Vengadeshprabhu Karuppagounder
Scientist II at Juvena Therapeutics- Claim this Profile
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Tamil Native or bilingual proficiency
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English Full professional proficiency
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Bio
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Experience
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Juvena Therapeutics
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United States
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Biotechnology Research
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1 - 100 Employee
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Scientist II
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Mar 2023 - Present
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Penn State College of Medicine
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United States
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Higher Education
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700 & Above Employee
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Postdoctoral Researcher
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Dec 2017 - Feb 2023
• Novel findings present elevated GRK2 signaling in chondrocytes as a driver of cartilage degradation and paroxetine as a disease-modifying drug for synovitis and Osteoarthritis treatment • Established new methods to study the role of GRK2 signaling in macrophage/immune cells in aging mouse models. • Achieved First author in leading scientific journals, Science Translational Medicine, & International Journal of Molecular Sciences. As a co-author, I have published several research articles. • Exhibited excellent working skills ranging from developing comprehensive project plans, formulating hypotheses, result-oriented experimentation, data interpretation and analysis. Show less
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Research Associate
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Dec 2012 - Mar 2017
• Our novel findings discovered small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats • We identified the HMGB1 signaling drive an important role in skin inflammation, and quercetin/resveratrol treatments could be a promising agent for atopic dermatitis. • Also, independently investigated the cancer drug induced nephrotoxicity and cardiotoxicity in animal models and treatment options. • Gained in-depth research experience in the field of pharmacology, immunology, and molecular biology, transgenic animal model and fluorescent/confocal imaging techniques. Show less
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K.M.C.H. COLLEGE OF PHARMACY (Inst. Code - 114), COIMBATORE
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India
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Higher Education
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1 - 100 Employee
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Lecturer
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Sep 2010 - Oct 2012
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Torrent Pharma Inc.
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United States
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Pharmaceutical Manufacturing
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700 & Above Employee
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Medical Representative
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Sep 2007 - May 2008
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Education
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Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Doctor of Philosophy (Ph.D.), Pharmacology -
K.M.C.H. COLLEGE OF PHARMACY (Inst. Code - 114), COIMBATORE
Master’s Degree, Pharmaceutical Sciences -
K.M.C.H. COLLEGE OF PHARMACY (Inst. Code - 114), COIMBATORE
Bachelor’s Degree, Pharmaceutical Sciences