Experience

CStone Pharmaceuticals

• China
• Pharmaceutical Manufacturing
• 100 - 200 Employee

• Associate Director for Target Biology and Translational Research

  • Nov 2021 - Present



无锡智康弘义生物科技有限公司（Wuxi Biocity)

• Shanghai, China

• Director for Department of Translational Medicine

  • Oct 2020 - Nov 2021

  1. Establish scientific in vivo strategy and study plans for drug discovery projects and track record of managing small teams and supervising/mentoring scientists. 2. Serve as the in vivo Pharmacology lead on several drug discovery projects for cancer immunotherapy and targeted therapy, and the treatment of IgA Nephropathy. Works within the multi-functional teams to support target identification, validation, drug discovery, and combination therapy 3. Works across the in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across Translational Sciences. Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship and combination strategies. Design and conduct studies for development and validation of biomarker assays fit-for-purpose for clinical trials 4. Develop and characterize new in vivo mouse models including genetically engineered mouse (GEM) models to study biologic mechanisms and support exploration of novel cancer therapeutics. 5. Design and oversee studies to characterize the biological consequences of a given mechanism of action to enable generation of a robust clinical development plan to identify relevant cancer types, target patient population, potential combination strategies and mechanisms of resistance 6. Provide interpretation of model systems in the context of clinical translatability. 7. Generate and be accountable for the necessary Animal Use Protocols that ensures team members comply with all internal policies and regulatory requirements. 8. Drives data interpretation, presentation and documentation of experiments as well as preparation of study reports including drafting in vivo sections of regulatory documents such as IND filings. 9. Possess excellent verbal and written communication skills to thrive in a fast-paced matrix environment. Show less



Zhejiang Vimgreen Pharma

• Hangzhou, Zhejiang, China

• Vice President for Department of Target Biology and Translational Medicine

  • Feb 2019 - Sep 2020

  1. Lead small and large molecule drug discovery projects through lead optimization to candidate selection and IND-enabling studies. Develop and implement biomarker strategies for projects emerging from the discovery pipeline. 2. Serve as the in vitro and in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vitro and in vivo data to enable project stage dependent decisions. 3. Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy. Supervision and guidance of direct reports. Ensure team members comply with all regulatory requirements and internal policies. 4. Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across translational pharmacology. 5. Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis in related diseases, including, but not limited to, oncology, Parkinson and rheumatoid arthritis (RA). 6. Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team. 7. Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment. Presentations at internal, national, and international meetings. 8. Responsible for contribution to relevant biological sections of study reports and regulatory documents i.e. IND filings. Show less



China Medical University

• Taiwan
• Research Services
• 100 - 200 Employee

• Associate Professor for Cancer Biology and Translational Medicine

  • Jan 2015 - Jan 2019

  1. Demonstrate deep scientific and technical expertise to advance our understanding in the fields of cancer therapy, and the treatment of Parkinson and autoimmune diseases 2. Identification and characterization of the basic cellular mechanisms and of new targets governing these related diseases using high content screening and automated analysis of microscopy. Develop and execute on biomarkers strategies for cancer treatment in collaboration with oncologists. 3. Independently design and implement the in vitro and in vivo experiments for efficacy of small-and large- molecule drug candidates that target the adenosine pathways and the tumor metabolic signaling pathways 4. Responsible for establishment and daily management of the laboratory. Provide education and training research for junior faculty, graduate and undergraduate students participating in the related programs 5. Development of recombinant DNA technology, recombinant protein construction and purification. 6. Supervise laboratory research projects conducted by junior faculty, graduate and undergraduate students. Independently apply for the national funding and publish research findings in top-tier journals. 7. Effectively communicate results at internal and external events and proactively contribute to the continued scientific growth in the department. 8. Contribute to a culture that embraces scientific excellence, effectiveness, and team-work Show less



Houston Methodist Research Institute

• Houston, Texas, United States

• Postdoctoral Fellow for Cancer Biology and Translational Medicine

  • Oct 2011 - Dec 2014

  1. Independently design and execute research plans to elucidate the biologic mechanisms on the related signal pathways which target TLR signaling, immune checkpoint signaling (PD-1 and CTLA-4) and cancer metabolic signaling. 2. Based on excellent hands-on lab work, development, characterization, implementation and validation of relevant in vitro cell culture assays and in vivo animal models for identifying novel targets and pathways for further drug discovery in cancer immunotherapy and targeted therapy. 3. Excellent expertise with common immunology techniques, such as immune cell culture, multi-channel flow cytometry, FACS sorting, ELISA, ELISPOT and high-content screening analysis, and the development of recombinant monoclonal antibodies and antibody-based assays 4. Collaborate with clinical teams to implement biomarker studies in clinical studies related to oncology 5. Excellent communication skills, both written and oral, and highly organized in terms of goal setting and achieving for multiple experiments/tasks. Communication of work through internal seminars and team meetings and external conferences 6. Present novel research findings and on-going progress at monthly group meetings and publish scientific peer-reviewed journals in top-tier publications 7. Provide training and supervising graduate students, laboratory technicians and summer interns Show less