Medical Writer

• Mar 2022 - Present

Postdoctoral Scholar

• Oct 2021 - Jun 2022

Department of Physiology, laboratory of Baljit Khakh Studied the role of GPCRs in striatal astrocytes with focus on ATP GPCRs and how/if they regulate neuronal function Department of Physiology, laboratory of Baljit Khakh Studied the role of GPCRs in striatal astrocytes with focus on ATP GPCRs and how/if they regulate neuronal function

Predoctoral Fellow

• Sep 2015 - Sep 2021

Thesis advisor: Randy A. Hall Department of Pharmacology and Chemical Biology Dissertation title: "Investigating the role of astrocytic and seizure-associated receptor GPR37L1 in brain through proteomic and transcriptomic analyses" Research focus: Investigating the role of brain-specific GPCRs in seizure susceptibility Papers: 1. Owino, S., Giddens, M.M., Jiang, J., Nguyen, T.T., Shiu, F.H., Lala, T., Gearing, M., McCrary, M.R., Gu, X., Wei, L., Yu, S.P., Hall, R.A. (2021)… Show more Thesis advisor: Randy A. Hall Department of Pharmacology and Chemical Biology Dissertation title: "Investigating the role of astrocytic and seizure-associated receptor GPR37L1 in brain through proteomic and transcriptomic analyses" Research focus: Investigating the role of brain-specific GPCRs in seizure susceptibility Papers: 1. Owino, S., Giddens, M.M., Jiang, J., Nguyen, T.T., Shiu, F.H., Lala, T., Gearing, M., McCrary, M.R., Gu, X., Wei, L., Yu, S.P., Hall, R.A. (2021) GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke. Experimental Neurology 113719. PMID: 33839144 2. Nguyen, T.T., Dammer, E.B., Owino, S.A., Giddens, M.M., Madaras, N.S., Duong, D.M., Seyfried, N.T., Hall, R.A. (2020). Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1. Journal of Proteome Research, 19: 744-755 3. Smith, B.M., Giddens, M.M., Neil, J., Owino, S., Nguyen, T.T., Duong, D., Li, F., Hall, R.A. (2017). Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. Neuroscience 358: 49-57. Posters and talks: 1. Proteomic analyses reveal that glia-specific and seizure-protective receptors GPR37L1 and GPR37 regulate S100A calcium-binding protein expression and secretion. Keystone Symposia – Neural Environment in Disease: Glial Responses and Neuroinflammation. (June 2019) (poster and short talk) 2. "Seizure-protective Receptors GPR37L1 and GPR37 Regulate Calcium-binding Protein S100A5 Expression and Secretion." ASPET at Experimental Biology (San Diego, CA). 2018. (poster) 3. "Regulation of S100A5 expression and secretion by seizure-associated receptors GPR37L1 and GPR37." The Society for Neuroscience Conference (Washington, D.C.). 2017. (poster) 4. "Regulation of S100A5 expression and secretion by seizure-associated receptors GPR37L1 and GPR37." Emory MSP Research Symposium (Atlanta, GA). 2017. (poster) Show less Thesis advisor: Randy A. Hall Department of Pharmacology and Chemical Biology Dissertation title: "Investigating the role of astrocytic and seizure-associated receptor GPR37L1 in brain through proteomic and transcriptomic analyses" Research focus: Investigating the role of brain-specific GPCRs in seizure susceptibility Papers: 1. Owino, S., Giddens, M.M., Jiang, J., Nguyen, T.T., Shiu, F.H., Lala, T., Gearing, M., McCrary, M.R., Gu, X., Wei, L., Yu, S.P., Hall, R.A. (2021)… Show more Thesis advisor: Randy A. Hall Department of Pharmacology and Chemical Biology Dissertation title: "Investigating the role of astrocytic and seizure-associated receptor GPR37L1 in brain through proteomic and transcriptomic analyses" Research focus: Investigating the role of brain-specific GPCRs in seizure susceptibility Papers: 1. Owino, S., Giddens, M.M., Jiang, J., Nguyen, T.T., Shiu, F.H., Lala, T., Gearing, M., McCrary, M.R., Gu, X., Wei, L., Yu, S.P., Hall, R.A. (2021) GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke. Experimental Neurology 113719. PMID: 33839144 2. Nguyen, T.T., Dammer, E.B., Owino, S.A., Giddens, M.M., Madaras, N.S., Duong, D.M., Seyfried, N.T., Hall, R.A. (2020). Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1. Journal of Proteome Research, 19: 744-755 3. Smith, B.M., Giddens, M.M., Neil, J., Owino, S., Nguyen, T.T., Duong, D., Li, F., Hall, R.A. (2017). Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. Neuroscience 358: 49-57. Posters and talks: 1. Proteomic analyses reveal that glia-specific and seizure-protective receptors GPR37L1 and GPR37 regulate S100A calcium-binding protein expression and secretion. Keystone Symposia – Neural Environment in Disease: Glial Responses and Neuroinflammation. (June 2019) (poster and short talk) 2. "Seizure-protective Receptors GPR37L1 and GPR37 Regulate Calcium-binding Protein S100A5 Expression and Secretion." ASPET at Experimental Biology (San Diego, CA). 2018. (poster) 3. "Regulation of S100A5 expression and secretion by seizure-associated receptors GPR37L1 and GPR37." The Society for Neuroscience Conference (Washington, D.C.). 2017. (poster) 4. "Regulation of S100A5 expression and secretion by seizure-associated receptors GPR37L1 and GPR37." Emory MSP Research Symposium (Atlanta, GA). 2017. (poster) Show less

