The Leslie Lab is working at the interface of physics and biology with a particular interest in quantifying the dynamics of individual molecules. Our research provides insights into the biophysical properties of molecules, cells, and relevant therapeutics with the ultimate goal of propelling quantitative health sciences. We develop single-molecule and single-cell imaging/analysis tools, as well as mathematical models of molecular interactions, to help guide the rational design of new therapeutic molecules and delivery vehicles. These discoveries will elucidate the process of how molecules search for and bind to a target and perform their therapeutic function in a complex living environment, with a particular focus on nucleic acid interactions and advancing genetic medicines. Current projects include: understanding the biophysics of nucleic acid hybridization, understanding the mechanisms of antisense oligonucleotides, protein-protein interactions, and single-molecule activity in whole cells. For more information about our research or career opportunities, please visit our lab websites https://leslielab.msl.ubc.ca/, Sabrina Leslie's PHAS page https://phas.ubc.ca/users/sabrina-leslie, or contact us directly at leslielab [at] msl.ubc.ca.
