Formulation Scientist

• Oct 2021 - Present

Research Associate

• Sep 2015 - Sep 2021

 Prepared stable nanosuspensions using wet stirred media milling, anti-solvent precipitation, and homogenization approaches.  Developed amorphous solid dispersions (ASDs) and dried nanosuspension using hot melt extrusion (HME) and spray drying (SD) techniques to enhance drug solubility/dissolution rate including the downstream processing of final powdered blends and tablets.  Studied effects of type and concentrations of surfactant and lipids on stability of nano lipid drug… Show more  Prepared stable nanosuspensions using wet stirred media milling, anti-solvent precipitation, and homogenization approaches.  Developed amorphous solid dispersions (ASDs) and dried nanosuspension using hot melt extrusion (HME) and spray drying (SD) techniques to enhance drug solubility/dissolution rate including the downstream processing of final powdered blends and tablets.  Studied effects of type and concentrations of surfactant and lipids on stability of nano lipid drug carriers.  Worked with Natoli Engineering on troubleshooting existing manufacturing process as well as development of solid oral dosage forms.  Worked with new chemical entities (NCEs) on several NDA projects to optimize dry and wet granulation process using roller compaction, high shear granulator, and fluidized bed granulator.  Worked on multi-unit particulate systems (MUPS) using FBD. Investigated efficiency of enteric coating on tablets using dissolution studies.  Investigated tablet processing problems such as sticking, picking, capping etc. for various internal and external collaborators using Piccola 8-station rotary tablet press and presster™ compaction simulator.  Performed sample analysis/ material’s solid state and drug product characterization/ supported product development activities for pharmaceutical companies, contract research and manufacturing organizations (CRO’s & CMO’s). Worked on projects and other activities conducted under good manufacturing practices (GMP’s). Product Development Skills: Preformulation, compaction profile (tabletability, compressibility, and compactability), drug-excipient compatibility and blend uniformity studies, rheological behavior of powders and fluids, relative crystallinity, particle morphology, and solubility studies. Analytical & characterization techniques: mDSC, TGA, moisture sorption, PXRD, FTIR, microscopy, Malvern 3000, Zetasizer, UV, HPLC, UPLC, disintegration test, In-vitro drug release studies (dissolution and diffusion). Show less  Prepared stable nanosuspensions using wet stirred media milling, anti-solvent precipitation, and homogenization approaches.  Developed amorphous solid dispersions (ASDs) and dried nanosuspension using hot melt extrusion (HME) and spray drying (SD) techniques to enhance drug solubility/dissolution rate including the downstream processing of final powdered blends and tablets.  Studied effects of type and concentrations of surfactant and lipids on stability of nano lipid drug… Show more  Prepared stable nanosuspensions using wet stirred media milling, anti-solvent precipitation, and homogenization approaches.  Developed amorphous solid dispersions (ASDs) and dried nanosuspension using hot melt extrusion (HME) and spray drying (SD) techniques to enhance drug solubility/dissolution rate including the downstream processing of final powdered blends and tablets.  Studied effects of type and concentrations of surfactant and lipids on stability of nano lipid drug carriers.  Worked with Natoli Engineering on troubleshooting existing manufacturing process as well as development of solid oral dosage forms.  Worked with new chemical entities (NCEs) on several NDA projects to optimize dry and wet granulation process using roller compaction, high shear granulator, and fluidized bed granulator.  Worked on multi-unit particulate systems (MUPS) using FBD. Investigated efficiency of enteric coating on tablets using dissolution studies.  Investigated tablet processing problems such as sticking, picking, capping etc. for various internal and external collaborators using Piccola 8-station rotary tablet press and presster™ compaction simulator.  Performed sample analysis/ material’s solid state and drug product characterization/ supported product development activities for pharmaceutical companies, contract research and manufacturing organizations (CRO’s & CMO’s). Worked on projects and other activities conducted under good manufacturing practices (GMP’s). Product Development Skills: Preformulation, compaction profile (tabletability, compressibility, and compactability), drug-excipient compatibility and blend uniformity studies, rheological behavior of powders and fluids, relative crystallinity, particle morphology, and solubility studies. Analytical & characterization techniques: mDSC, TGA, moisture sorption, PXRD, FTIR, microscopy, Malvern 3000, Zetasizer, UV, HPLC, UPLC, disintegration test, In-vitro drug release studies (dissolution and diffusion). Show less

Merck AH Formulation Development Intern

• Jun 2020 - Aug 2020

 Developed high-throughput excipient compatibility test protocol for Chew Tablets and Tablets.  Assisted in analyzing the data from design of experiments utilized to optimized wet granulation process.  Researched, compiled, and presented a draft guidance document for fit-for-purpose prototype injectable/parenteral formulations development protocol.  Developed high-throughput excipient compatibility test protocol for Chew Tablets and Tablets.  Assisted in analyzing the data from design of experiments utilized to optimized wet granulation process.  Researched, compiled, and presented a draft guidance document for fit-for-purpose prototype injectable/parenteral formulations development protocol.