Postbaccalaureate IRTA Fellow

• Sep 2013 - Jul 2015

National Institutes of Health Fischbeck Laboratory Advisor: Kenneth Fischbeck, M.D. Neurogenetics Branch Investigated astrocyte-neuron interactions and astrocytic contribution to Spinal Muscular Atrophy (SMA) pathology Papers: Nguyen, T.T.*, Martin, J.E.*, Grunseich, C., Nofzinger, JH., Lee, P.R., Fields, D., Fischbeck, K.H., Foran, E. (2017). Decreased motor neuron support by SMA astrocytes due to diminished MCP1 secretion. The Journal of Neuroscience, 37(21):… Show more National Institutes of Health Fischbeck Laboratory Advisor: Kenneth Fischbeck, M.D. Neurogenetics Branch Investigated astrocyte-neuron interactions and astrocytic contribution to Spinal Muscular Atrophy (SMA) pathology Papers: Nguyen, T.T.*, Martin, J.E.*, Grunseich, C., Nofzinger, JH., Lee, P.R., Fields, D., Fischbeck, K.H., Foran, E. (2017). Decreased motor neuron support by SMA astrocytes due to diminished MCP1 secretion. The Journal of Neuroscience, 37(21): 5309-5318. Posters: 1. "Astrocytes isolated from transgenic delta7 SMA mice have altered protein secretion." 18th International Spinal Muscular Atrophy Research Meeting (Washington, D.C.) 2014. 2. "Astrocytes isolated from transgenic delta7 SMA mice have altered protein secretion." Society for Neuroscience 44th Annual Meeting (Washington, D.C.) 2014. 3. "The altered secretion profile of SMN-deficient astrocytes leads to decreased motor neuron growth." NIH Postbac Poster Day (Bethesda, MD) 2015. 4. "SMN-deficient astrocytes negatively impact motor neuron neurite outgrowth." Cure SMA – SMA Researcher Meeting (Kansas City, MO) 2015. Show less National Institutes of Health Fischbeck Laboratory Advisor: Kenneth Fischbeck, M.D. Neurogenetics Branch Investigated astrocyte-neuron interactions and astrocytic contribution to Spinal Muscular Atrophy (SMA) pathology Papers: Nguyen, T.T.*, Martin, J.E.*, Grunseich, C., Nofzinger, JH., Lee, P.R., Fields, D., Fischbeck, K.H., Foran, E. (2017). Decreased motor neuron support by SMA astrocytes due to diminished MCP1 secretion. The Journal of Neuroscience, 37(21):… Show more National Institutes of Health Fischbeck Laboratory Advisor: Kenneth Fischbeck, M.D. Neurogenetics Branch Investigated astrocyte-neuron interactions and astrocytic contribution to Spinal Muscular Atrophy (SMA) pathology Papers: Nguyen, T.T.*, Martin, J.E.*, Grunseich, C., Nofzinger, JH., Lee, P.R., Fields, D., Fischbeck, K.H., Foran, E. (2017). Decreased motor neuron support by SMA astrocytes due to diminished MCP1 secretion. The Journal of Neuroscience, 37(21): 5309-5318. Posters: 1. "Astrocytes isolated from transgenic delta7 SMA mice have altered protein secretion." 18th International Spinal Muscular Atrophy Research Meeting (Washington, D.C.) 2014. 2. "Astrocytes isolated from transgenic delta7 SMA mice have altered protein secretion." Society for Neuroscience 44th Annual Meeting (Washington, D.C.) 2014. 3. "The altered secretion profile of SMN-deficient astrocytes leads to decreased motor neuron growth." NIH Postbac Poster Day (Bethesda, MD) 2015. 4. "SMN-deficient astrocytes negatively impact motor neuron neurite outgrowth." Cure SMA – SMA Researcher Meeting (Kansas City, MO) 2015. Show less

Help Desk Technician

• Aug 2011 - May 2013

General computer troubleshooting including malware removal, network activation, file transfers, back ups, installations, and rebuilds. General computer troubleshooting including malware removal, network activation, file transfers, back ups, installations, and rebuilds.

Undergraduate Research Fellow

• Jan 2011 - May 2013

Advisor: Eranthie Weerapana, Ph.D. Chemistry Department Boston College Pursued an independent project that investigated the effects of the modification and mutation of putative reactive cysteine residues implicated in the self-insertion ability of chloride ion channels, CLIC1 and CLIC4, through a structure-function study utilizing site-directed mutagenesis. Advisor: Eranthie Weerapana, Ph.D. Chemistry Department Boston College Pursued an independent project that investigated the effects of the modification and mutation of putative reactive cysteine residues implicated in the self-insertion ability of chloride ion channels, CLIC1 and CLIC4, through a structure-function study utilizing site-directed mutagenesis.

Undergraduate Research Assistant

• Aug 2011 - Apr 2012

Advisor: Thomas Seyfried, Ph.D. Boston College Performed behavioral tests on Mus musculus mice (strains EL, DDY, Hex-B, and Beta-gal) as well as dissection for harvesting of sciatic and optic nerves. Advisor: Thomas Seyfried, Ph.D. Boston College Performed behavioral tests on Mus musculus mice (strains EL, DDY, Hex-B, and Beta-gal) as well as dissection for harvesting of sciatic and optic nerves.

Undergraduate Research Assistant

• Dec 2010 - May 2011

Research Assistant

• Aug 2010 - Mar 2011

Advisor: Lisa Feldman Barrett, Ph.D. Boston College Ran double blind studies on participants for a study looking at the effect of voice affect and perception. Advisor: Lisa Feldman Barrett, Ph.D. Boston College Ran double blind studies on participants for a study looking at the effect of voice affect and perception.