Director of Lipid Analytics Research

• Apr 2022 - Present

Principal Scientist II, Mass Spectrometry Lab Head

• Aug 2012 - Apr 2022

Leading analytical efforts in support of drug discovery projects with multidisciplinary project partners to address key scientific questions by profiling relevant endogenous metabolites and lipids in oncology, neuroscience, ophthalmology, respiratory and hepatology. Liaison for the department’s AAV gene therapy initiative to characterize relevant disease biology, validate disease models, evaluate relevant PD markers, validate AAV mechanism of action. As a matrix team leader in ADC analytics, established global ADC Analytics Core Team leveraging analytics knowledge base across the organization. Conducted and managed in vivo/in vitro ADC catabolite profiling, mechanism of action studies, and ADC characterization using novel approaches in high resolution mass spectrometry (HRMS, LC/MS). Developed state of the art lipidomics platform for deep lipid profiling in relevant disease models in vivo/in vitro by high resolution LC/MS. Custom designed data pipeline in R to extract meaningful information from large data sets that are produced. Good foundation in data science using R for handling large analytical data sets allowing us to extract more information from data, design more complex experiments, profile deeper disease biology as applied in lipidomics studies.

Senior Scientist, Team Leader

• Aug 2007 - Aug 2012

Team leader of a mass spectrometry group in discovery chemistry supporting >100 medicinal chemists. Characterization and structural elucidation of impurities, reaction products and by-products using mass spectrometry and chromatography. Definitive metabolite and degradant structure elucidation by integrated LC/MS/MS/NMR. Managing open access LC/MS operation. Team leader of a mass spectrometry group in discovery chemistry supporting >100 medicinal chemists. Characterization and structural elucidation of impurities, reaction products and by-products using mass spectrometry and chromatography. Definitive metabolite and degradant structure elucidation by integrated LC/MS/MS/NMR. Managing open access LC/MS operation.

Senior Research Scientist, Project Manager

• Mar 2004 - Aug 2007

Method development, validation and troubleshooting of LC/MS/MS bioanalytical assays in support of GLP, non-GLP analysis of pharmaceuticals in biological matrices. Investigation of novel strategies for minimizing MS matrix effects for more reliable and sensitive bioanalytical methods. Method development, validation and troubleshooting of LC/MS/MS bioanalytical assays in support of GLP, non-GLP analysis of pharmaceuticals in biological matrices. Investigation of novel strategies for minimizing MS matrix effects for more reliable and sensitive bioanalytical methods.

Research Chemist

• Jul 2000 - Mar 2004

Development and validation of GLP-compliant methods for analytical support of toxicological studies. Serving as an analytical study director for tox. projects. Determination and characterization of compounds in biological matrices (small molecules, metabolites, complex formulation mixtures). Development and validation of GLP-compliant methods for analytical support of toxicological studies. Serving as an analytical study director for tox. projects. Determination and characterization of compounds in biological matrices (small molecules, metabolites, complex formulation mixtures).

Mass Spectrometry Specialist

• 1997 - 2000

Managing core mass spectrometry facility serving customers from academic, industry, and medical institutions in NE Ohio. Managing core mass spectrometry facility serving customers from academic, industry, and medical institutions in NE Ohio.