Umamaheswaran Gurusamy
Postdoctoral at University of California, San Francisco - School of Medicine- Claim this Profile
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English Verhandlungssicher
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Tamil Muttersprache oder zweisprachig
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Bio
Kamal Prashad Segar M.Tech, Ph.D „I had the opportunity to work with Uma at the prestigious JIPMER campus. As a geneticist by training, Uma is passionate about exploring new trends & technologies and utilize them to understand oncology & metabolic disorders. He is a team player and has exceptional leadership skills. I wish him good luck in all his future endeavours.
Lakshmi Shree Mahadevan „I am fortunate to have worked with Dr. Gurusamy for 3 years during my medical school at JIPMER. He was a senior research associate at that time, and he introduced me to molecular biology and basic science research. We worked on polymorphisms of aromatase gene that causes differences in aromatase inhibitor drug metabolism. He is extremely passionate about science, methodical, meticulous, and resourceful. I was impressed by his level of conceptual understanding and his explanations are so clear and simple that even a beginner can follow with ease. He is an inspiring mentor whom I will always look up to and continue to learn from.
Kamal Prashad Segar M.Tech, Ph.D „I had the opportunity to work with Uma at the prestigious JIPMER campus. As a geneticist by training, Uma is passionate about exploring new trends & technologies and utilize them to understand oncology & metabolic disorders. He is a team player and has exceptional leadership skills. I wish him good luck in all his future endeavours.
Lakshmi Shree Mahadevan „I am fortunate to have worked with Dr. Gurusamy for 3 years during my medical school at JIPMER. He was a senior research associate at that time, and he introduced me to molecular biology and basic science research. We worked on polymorphisms of aromatase gene that causes differences in aromatase inhibitor drug metabolism. He is extremely passionate about science, methodical, meticulous, and resourceful. I was impressed by his level of conceptual understanding and his explanations are so clear and simple that even a beginner can follow with ease. He is an inspiring mentor whom I will always look up to and continue to learn from.
Kamal Prashad Segar M.Tech, Ph.D „I had the opportunity to work with Uma at the prestigious JIPMER campus. As a geneticist by training, Uma is passionate about exploring new trends & technologies and utilize them to understand oncology & metabolic disorders. He is a team player and has exceptional leadership skills. I wish him good luck in all his future endeavours.
Lakshmi Shree Mahadevan „I am fortunate to have worked with Dr. Gurusamy for 3 years during my medical school at JIPMER. He was a senior research associate at that time, and he introduced me to molecular biology and basic science research. We worked on polymorphisms of aromatase gene that causes differences in aromatase inhibitor drug metabolism. He is extremely passionate about science, methodical, meticulous, and resourceful. I was impressed by his level of conceptual understanding and his explanations are so clear and simple that even a beginner can follow with ease. He is an inspiring mentor whom I will always look up to and continue to learn from.
Kamal Prashad Segar M.Tech, Ph.D „I had the opportunity to work with Uma at the prestigious JIPMER campus. As a geneticist by training, Uma is passionate about exploring new trends & technologies and utilize them to understand oncology & metabolic disorders. He is a team player and has exceptional leadership skills. I wish him good luck in all his future endeavours.
Lakshmi Shree Mahadevan „I am fortunate to have worked with Dr. Gurusamy for 3 years during my medical school at JIPMER. He was a senior research associate at that time, and he introduced me to molecular biology and basic science research. We worked on polymorphisms of aromatase gene that causes differences in aromatase inhibitor drug metabolism. He is extremely passionate about science, methodical, meticulous, and resourceful. I was impressed by his level of conceptual understanding and his explanations are so clear and simple that even a beginner can follow with ease. He is an inspiring mentor whom I will always look up to and continue to learn from.
