Experience

The Francis Crick Institute

• United Kingdom
• Research Services
• 700 & Above Employee

• Group Leader

  • ‏فبراير 2021 - - الحالي



Newnham College

• United Kingdom
• Higher Education
• 1 - 100 Employee

• Junior Research Fellow

  • ‏سبتمبر 2017 - ‏فبراير 2021

  This role is an independent position which provides me the freedom to coordinate and manage my own research programme. I have been exploring the possibilities of extending the gastruloid system to other species, as well as characterising the role of cellular 'niches' in our 3D cell aggregates as a means of differentiating rare cell types. This role is an independent position which provides me the freedom to coordinate and manage my own research programme. I have been exploring the possibilities of extending the gastruloid system to other species, as well as characterising the role of cellular 'niches' in our 3D cell aggregates as a means of differentiating rare cell types.



Department of Genetics, University of Cambridge

• United Kingdom
• Research Services
• 1 - 100 Employee

• Postdoctoral Researcher

  • 2016 - 2017

  Worked to further characterise the 'gastruloid' system, an organoid model of early gastrulation events, using embryonic stem cells. These aggregates of cells are able to self-organise along 3 axes, and differentiate into all 3 germ layers of the early embryo. I performed the bioinformatic analysis of RNA-sequencing datasets and compared this experimental system along a timecourse to developing mouse embryos. This work was done in collaboration, and I was part of the the group of Professor Alfonso Martinez Arias.



University of Cambridge

• United Kingdom
• Research Services
• 700 & Above Employee

• PhD Student

  • ‏سبتمبر 2012 - ‏سبتمبر 2016

  My PhD focussed on how epigenetic factors, which alter how the DNA is packaged, can affect cellular choices using single-cell transcriptional analysis. In particular, I examined how epigenetic regulation and histone acetylation altered cell fate, through changing the degree of transcriptional noise. This was done with Dr Cristina Pina, at the Department of Haematology (now at Department of Genetics). My PhD focussed on how epigenetic factors, which alter how the DNA is packaged, can affect cellular choices using single-cell transcriptional analysis. In particular, I examined how epigenetic regulation and histone acetylation altered cell fate, through changing the degree of transcriptional noise. This was done with Dr Cristina Pina, at the Department of Haematology (now at Department of Genetics).



Cancer Research UK

• United Kingdom
• Research Services
• 1 - 100 Employee

• Scientific Officer

  • 2012 - ‏أكتوبر 2012

  I worked as a Scientific Officer in the lab of Sir Professor Paul Nurse, performing a screen in yeast (S. pombe) for genes that gave rise to alterations in changes to the rate of the cell cycle. I worked as a Scientific Officer in the lab of Sir Professor Paul Nurse, performing a screen in yeast (S. pombe) for genes that gave rise to alterations in changes to the rate of the cell cycle.