Experience

Marlinspike Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Scientist, Computational Chemistry

  • Feb 2023 - Present



Roivant Sciences

• United States
• Biotechnology
• 100 - 200 Employee

• Investigator, Computational Biophysics

  • Nov 2021 - Nov 2022

  ◦ Built and implemented end-to-end pipeline for structure-based hit-to-lead optimization strategy for drug-like molecules utilizing refined conformational ensemble of a protein obtained by combining advanced molecular dynamics simulations and data from biophysical experiments such as NMR/HDX. ◦ Created and applied computational models for pocket detection and its ‘druggability’. ◦ Built and implemented end-to-end pipeline for structure-based hit-to-lead optimization strategy for drug-like molecules utilizing refined conformational ensemble of a protein obtained by combining advanced molecular dynamics simulations and data from biophysical experiments such as NMR/HDX. ◦ Created and applied computational models for pocket detection and its ‘druggability’.



Arizona State University

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Researcher

  • Jan 2021 - Nov 2021

  ◦ Computationally studied the relevance of intermediate and faster time scale motions in proteins which govern their function and interaction with other biochemical matter. ◦ Analyzed how protein interactions contribute towards regulating cellular pathways.

• Graduate Student Researcher

  • Aug 2014 - Dec 2020

  ◦ Analyzed the role of protein dynamics in regulating its function and evolution. ◦ Used computational models and molecular dynamics simulations to study how indirect and long-range interactions in a protein contribute towards their function and thereby govern their evolution. Studied how these interactions can be used to study disease-causing/function-altering mutations.



Indian Institute of Technology (Banaras Hindu University), Varanasi

• India
• Higher Education
• 700 & Above Employee

• Undergraduate Researcher

  • Jul 2009 - May 2014

  Studied the unzipping and shearing of DNA molecule using statistical physics. Studied the unzipping and shearing of DNA molecule using statistical physics.



Birla Institute of Technology and Science, Pilani

• India
• Higher Education
• 700 & Above Employee

• Research Internship

  • Dec 2013 - Dec 2013

  Making theoretical models of DNA unzipping and rupture. Investigated unzipping of DNA at 0 K, formulating analytic solutions and comparing with statistical solutions at finite temperature. Making theoretical models of DNA unzipping and rupture. Investigated unzipping of DNA at 0 K, formulating analytic solutions and comparing with statistical solutions at finite temperature.



University of Calcutta

• India
• Higher Education
• 300 - 400 Employee

• Summer Internship

  • May 2013 - Jul 2013

  Using phase field approach to model the polarized growth of a single cell to some external stimulus. Simulating cell dynamics, chemotaxis and cell division using Phase field approach. Using phase field approach to model the polarized growth of a single cell to some external stimulus. Simulating cell dynamics, chemotaxis and cell division using Phase field approach.



Centre for Materials for Electronics Technology (C-MET)

• India
• Research Services
• 100 - 200 Employee

• Summer Internship

  • May 2012 - Jul 2012

  Developed experimental techniques to study crystal defects in silicon wafers grown via vapor axial deposition. Developed experimental techniques to study crystal defects in silicon wafers grown via vapor axial deposition.