias. I am working to develop monoclonal and engineered antibody therapies as well as small molecule drugs to stimulate these immune cells. Our aim is to disrupt this neuroinflammatory cycle to prevent widespread neuronal loss and the onset of dementia. Specifically, my work involves:-recombinant receptor expression and purification-monoclonal antibody panning, production and characterisation-multibody engineering-tissue culture-structural biology-small molecule ligand screening-in vivo assay design in unique humanised AD models-ex vivo tissue examination-data analysis, interpretation and publication

  • St Vincent's Institute of Medical Research
    • Fitzroy, Victoria, Australia
    • AD Lead
      • Oct 2008 - Mar 2021
      • Fitzroy, Victoria, Australia

  • University of Melbourne
    • Parkville, Victoria, Australia
    • Adjunct Research Fellow
      • Oct 2005 - Dec 2019
      • Parkville, Victoria, Australia

  • Avipep
    • Parkville, Victoria
    • Consultant antibody engineer
      • Apr 2005 - May 2006
      • Parkville, Victoria

  • Tokyo Metropolitan University
    • Minami-Ohsawa, Tokyo, Japan
    • Japan Society for the Promotion of Science (JSPS) Fellow
      • Oct 2002 - Jun 2004
      • Minami-Ohsawa, Tokyo, Japan

  • La Trobe University
    • Bundoora, Victoria, Australia
    • Honorary Research Fellow
      • Jan 2000 - Jan 2003
      • Bundoora, Victoria, Australia

  • WEHI - The Walter and Eliza Hall Institute
    • Parkville, Victoria, Australia
    • Postdoctoral Research Fellow
      • Feb 2000 - Oct 2002
      • Parkville, Victoria, Australia

Education

  • 1997 - 2001
    La Trobe University
    Doctor of Philosophy - PhD, Environmental Chemistry
  • 1991 - 1995
    La Trobe University
    Bachelor of Science (Hons) 1st class, Physical Chemistry

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