Tyler Rouskin-Faust
Senior Scientist I at Blueprint Medicines- Claim this Profile
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Bio
Experience
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Blueprint Medicines
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United States
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Biotechnology Research
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400 - 500 Employee
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Senior Scientist I
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Jan 2023 - Present
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Scientist II
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Jun 2021 - Jan 2023
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Scientist I
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Aug 2020 - Jun 2021
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Dana-Farber Cancer Institute
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United States
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Hospitals and Health Care
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700 & Above Employee
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Research Fellow
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Jan 2017 - Aug 2020
For my postdoctoral work in the lab of Dr. Eric Fischer, I am using structural biology to uncover how a small molecule repurposes a ubiquitin ligase to degrade novel substrates. In parallel, I have created a cellular reporter library to screen for novel degradation targets. For my postdoctoral work in the lab of Dr. Eric Fischer, I am using structural biology to uncover how a small molecule repurposes a ubiquitin ligase to degrade novel substrates. In parallel, I have created a cellular reporter library to screen for novel degradation targets.
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Harvard Medical School
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United States
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Higher Education
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700 & Above Employee
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Research Fellow
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Jan 2017 - Aug 2020
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University of California, San Francisco
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United States
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Higher Education
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700 & Above Employee
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Graduate Student
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Sep 2009 - Nov 2016
My doctoral research focused on how the human immunodeficiency virus type 1 (HIV-1) transcription factor Tat hijacks host proteins to activate viral gene expression. I developed a targeted RNAi functional screen against high confidence Tat interacting proteins. By following up on hits from the screen using molecular biology, biochemistry, and virology, I demonstrated that Tat extensively exploits host ubiquitin machinery to sustain viral transcription. My doctoral research focused on how the human immunodeficiency virus type 1 (HIV-1) transcription factor Tat hijacks host proteins to activate viral gene expression. I developed a targeted RNAi functional screen against high confidence Tat interacting proteins. By following up on hits from the screen using molecular biology, biochemistry, and virology, I demonstrated that Tat extensively exploits host ubiquitin machinery to sustain viral transcription.
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University of Missouri-Columbia
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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Nov 2007 - May 2009
Used quantitative RT-PCR to determine mRNA levels in different single, identified neurons of Cancer borealis. Used quantitative RT-PCR to determine mRNA levels in different single, identified neurons of Cancer borealis.
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Princeton University
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United States
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Higher Education
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700 & Above Employee
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Summer Research Student
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Jun 2008 - Aug 2008
Performed a forward genetic screen to identify genes involved in proper C. elegans gonadogenesis. Performed a forward genetic screen to identify genes involved in proper C. elegans gonadogenesis.
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University of Missouri-Columbia
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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Jan 2007 - Aug 2007
Characterized a retrieval pathway from the early endosome back to the trans-Golgi network in yeast. Characterized a retrieval pathway from the early endosome back to the trans-Golgi network in yeast.
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Education
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University of California, San Francisco
Doctor of Philosophy (Ph.D.), Molecular Biology -
University of Missouri-Columbia
Bachelor of Science (B.S.), Biological Sciences