Xuemei He

VP of Purification Technologies at GenScript
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Contact Information
us****@****om
(386) 825-5501
Location
United States, US

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Experience

    • United States
    • Biotechnology Research
    • 400 - 500 Employee
    • VP of Purification Technologies
      • 2023 - Present

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • VP of Research and Operations
      • Sep 2023 - Nov 2023

      Sanger sequencing, Nanopore sequencing (whole plasmid), DNA preps (plasmids and circular single stranded DNAs) Sanger sequencing, Nanopore sequencing (whole plasmid), DNA preps (plasmids and circular single stranded DNAs)

  • Full Circles Therapeutics
    • Albany, California, United States
    • VP of Process Development, Head of California Site Operation
      • Sep 2022 - Nov 2023

      • https://www.linkedin.com/company/full-circles-therapeutics-inc/ • Site operation • Upstream/downstream process development/QC assay development and qualification • Plasmids and circular single stranded DNA purification/production • Protein purification and production • M13 Phage particles production (Culturing and purification) • https://www.linkedin.com/company/full-circles-therapeutics-inc/ • Site operation • Upstream/downstream process development/QC assay development and qualification • Plasmids and circular single stranded DNA purification/production • Protein purification and production • M13 Phage particles production (Culturing and purification)

    • China
    • Chemical Manufacturing
    • 1 - 100 Employee
    • Deputy General Manager, Applications, Collaborations, and Development Strategy
      • Jan 2022 - Aug 2022

      • Leading the application team to develop tests guiding new product development; exploring new applications for existing products to support Marketing and Sales • Promoting collaboration with major biopharma customers in China • Providing technical leadership and consultation to company’s strategic development especially in the field of downstream purification business. • Leading the application team to develop tests guiding new product development; exploring new applications for existing products to support Marketing and Sales • Promoting collaboration with major biopharma customers in China • Providing technical leadership and consultation to company’s strategic development especially in the field of downstream purification business.

    • United States
    • Biotechnology Research
    • 700 & Above Employee
    • Chromatography media chemistry R&D manager II
      • Mar 2015 - Jan 2022

      Applications of chromatography in downstream processing: Purification of biologics (Monoclonal antibodies/fusions/fragments/ADCs, recombinant proteins/enzymes, Adenovirus and Adeno-associated virus (viral vectors) for gene therapy, virus particles/VLPs for vaccination, and long-length mRNAs) from microbial/insect/mammalian culture harvests; solubilization, purification and refolding of proteins from inclusion bodies; clearance of process and product-related impurities.; viral clearance and… Show more Applications of chromatography in downstream processing: Purification of biologics (Monoclonal antibodies/fusions/fragments/ADCs, recombinant proteins/enzymes, Adenovirus and Adeno-associated virus (viral vectors) for gene therapy, virus particles/VLPs for vaccination, and long-length mRNAs) from microbial/insect/mammalian culture harvests; solubilization, purification and refolding of proteins from inclusion bodies; clearance of process and product-related impurities.; viral clearance and safety. Offering complete solutions to clients in biologics processing, including technical consultation on impurity analysis, chemicals and hardware, and process-scale column packing Collaboration with CRO/CMO on the research and development of new product/technology. Development of chromatography media (Affinity, IEX, HIC, Mixed-mode, Ceramic Hydroxyapatite, Metal affinity, and SEC) and disposable columns for the downstream processing of biologics. Responsibilities include screening of prototypes, formulation optimization, technology transfer from R&D to production (Production procedure/QC procedure/SOP), verification and validation of product prototypes at different development phases, trouble-shooting for process & product quality as well as continuous improvement. Working with cross-functional teams of R&D, manufacturing, QA/QC, marketing, sales, and legal departments for product launching and global customer support. Process chromatography facility management (Materials, equipment acquisition and maintenance, lab safety, and waste disposal etc). R&D lab scientists management Technical training to customers and colleagues (Marketing, Sales/Field supports, Tech supports, QC, and Manufacturing) —- lectures and wet labs

    • R&D Sr. Staff Scientist
      • Mar 2012 - Feb 2015

      Development and application of polymeric process chromatography media; technical support; customer education.

    • R&D Staff Scientist
      • Mar 2006 - Feb 2012

      Development and application of polymeric chromatography media; technical support; customer education.

    • R&D Sr. Scientist
      • Mar 2003 - Feb 2006

      Development and application of affinity chromatography media; technical support; customer education.

    • R&D Scientist
      • Aug 2002 - Feb 2003

      Development and application of nucleic acid sample prep products; technical support; customer education.

    • United States
    • Higher Education
    • 1 - 100 Employee
    • Research Scientist, Lab Manager
      • Jan 2001 - Jul 2002

      Mechanistic studies of enzyme catalysis Mechanistic studies of enzyme catalysis

    • United States
    • Higher Education
    • 700 & Above Employee
    • Research Scientist
      • Jul 1997 - Dec 2000

      Mechanistic studies of enzyme catalysis Mechanistic studies of enzyme catalysis

Education

  • San Diego State University
    Advanced Certificate in Regulatory Affairs, GPA 4.0
    2007 - 2007
  • University of Minnesota-Twin Cities
    Ph.D., Biological Chemistry
    1991 - 1997
  • Zhongshan (Sun Yat-sen) University
    Bachelor of Science - BS, Chemistry
    1986 - 1990

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