Experience

Chugai Pharmabody Research

• Singapore
• Biotechnology
• 1 - 100 Employee

• Senior Scientist

  • Mar 2020 - Present

  Middle Molecule Unit + Project Leader for Drug Discovery research (Lead identification) + Cyclic peptide technology + High throughput screening using display library + Nucleic acids research Middle Molecule Unit + Project Leader for Drug Discovery research (Lead identification) + Cyclic peptide technology + High throughput screening using display library + Nucleic acids research



Nanyang Technological University, Singapore

• Singapore
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Fellow

  • Oct 2015 - Mar 2020

  Department of Physics and Applied Physics, NTU, SingaporeAnalytical and problem solving skills• Designed and investigated novel nuclease-resistant antisense oligonucleotides for improved cellular delivery and gene silencing in mammalian cells (provisional patent filed: PCT/SG2017/050231)• Designed and initiated in vivo study of antisense oligonucleotides• Introduced new methodology and instrumentation for antisense oligonucleotide production to cater for drug screenings on cell cultures and animals, improving work efficiency 5-fold• Successfully implemented SOPs for routine handling of cell cultures, RNA isolation, and analysis via RT-qPCR and western blot • Implemented database logging for internal data review and report generation for external collaborators Writing and communication skills• Presented milestones to internal and international collaborators• Presented technical reports and published papers in leading journals and conferences• Planned and prepared proposals and budgets for successful grant and patent applications Project Management• Coordinated research between chemists and biologist in the antisense therapeutics team to drive optimization of antisense oligonucleotide• Successfully liaised with vendors to procure instruments worth over $500,000• Worked closely with both academic groups and CROs to coordinate animal experiment Supervision• Co-lead in antisense therapeutics project, supervising over 20 junior and senior researchers on biochemistry and biology research projects • Recruited, trained and supervised 5 research staffs to support DNA chemistry, peptide chemistry and RNA biology research in the antisense therapeutics project Show less

• Postgraduate Researcher

  • Aug 2010 - Sep 2015

  Department of Physics and Applied Physics, NTU, Singapore• Elucidated the high-resolution G-quadruplex structure of a human telomeric sequences which incorporates the effects of DNA damage (featured on Nucleic Acids Research cover page)• Successfully identified a patented, minimal parallel G-quadruplex binding peptide fragment and resolved its high-resolution solution structure using NMR spectroscopy (US Patent 9,815,868) • Successfully cloned, expressed and purified 11 recombinant proteins for NMR spectroscopy and enzymatic assays• Investigated binding affinities of DNA-binding proteins with different DNA structures using gel shift assay and NMR titration Show less



Nanyang Technological University

• Singapore
• Higher Education
• 700 & Above Employee

• Undergraduate Researcher

  • May 2007 - May 2010

  Department of Chemistry and Biological Chemistry, NTU, Singapore • Successfully co-developed a patented fabrication method of gold/silver nanoparticles using protein nanocages for controlled sizing in gold/silver nanoparticles production (US Patent 9,925,592) • Engineered proteins to probe protein-protein interactions controlling protein nanocages assembly Department of Chemistry and Biological Chemistry, NTU, Singapore • Successfully co-developed a patented fabrication method of gold/silver nanoparticles using protein nanocages for controlled sizing in gold/silver nanoparticles production (US Patent 9,925,592) • Engineered proteins to probe protein-protein interactions controlling protein nanocages assembly



University of Southampton

• United Kingdom
• Higher Education
• 700 & Above Employee

• Visiting Researcher

  • Jul 2009 - Dec 2009

  Department of Chemistry, University of Southampton, UK • Successfully developed a method for quick and efficient ligand-free ligation of 3 different oligonucleotides into one strand, with the results published in a peer-reviewed journal • Synthesized a novel diene oligonucleotide modifier for Diels-Alder ligation Department of Chemistry, University of Southampton, UK • Successfully developed a method for quick and efficient ligand-free ligation of 3 different oligonucleotides into one strand, with the results published in a peer-reviewed journal • Synthesized a novel diene oligonucleotide modifier for Diels-Alder ligation