Experience

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  AstraZeneca

  • Cambridge, England, United Kingdom

  • Postdoc Fellow

    • May 2020 - Present
    • Cambridge, England, United Kingdom

    - Diagnostic assay development from proof-of-concept study, feasibility study and validation on clinical samples;- Nanopore sensing of analyte selectively and specifically in complex biomatrix;- Biomarker detection in liquid biopsy samples;- DNA extraction, purification manually or using automated machines such as KingFisher, and downstream analysis using Tape Station and qPCR;- Built knowledge, experience and passion in developing and delivering precision medicine/personalized healthcare to revolutionize the treatment to patients.

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  University of Cambridge

  • Marie Sklodowska-Curie Fellow

    • Dec 2016 - Mar 2020

    - Awarded Marie Sklodowska-Curie Fellowship for 2 years. Wrote the research proposal independently;- Built knowledge and expertise in biomarker-targeted drug development, bioconjugate click chemistry, ADC preparation, characterization and safety, efficacy evaluation in vivo;- Focused on tumour-selective and HER2-targeted delivery with improved safety and efficacy; fluorescent imaging and quantification of tumour tissue with low background in vivo; - Collaborative work on developing novel site-specific ADC, activities including ADC preparation, characterization and safety, efficacy evaluation in normal and HER2-overexpress cancer cells; - Expertise in small molecules, protein and protein-drug conjugates analysis using NMR and LC-MS; evaluation of drug safety and toxicity on cancer cell lines; evaluation of biomarker expression in living/fixed tissues.

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  Peking University

  • Beijing City, China

  • Research Associate

    • Sep 2014 - Sep 2016
    • Beijing City, China

    - Built knowledge and expertise in nanotechnology, cancer biology, molecular biology and chemical biology;- Focused on tumour-targeted protein delivery and subsequential in situ activation with NIR light in living cells and in mice, enabling tumour treatment and imaging with precise spatiotemporal control; - Extensive experience in tissue culture, cancer cell signalling pathway analysis by immunostaining, Western Blot, Flow Cytometry, fluorescence microscope imaging and quantification, handling nanomaterial and bioconjugate chemistry;- Experience in LC-MS analysis, molecular biology, tumour resection from mice xenograft tumour model, tumour tissue sectioning and microscope imaging.