Vien Le
Research Scientist at Inception Therapeutics- Claim this Profile
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Bio
Experience
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Inception Therapeutics
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United States
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Biotechnology Research
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1 - 100 Employee
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Research Scientist
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May 2021 - Present
San Diego, California, United States
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Research Scientist
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Nov 2020 - May 2021
San Diego, California, United States
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City of Hope
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United States
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Hospitals and Health Care
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700 & Above Employee
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Postdoctoral Researcher
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Oct 2016 - Nov 2020
Duarte, California, United States - Developed and executed experiments involving prostate cancer and prostate development by using novel and cutting-edge approaches. - By using Genetically Engineered Mouse Model (GEMM) we answered the questions about mechanisms of P10 and E-cadherin in the prostate cancer initiation and progression. - In another GEMM, we filled the gap of the knowledge about the decisive role of androgen receptor in mesenchymal cells, in particularly in Gli1-expressing cells, in prostate initiation… Show more - Developed and executed experiments involving prostate cancer and prostate development by using novel and cutting-edge approaches. - By using Genetically Engineered Mouse Model (GEMM) we answered the questions about mechanisms of P10 and E-cadherin in the prostate cancer initiation and progression. - In another GEMM, we filled the gap of the knowledge about the decisive role of androgen receptor in mesenchymal cells, in particularly in Gli1-expressing cells, in prostate initiation, development, regeneration and cancer. - Optimized and troubleshooted up-to-date techniques including preparing samples for single cell sequencing and ChIP-seq with low cell number, to determine the crucial functions and correlation of androgen receptor and Sonic hedgehog signaling pathways in androgen-induced prostate cell fate and growth. - Hands on experiments such as xenograft, 3D organoid culture, and tissue culture (ex-vivo) to assess the effects of pharmaceutical materials on prostate development. Show less
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University of California, San Francisco
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United States
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Higher Education
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700 & Above Employee
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Postdoctoral Researcher
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Feb 2013 - Feb 2016
San Francisco General Hospital - Work with multiple rabbit models to identify the pathogenesis of Staphylococcus aureus in various infections, including skin and skin structure, pneumonia, endocarditis and joint knee infections. - Collaborate with companies to assess the novel antibodies and/or antibiotics (tedizolid) for treatment of Staphylococcus aureus infections in different in-vivo models. - Keep up-to-date knowledge and apply to current research which generate live-attenuated Staphylococcus aureus vaccine base… Show more - Work with multiple rabbit models to identify the pathogenesis of Staphylococcus aureus in various infections, including skin and skin structure, pneumonia, endocarditis and joint knee infections. - Collaborate with companies to assess the novel antibodies and/or antibiotics (tedizolid) for treatment of Staphylococcus aureus infections in different in-vivo models. - Keep up-to-date knowledge and apply to current research which generate live-attenuated Staphylococcus aureus vaccine base on the updated knowledge using the knock-out methods. Show less
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Oxford University Clinical Research Unit
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Vietnam
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Research Services
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200 - 300 Employee
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Associate Researcher
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Sep 2004 - May 2008
Ho Chi Minh City, Vietnam - Expertise in microbiology knowledge and techniques. - Determine the prevalence of Streptococcus pneumoniae serotypes from young school children to prepare for the vaccine project using molecular assay not excluded to MLST and sequencing analysis.
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Education
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Oxford University
Doctor of Philosophy (PhD), Clinical Medicine