Yfke Pasman
Head of Department of Epidemiology, Bioinformatics & Omics, Animal Models and Vaccine Development at Wageningen Bioveterinary Research- Claim this Profile
Click to upgrade to our gold package
for the full feature experience.
-
English Full professional proficiency
-
Dutch Native or bilingual proficiency
-
German Limited working proficiency
-
French Elementary proficiency
Topline Score
Bio
Credentials
-
GCP/GMP/GLP KRC Int. (in progress)
-Mar, 2018- Oct, 2024 -
Graduate Teaching Development Program
University of Guelph
Experience
-
Wageningen Bioveterinary Research
-
Netherlands
-
Research Services
-
100 - 200 Employee
-
Head of Department of Epidemiology, Bioinformatics & Omics, Animal Models and Vaccine Development
-
Jan 2023 - Present
Part of the management team contributing to the organization and supporting researchers Part of the management team contributing to the organization and supporting researchers
-
-
-
-
CCAC ethics subcommittee member
-
Dec 2018 - Present
Developing guidance document on the fundamental principles for the care of animals in science and the conduct of experiments. Developing guidance document on the fundamental principles for the care of animals in science and the conduct of experiments.
-
-
-
Canadian Blood Services
-
Canada
-
Non-profit Organizations
-
700 & Above Employee
-
Postdoctoral Researcher, Ni Lab, St. Michaels Hospital
-
Jan 2020 - Dec 2022
Elucidate mechanisms of antibody mediated immune suppression in an β3-/- model of Fetal Neonatal Alloimmune Thrombocytopenia using Next Generation Sequencing RNA-Seq and in vitro and in vivo functional assays. Background: Canadian Blood Services supported research "Reducing IVIG usage by developing novel prophylaxis and therapies against FNAIT". FNAIT is a relatively common (~1 in 100 live births) disease caused by maternal antibodies against paternally-inherited fetal platelet antigens. These antibodies can cross the placenta and can cause miscarriage and severe bleeding especially in the fetal brain leading to fetal/neonatal death or life-long disability. My research uses a mouse FNAIT model to investigate the pathways involved in FNAIT, and explores the possibility of using antibody-mediated immune suppression as a therapeutic prophylaxis or treatment strategy for the management and prevention of FNAIT. Show less
-
-
-
CCOA Therapeutics Inc./St. Michaels Hospital
-
Toronto, Canada Area
-
Strategic Operations Manager
-
Jan 2020 - Nov 2022
• Support investment and fundraising activities in Canada and China: apply and support applications for government grants and other sources of financial support • Review and advice on third party contract and work proposals; CDMO and CRO selection for IND enabling studies and phase I clinical trials • Research and development: technical and scientific support, IND application preparation (organize CMC, toxicology and other research data), synthesize and evaluate SAM particles for development of medical devices for ITP • Continuous (potential) competitor analysis • Administrative and lab management support; acquisition, train staff, develop quality management system writing SOPs, protocols etc. • Writing patents, grants (for example, 6 COVID-19 grants, Heart and Stroke Foundation; Ontario Institute for Cancer Research, Canadian Blood Services), Animal protocols (ACC), Review Ethics Board (REB) applications, scientific publications and reviews. Show less
-
-
-
St. Michael's Hospital, Ni Lab / CCOA Therapeutics Inc.
-
Toronto, Ontario, Canada
-
Research Associate and Coordinator
-
Sep 2018 - Dec 2019
• Develop antibodies and aptamers targeting biomarkers to modulate hemostasis and thrombosis for potential diagnostic and therapeutic application. • Train undergraduate, graduate, and postdoctoral fellows. Writing grants, patents, animal protocols, SOPs, REB applications, Informed consent forms, scientific publications, and reviews. • Develop antibodies and aptamers targeting biomarkers to modulate hemostasis and thrombosis for potential diagnostic and therapeutic application. • Train undergraduate, graduate, and postdoctoral fellows. Writing grants, patents, animal protocols, SOPs, REB applications, Informed consent forms, scientific publications, and reviews.