Experience
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University of California, San Francisco - School of Medicine
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United States
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Higher Education
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100 - 200 Employee
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Postdoctoral
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Mai 2019 - –Heute
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Frontiers
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Switzerland
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Research Services
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700 & Above Employee
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Review Editor for Frontiers in Endocrinology
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Mai 2021 - –Heute
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Review Editor for Frontiers in Genetics
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Jan. 2021 - –Heute
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Review Editor for Frontiers in Pharmacology
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Juli 2020 - –Heute
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Review Editor for Frontiers in Oncology
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Juli 2020 - –Heute
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Linköping University
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Sweden
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Higher Education
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700 & Above Employee
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Postdoctoral Research Fellow
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Dez. 2017 - März 2019
To identify the genomic changes (SNV, Indels, CNV, DNA methylation, DEG) and the corresponding signaling pathways behind differential response to radiation sensitivity in patients with rectal cancer from Swedish clinical trial cohort by applying high-throughput WES, WGBS, and RNA sequencing methodology. Also to test whether APR-246 synergize with gamma irradiation to inhibit the tumor cell growth in cultured cells as well as patient derived xenograft models of colorectal cancer. Additionally, to identify the arsenal of genes and pathways involved in synergism and to explore the possible molecular mechanisms associated with this process by applying RNA-seq and CRISPR/Cas9 gene editing methodology.
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Jawaharlal Institute Of Postgraduate Medical Education And Research (JIPMER)
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India
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Hospitals and Health Care
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700 & Above Employee
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Graduate Research Assistant
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Jan. 2012 - Sept. 2017
Letrozole is commonly administered in postmenopausal patients to treat endocrine-responsive breast cancer. Although it is an effective anticancer drug, pronounced inter-patient difference exists in drug responsiveness and adverse events. My Ph.D. research focused on ascertaining the relationship between gene polymorphisms and treatment outcomes of adjuvant letrozole, using genomics, clinical pharmacology, and bioinformatics analysis. Our clinical findings revealed that the occurrence of adverse events and breast cancer relapse, and unfavorable event-free survival of HR+ breast cancer patients on adjuvant letrozole therapy are related to the genetic variations in the CYP19A1 gene.
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Senior Research Fellow
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Jan. 2008 - Dez. 2015
Genetic differences among patients are believed to account for variations in drug response and toxicity. Pharmacogenomics uses a patient's genetic information to predict individual responses to medication. I worked on evaluating the genetic underpinnings of these phenomena for the following drugs: Tamoxifen (CYP2D6 and CYP2C19), Clopidogrel (MDR1, CYP3A5, and P2Y12), Metformin (OCT1), Glibenclamide (MDR1), Anthracycline (MDR1), Morphine (ABCB1), and Salbutamol (ADBR2), etc., Further, the information regarding the frequency distribution of the defective alleles of genes concerned with ADME within a particular population is essential in adapting pharmacogenomics. Therefore, I have also established the allele and genotype frequency distribution of variants of genes (ABCB1, CYP3A5, CYP2A6, CYP2C8, CYP2J2, CYP2E1, SLC22A1, TPMT, and UGT1A1) encoding drug-metabolizing, drug transporter, and drug target proteins and assessed their inter-intra ethnic differences.
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Junior Research Fellow
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Jan. 2007 - Dez. 2007
Cardiovascular diseases such as essential hypertension, myocardial infarction, and stroke are complex multi-factorial disorders arising from an interaction between the genetic makeup of the individuals and various environmental factors. Therefore, we carried out case-control studies using the candidate gene approach to investigate the association between common genetic variants in eNOS, ADD1, CYP2C8, CYP2C9, CYP2J2, CYP11B12, ACE, and AGT1 genes and essential hypertension risk in subjects of south Indian descent. As a result, I was able to show that eNOS (Glu298Asp), ACE (ID), and CYP11B2 (344C>T) are the strong candidate genes for essential hypertension while CYP2J2 for myocardial infarction in south Indians.
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Xcode Life
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United States
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Consumer Services
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1 - 100 Employee
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Senior Research Scientist
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Sept. 2016 - März 2017
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Education
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2012 - 2017
Jawaharlal Institute of Post Graduate Medical Education & Research, Puducherry
PhD, Pharmacology (Cancer Genomics and Pharmacogenomics)
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