Experience

Spectralys Biotech

• Biotechnology
• 1 - 100 Employee

• Scientist

  • Jan 2019 - Present

  Spectralys Biotech (www.spectralysbiotech.com) offers innovative analytical solutions for therapeutic proteins based on infrared spectroscopy (FTIR). Based on 10+ year expertise of the SFMB lab of the Université Libre de Bruxelles in infrared spectroscopy, our team has developed a superior knowhow in spectral measurement and interpretation, allowing our experts to simultaneously assess structural integrity of therapeutic proteins and to quantify its key components and excipients (patent filed). Depending on specific situations, gathering these data would require leveraging 3 to 4 distinct techniques and protocols today. Moreover, infrared spectroscopy allows to analyse protein structure and components in a precise, quick and direct manner, with limited sample volume and without need for extensive sample pre-treatment or recurring calibration. Thanks to these attributes, speed of measurement can be up to 3 to 10 times higher than other techniques. Given those strengths, our expertise is particularly relevant to study the stability of therapeutic proteins, to verify batch-to-batch consistency or to compare and optimize various production parameters. Should you be interested in a demonstration of our capabilities, please do not hesitate Show less



Expleo Lifesciences & Healthcare (Formerly Assystem Care)

• France
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Consultant

  • Jun 2015 - Dec 2018

  Experiences in Companies :- LFB (FR)- YposKesi (FR)- GlaxoSmithKline (BE)- Généthon (FR)- Stallergenes Greer (FR)May 2018 - December 2018Context and mission: Production Department - Blood products facilityRoles and responsibilities: Task Force Remediation Project - Deviation Backlog• Deviation management (root-cause analysis, Impact assessment, CAPA proposition) mostlyrelated to filling, lyophilizing, capping, and metrology.• Follow-up and update of relevant KPIs (opening, closure, backlog)December 2016 - Janvier 2018Context and mission: Quality Control Laboratory - Gene therapy treatments.Roles and responsibilities: Analytical method validation (qPCR, ELISA, ...)• Perform laboratory activities related to method validation (planning, reagents, ...)• Set up design of experiments.• Prepare the necessary documentation on procedures, protocols and reports.• Analysis of data and verification of results Show less

• Consultant

  • Jun 2015 - Dec 2018

  Experiences in Companies :- LFB (FR)- YposKesi (FR)- GlaxoSmithKline (BE)- Généthon (FR)- Stallergenes Greer (FR)May 2016 - October 2016Context and mission: R&D - Clinical Studies - Samples Management and TestingRoles and responsibilities: Task Force Remediation Project : Deviation and CAPA Backlog• Project preparation (planning, visual management dashboard and KPI, strategy) and follow-up (daily and weekly, KPI, steering committee).• CAPA backlog rationalization and tracking for closure.• Coaching on root cause analysis, design and propose templates and tools.• Propose specific way of working to facilitate deviation and CAPA management.January 2016 - May 2016Context and mission: Quality Control Laboratory - Gene therapy treatments.Roles and responsibilities: In charge of the management of reagents:• Gap analysis of the actual reagents flow, from the reception until use in the laboratory.• Use of a risk management methodology to calculate the shelf life reduction factor for determination of the expiry date after opening.• Documents writing (SOPs, Forms, Excel databases) to manage reagents (reception, labeling, quarantine storage, etc.)June 2015 - December 2015Context and mission: Quality Control Laboratory - Allergen Immunotherapy treatmentsPart of a multidisciplinary team (validation, production, QC, engineering) in charge of implementing an important process validation planRoles and responsibilities: Change control management to implement new analytical methods in QC laboratory (Immunology, Chemistry and Microbiology platform):• Review QC data for validation protocols and reports.• Act as a “facilitator” between different departments (QA, QC, AD & RA) to speed up the change control process. Show less



Puratos

• Belgium
• Food and Beverage Manufacturing
• 700 & Above Employee

• Research Laboratory Technician

  • Oct 2014 - Dec 2014

  See below See below



Puratos

• Belgium
• Food and Beverage Manufacturing
• 700 & Above Employee

• Research Laboratory Technician

  • Feb 2014 - May 2014

  Context and mission: • Development of sourdoughs showing a “natural" antifungal activity for the purpose of decreasing the use of calcium propanoate additive (E282). • Development of a QC test to assess the antifungal activity of sourdoughs produced. Roles and responsibilities: Research Laboratory Technician • R&D production of sourdoughs in erlen, bioreactor and patolevain. • Analytical analysis: microbiological, viscosity, quantitative HPLC, pH/acidity and results analysis. • Petri dish QC test development: media composition, incubation time, microbial strains concentration, etc. • Protocol writing and testing, Report writing Show less



Laboratory of Chemistry & Biology of Membranes and Nanoobjets (CBMN)

• Région de Bordeaux, France

• Research Engineer

  • Jan 2012 - Feb 2013

  Context and mission: • Development of solutions in Matlab for processing spectral data from FTIR images (Infrared spectroscopy Fourier transform) • Attempts to culture cells directly on an ATR crystal for FTIR acquisitions in vitro • Creation of a database with FTIR images of different types of brain tumors implanted in mices Roles and responsibilities: Research Engineer • Gather relevant information from bibliographic resources • Determine parameters acquisition and acquire FTIR images of tissues and collagen to construct a FTIR images database • Determine parameters acquisition and attempt to acquire FTIR images of cells in culture • Develop a data-treatment based on a curve fitting module to add in an existing homemade Matlab program and apply it to the database • Apply different statistical analyses (Student's t-Tests, PCA, HCA) • Protocol writing and testing, Report writing • Keeping a laboratory Book following GLP guidelines. • Analyze, comment, discuss and present research results during team meetings Show less