Tyler Rouskin-Faust

Senior Scientist I at Blueprint Medicines
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Contact Information
us****@****om
(386) 825-5501
Location
Brookline, Massachusetts, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 400 - 500 Employee
    • Senior Scientist I
      • Jan 2023 - Present

    • Scientist II
      • Jun 2021 - Jan 2023

    • Scientist I
      • Aug 2020 - Jun 2021

    • United States
    • Hospitals and Health Care
    • 700 & Above Employee
    • Research Fellow
      • Jan 2017 - Aug 2020

      For my postdoctoral work in the lab of Dr. Eric Fischer, I am using structural biology to uncover how a small molecule repurposes a ubiquitin ligase to degrade novel substrates. In parallel, I have created a cellular reporter library to screen for novel degradation targets. For my postdoctoral work in the lab of Dr. Eric Fischer, I am using structural biology to uncover how a small molecule repurposes a ubiquitin ligase to degrade novel substrates. In parallel, I have created a cellular reporter library to screen for novel degradation targets.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Research Fellow
      • Jan 2017 - Aug 2020

    • United States
    • Higher Education
    • 700 & Above Employee
    • Graduate Student
      • Sep 2009 - Nov 2016

      My doctoral research focused on how the human immunodeficiency virus type 1 (HIV-1) transcription factor Tat hijacks host proteins to activate viral gene expression. I developed a targeted RNAi functional screen against high confidence Tat interacting proteins. By following up on hits from the screen using molecular biology, biochemistry, and virology, I demonstrated that Tat extensively exploits host ubiquitin machinery to sustain viral transcription. My doctoral research focused on how the human immunodeficiency virus type 1 (HIV-1) transcription factor Tat hijacks host proteins to activate viral gene expression. I developed a targeted RNAi functional screen against high confidence Tat interacting proteins. By following up on hits from the screen using molecular biology, biochemistry, and virology, I demonstrated that Tat extensively exploits host ubiquitin machinery to sustain viral transcription.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • Nov 2007 - May 2009

      Used quantitative RT-PCR to determine mRNA levels in different single, identified neurons of Cancer borealis. Used quantitative RT-PCR to determine mRNA levels in different single, identified neurons of Cancer borealis.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Summer Research Student
      • Jun 2008 - Aug 2008

      Performed a forward genetic screen to identify genes involved in proper C. elegans gonadogenesis. Performed a forward genetic screen to identify genes involved in proper C. elegans gonadogenesis.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • Jan 2007 - Aug 2007

      Characterized a retrieval pathway from the early endosome back to the trans-Golgi network in yeast. Characterized a retrieval pathway from the early endosome back to the trans-Golgi network in yeast.

Education

  • University of California, San Francisco
    Doctor of Philosophy (Ph.D.), Molecular Biology
    2009 - 2016
  • University of Missouri-Columbia
    Bachelor of Science (B.S.), Biological Sciences
    2005 - 2009

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