MRL Pharm Sci-Analytical Science Intern

• Jun 2018 - Aug 2018

 Distinguished kinetic solubilities of a salt and free base form using a surface dissolution UV imaging system.  Studied the relationship between intrinsic dissolution rate and salt disproportionation risk at all pH conditions  Developed a novel method to characterize the drug release lag time from film-coated tablets using SDi2.  Distinguished kinetic solubilities of a salt and free base form using a surface dissolution UV imaging system.  Studied the relationship between intrinsic dissolution rate and salt disproportionation risk at all pH conditions  Developed a novel method to characterize the drug release lag time from film-coated tablets using SDi2.

R&D Intern (Co-op) - Product Development

• Sep 2016 - Dec 2016

• Individual project handling and completing the product profile by identification (q1), Analyzing (q2) & giving inputs to develop identical microstructure (q3) as an Intern with continuing ongoing academic courses at Long Island University. • Developing the rheological methods of complex sterile ophthalmic product to formulate the identical microstructure to the brand. Also, performing different viscosity and gel-sol based product studies such as Shear Rate, Non-Newtonian… Show more • Individual project handling and completing the product profile by identification (q1), Analyzing (q2) & giving inputs to develop identical microstructure (q3) as an Intern with continuing ongoing academic courses at Long Island University. • Developing the rheological methods of complex sterile ophthalmic product to formulate the identical microstructure to the brand. Also, performing different viscosity and gel-sol based product studies such as Shear Rate, Non-Newtonian fluidics. • De-formulation of the sterile products by developing the formulation based on the computational model inter-linking the Osmolality, Buffer Capacity, pH & elemental analysis. • Assisting in the quantification of the ingredients using HPLC by developing the method/Standard method such as Extraction/Derivatization & learnt to identify the different Polymer grade, polymorph & particle/globule size distribution

R&D Intern - Product Development

• Jun 2016 - Aug 2016

• Understand the principal areas of preformulation and its associated studies and help in providing inputs to Develop the portfolio of information and Design Dosage form Development. • Support the formulation activities in preparation of bench scale product development batches and learning to develop the various analytical techniques to derive the results and effectively changing its parameters to develop the required product. • Learn and Perform Reverse engineering and characterization… Show more • Understand the principal areas of preformulation and its associated studies and help in providing inputs to Develop the portfolio of information and Design Dosage form Development. • Support the formulation activities in preparation of bench scale product development batches and learning to develop the various analytical techniques to derive the results and effectively changing its parameters to develop the required product. • Learn and Perform Reverse engineering and characterization of ophthalmic Products. • cGMP, GLP, GDP Formulations: Sterile Ophthalmic: Microemulsions, Ointments, Creams, suspensions, Gel Forming Solutions, IKA. Characterization: HPLC, mDSC, Hot Stage/PLM, GC, IPQC, Rheological Studies & Osmometer.

Product Specialist

• Mar 2014 - May 2015

• Performed pre-formulation and formulation studies for the product development of solid dosage forms. • Conducted compatibility studies of the active compounds and excipients. • Performed pre-formulation and formulation studies for the product development of solid dosage forms. • Conducted compatibility studies of the active compounds and excipients.

Business Development Executive

• Jan 2013 - Mar 2014

Marketed by Scientific detailing about Pharmaceutical/Neutraceutical Products/ Stem Cell Services & established the business through the walk-in-visits to the Registered Medical Practitioners & other agencies as well. Also, Made effective presentations to the RMP’s, prospects & clients to promulgate the concept & the products for the betterment of respective associate. Introduced the most promising regenerative medicine of Stem cells to Gynecologist & Various other Physicians. Marketed by Scientific detailing about Pharmaceutical/Neutraceutical Products/ Stem Cell Services & established the business through the walk-in-visits to the Registered Medical Practitioners & other agencies as well. Also, Made effective presentations to the RMP’s, prospects & clients to promulgate the concept & the products for the betterment of respective associate. Introduced the most promising regenerative medicine of Stem cells to Gynecologist & Various other Physicians.

Trainee

• Jul 2012 - Dec 2012

Performed pre-formulation studies for the nanosuspensions like Zeta Potential, Particle Size Analysis (DLS), Partition studies, Polarized light microscope etc Performed pre-formulation studies for the nanosuspensions like Zeta Potential, Particle Size Analysis (DLS), Partition studies, Polarized light microscope etc

Industrial Trainee

• May 2011 - Jun 2011

Analyzed samples obtained from primary production using SOPs to demonstrate compliance with relevant specifications. Analyzed samples obtained from primary production using SOPs to demonstrate compliance with relevant specifications.