Experience

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)

• Italy
• Research Services
• 100 - 200 Employee

• Project Leader in Gene and Cell Therapy

  • Jun 2019 - Present

  Milan, Lombardy, Italy



Ospedale San Raffaele

• Italy
• Hospitals and Health Care
• 700 & Above Employee

• Project Leader in Gene and Cell therapy - Marie Skłodowska-Curie (MSCA) Fellow

  • Jul 2019 - Present

  Milan Area, Italy Research projects in the field of neuroscience - gene and cell therapy - CRISPR/Cas9-based in vivo / ex vivo gene therapy for the treatment of neurodegenerative disorders - Development of hiPSC-derived neural stem cell-based therapy for the treatment of leukodystrophies and neurodegenerative disorders - Development of 3D organoids for disease modeling in lysosomal storage disorders Unit of gene / neural stem cell therapy for lysosomal storage diseases (Dr… Show more Research projects in the field of neuroscience - gene and cell therapy - CRISPR/Cas9-based in vivo / ex vivo gene therapy for the treatment of neurodegenerative disorders - Development of hiPSC-derived neural stem cell-based therapy for the treatment of leukodystrophies and neurodegenerative disorders - Development of 3D organoids for disease modeling in lysosomal storage disorders Unit of gene / neural stem cell therapy for lysosomal storage diseases (Dr. Angela Gritti) - Telethon Institute for Gene Therapy (Prof. Luigi Naldini) Show less



Imagine Institute of Genetic Diseases

• France
• Research Services
• 200 - 300 Employee

• Research fellow in Gene and Cell Therapies (Hematology and Neuroscience)

  • Sep 2014 - May 2019

  Paris, France Research projects in the field of hematology: - CRISPR/Cas9-based ex vivo gene therapy to re-activate fetal hemoglobin for the treatment of Sickle Cell Disease; - Generation of lentiviral vectors combining gene-addition and genome-editing approaches for the treatment of Sickle Cell Disease (awarded and founded by National Transfer Technology Office SATT IDF Innov). Research projects in the field of neuroscience/cell therapy: - Genome-wide definition of regulatory regions and… Show more Research projects in the field of hematology: - CRISPR/Cas9-based ex vivo gene therapy to re-activate fetal hemoglobin for the treatment of Sickle Cell Disease; - Generation of lentiviral vectors combining gene-addition and genome-editing approaches for the treatment of Sickle Cell Disease (awarded and founded by National Transfer Technology Office SATT IDF Innov). Research projects in the field of neuroscience/cell therapy: - Genome-wide definition of regulatory regions and transcripts during hiPSC neural commitment in physiological and pathological conditions to verify the safety and efficacy of hiPSC-derived NSC-based cell therapy and to define potential pharmacological targets for the treatment of leukodystrophies. Laboratory of chromatin and gene regulation during development (Dr. Annarita Miccio) - INSERM UNIT U1163 (Prof. Marina Cavazzana, Prof. Alain Fischer) Show less



San Raffaele Biomedical Science Park

• Hospitals and Health Care
• 1 - 100 Employee

• Post-Doc fellow in Gene and Cell Therapies

  • Jun 2011 - Aug 2014

  Research focused on cell replacement and gene transfer strategies for leukodystrophies: - Evaluation of safety and efficacy of intracerebral administration of Lentiviral Vectors in juvenile non-human primates - Modeling leukodystrophies by using patient-specific induced pulripoten stem cells (iPSCs) - Evaluation of safety and efficacy of intrathecal transplantation of gene-corrected patient-specific iPSC-derived neural progenitors in MLD and GLD mouse models Division… Show more Research focused on cell replacement and gene transfer strategies for leukodystrophies: - Evaluation of safety and efficacy of intracerebral administration of Lentiviral Vectors in juvenile non-human primates - Modeling leukodystrophies by using patient-specific induced pulripoten stem cells (iPSCs) - Evaluation of safety and efficacy of intrathecal transplantation of gene-corrected patient-specific iPSC-derived neural progenitors in MLD and GLD mouse models Division of Regenerative Medicine, Stem Cells and Gene Therapy (Dr. Angela Gritti and Prof. Luigi Naldini) Show less



University of Piemonte Orientale

• Italy
• Biotechnology Research
• 1 - 100 Employee

• Post-doc fellow in Pharmacology

  • Feb 2010 - May 2011

  Research focused on the pharmacological modulation of adult neurogenesis: - evaluation of Tapentadol-mediated effects on adult hippocampal neurogenesis (project supported by Grünenthal GmbH) - evaluation of Alpha2-delta ligands effects in the modulation of adult hippocampal neurogenesis and in the prevention of depressive like behaviour induced by chronic restraint stress Neuroplasticity and Neuropathic pain laboratory (Prof. Mariagrazia Grilli and Prof. Pier Luigi… Show more Research focused on the pharmacological modulation of adult neurogenesis: - evaluation of Tapentadol-mediated effects on adult hippocampal neurogenesis (project supported by Grünenthal GmbH) - evaluation of Alpha2-delta ligands effects in the modulation of adult hippocampal neurogenesis and in the prevention of depressive like behaviour induced by chronic restraint stress Neuroplasticity and Neuropathic pain laboratory (Prof. Mariagrazia Grilli and Prof. Pier Luigi Canonico)

• PhD student in Pharmacology

  • Nov 2006 - Jan 2010

  Research focused on the role of RAGE/NF-kB axis in adult SVZ and hippocampal neurogenesis: relevance for Alzheimer's disease Neuroplasticity and Neuropathic pain laboratory (Prof. Mariagrazia Grilli and Prof. Pier Luigi Canonico)



Centre Paul Broca-INSERM, Paris, France

• Undergraduated student in Neuroscience

  • Nov 2004 - Dec 2005

  Paris Area, France Research focused on transgenic Caenorhabditis Elegans strains expressing murine Engrailed-1 protein as a model for high-throughput screening of drugs against neurodegenerative diseases: relevance for Parkinson's disease Laboratory of Dr. Christian Nèri



ITB-CNR

• Undergraduate Student in genetic diseases

  • Mar 2002 - Jun 2003

  Milan Area, Italy Research focused on the congenital disorder Ulnary-Mammary Syndrome (UMS): individuation of novel TBX3 mutations and investigation of TBX3 functions in the development of mammary ephitelial cells Dulbecco Telethon Institute laboratory (Dr. Giorgio Merlo)