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Dr. Chandra Sekhar Pasula is a seasoned genetic toxicologist with 15+ years of experience in establishing in vitro genotoxicology, cytotoxicology, and cell culture facilities, and leading battery of genotoxicity tests. He holds a PhD in Cancer Biology from Manipal Academy of Higher Education and has worked as a scientist and study director in various organizations, including Palamur Biosciences Pvt Ltd and Jai Research Foundation.

Experience

    • Head-Genetic Toxicology & Microbiology
      • Jun 2009 - Present
      • mahabubnagar

      Established in vitro genotoxicology, cytotoxicology, phototoxicology and cell culture facility (cell bank) in current organization. Study Director in the present battery of genotoxicity test including invivo and invitro tests listed below: •Mutagenicity test using bacterial culture: Bacterial Reverse Mutation Test Using Salmonella typhimuruim and E. coli Strains.•In Vitro Chromosomal Aberration Test by using CHO-K1 Cell Line and Human Lymphocytes.•Cell Gene Mutation Test using CHO-K1 Cell Line •In Vitro Micronucleus test •Mouse Lymphoma Assay•Comet assay•Cytotoxicity assays: MTT assay, Neutral red uptake test, Trypan blue dye exclusion test, •Antimicrobial compounds efficacy testing•In vivo Clastogenicity test conducted in mice: Micronucleus test. •In vivo Chromosomal Aberration Test in Mice.Working as a scientist for:•Bioassays-estrogen receptor (under validation) •Hepatotoxicity assays (under validation) -in vitro phototoxicity test as per OECD 432 using BALB 3T3 cell line •Toxin Neutralization Assay •In Vitro skin absorption •In Vitro skin corrosion: Transcutaneous Electrical Resistance Test (TER)

    • PhD
      • Dec 2013 - Aug 2019
      • India

    • scientist
      • Dec 2007 - May 2009
      • vapi, gujarat

      Jai Research Foundation (JRF) is a GLP certified Contract Research Organization conducting Pre-Clinical Trials in the field of Toxicology and Pharma Services. In JRF, Genotoxicology is one of the Departments evaluating Toxic Effects on genes, conducting studies like AMES, Micro-Nucleus Test, Human Lymphoma Chromosomal Aberrations Test, Cell Gene Mutation. The Department of Genotoxicology comes as a special section in the field of Toxicology.study director for battery of genotoxicology test.study personnel for bioassays, cytotoxicity assaysmicrobiologist

Education

  • Manipal Academy of Higher Education
    Doctor of Philosophy - PhD, Cancer Biology
  • 2004 - 2006
    Sri Venkateswara University
    Master's degree, Microbiology, General

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