-
-
-
Ontario Veterinary College, University of Guelph
-
Canada
-
Higher Education
-
100 - 200 Employee
-
Postdoctoral Research Fellow in Virology and Vaccine Development
-
Mar 2018 - Aug 2018
Research in the department of Pathobiology, Nagy Lab Develop Fowl Adenovirus vaccines Develop assays to study immune responses of chickens to viral infections Research in the department of Pathobiology, Nagy Lab Develop Fowl Adenovirus vaccines Develop assays to study immune responses of chickens to viral infections
-
-
-
Centre for the Commercialization of Antibodies and Biologics (CCAB)
-
Canada
-
Biotechnology
-
MITACS Postdoctoral Fellow, Therapeutic Antibody Development
-
Feb 2017 - Jan 2018
Developed synthetic antibodies for applications in oncology Developed functional immune checkpoint inhibitors Optimized developability of high-affinity binders for selected targets Applied and developed in vitro assays to test affinity and functionality Developed synthetic antibodies for applications in oncology Developed functional immune checkpoint inhibitors Optimized developability of high-affinity binders for selected targets Applied and developed in vitro assays to test affinity and functionality
-
-
-
University of Toronto
-
Canada
-
Higher Education
-
700 & Above Employee
-
Postdoctoral Fellow, Developing Immunocheckpoint Inhibitors
-
Jan 2016 - Jan 2018
Project leader to develop caninized cross-reactive antibodies to treat dog tumors and test the potential value of dogs as a model in oncology Identified potential therapeutic antibodies through phage display in combination with high-throughput screening and sequencing. Developed assays (ELISA, cytoflow, funtional assays to test T cell activation, etc.) to test caninized antibodies Advised International Livestock Institute (ILRI) vaccine development project against East Coast Fever Project leader to develop caninized cross-reactive antibodies to treat dog tumors and test the potential value of dogs as a model in oncology Identified potential therapeutic antibodies through phage display in combination with high-throughput screening and sequencing. Developed assays (ELISA, cytoflow, funtional assays to test T cell activation, etc.) to test caninized antibodies Advised International Livestock Institute (ILRI) vaccine development project against East Coast Fever
-
-
-
University of Guelph
-
Canada
-
Higher Education
-
700 & Above Employee
-
Lecturer Immunology
-
Sep 2015 - Dec 2015
Taught MICR*3230 Immunology I, a 3rd year level undergraduate course, to ~350 students. Developed and presented lectures and exams.Supervised, coached and provided feedback and comments on exams and assignments
-
-
Graduate research associate
-
Jan 2008 - Dec 2015
Developed a vaccine or adjuvant therapy to prevent bovine herpesvirus-1 infection in cattle through antibody engineering and virology, leading to a patent application.Managed, organized and coordinated Kaushik lab including ordering.Involved in grant applications and reviewDeveloped assays to test neutralization efficacy in vitroTested in vivo neutralizing antibody response in bovine calf Improved the understanding of bovine immunogenetics and the development of the bovine neonatal humoral immune system with an objective to strengthen host defense against infectious agents, through analysis of Next Generation Sequencing data, RNA-Seq. Show less
-
-
Graduate teaching associate
-
Sep 2008 - Apr 2014
Organized, presented, mentored and supervised several regular and lab courses MICR*3230Immunology I (6x), MICR*4320/MICR*6423 Immunology II, MICR*4530 Immunology II (3x), MBG*1040 Genetics and Society, BIOL*1040 Biology II, BIOL*2210 Introduction in Cell biology. Providing feedback, guidance and counselling to students enrolled in these courses
-
-
-
Pharmacy Wormer B.V.
-
Wormer, Netherlands
-
Pharmacist
-
2005 - 2006
Management, supervision, guidance, counsel patients, advised physicians, developed and implemented SOPs for ISO-9001-2002 HKZ. Worked as a replacement pharmacist for several months within this time frame Management, supervision, guidance, counsel patients, advised physicians, developed and implemented SOPs for ISO-9001-2002 HKZ. Worked as a replacement pharmacist for several months within this time frame
-
-
-
Pharmacy Wolvega
-
Wolvega, Netherlands
-
Pharmacist
-
2003 - 2005
•Manager of 13 staff, including 10 pharmaceutical technicians, Conducted recruitment, interviews, selection and training of all staff •Excellent communication skills; noticed, communicated and solved problems regarding prescriptions and staff •Increased profit through efficiency; implemented computerized stock management allowing for a better efficiency in direct costs, storage space, work hours •Followed courses on relevant pharmacotherapeutic subjects and management skills •Developed and implemented protocols to certify ISO-9001-2002 HKZ over a one year period •Advised physicians and counseled patients Show less
-
-
-
Friendly Island Pharmacy
-
St. Martin, Dutch Antilles
-
Pharmacist
-
2000 - 2003
•Managed a staff of 6 individuals processing ~250 prescriptions daily •Independently provided medication and advised for the Island of Saba; population of 1100, 1 hospital, 1 general practitioner •Provided about 50 HIV/AIDS patients with medication in consultation with their general practitioner. Keeping up to date with developments in AIDS/Immune research and medication. •Conducted financial administration, purchase and sale, contracts, setting prices •Managed a staff of 6 individuals processing ~250 prescriptions daily •Independently provided medication and advised for the Island of Saba; population of 1100, 1 hospital, 1 general practitioner •Provided about 50 HIV/AIDS patients with medication in consultation with their general practitioner. Keeping up to date with developments in AIDS/Immune research and medication. •Conducted financial administration, purchase and sale, contracts, setting prices
-
-
-
Pharmacy Bathmen
-
Bathmen, Netherlands
-
Pharmacist
-
1996 - 2000
•Organized a complete start up of this pharmacy over a period of 2 years •Supervised a team of 10 pharmaceutical technicians processing 800 prescriptions daily •Communicated with health care providers concerning prescriptions and pharmacotherapeutic related subjects •Implemented new computer program for use of prescriptions, entries, history, medication control, stock and expiry dates etc. •Organized a complete start up of this pharmacy over a period of 2 years •Supervised a team of 10 pharmaceutical technicians processing 800 prescriptions daily •Communicated with health care providers concerning prescriptions and pharmacotherapeutic related subjects •Implemented new computer program for use of prescriptions, entries, history, medication control, stock and expiry dates etc.
-
-
Education
-
2010 - 2016
University of Guelph
Doctor of Philosophy (Ph.D.), Immunology -
2008 - 2010
University of Guelph
Master of Science (MS), Molecular and Cellular Biology -
1988 - 1994
Rijksuniversiteit Groningen
Master of Science (MS) Pharmacology, PharmD., Pharmacy -
1984 - 1988
Het Van Hall Instituut, Groningen
Bachelor of Science (BS), Livestock Management
Community
