Tien Yin Yau
Senior Scientist at Everest Detection- Claim this Profile
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Spanish Elementary proficiency
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English Native or bilingual proficiency
Topline Score
Bio
Experience
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Everest Detection
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Research
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1 - 100 Employee
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Senior Scientist
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Apr 2019 - Present
o Designed experiments to identify non-invasive molecular biomarkers in early cancer. o Built database to capture, track, and associate clinical data, experimental design parameters and analytical results. o Isolated nucleic acids from clinical biosamples, built sequencing libraries, analyzed NGS sequencing results using Excel, python scripts, and altair graphs. o Built interactive graphs to allow for data exploration and investigation using jupyter notebooks, Altair, and ipywidgets o Co-ordinated with CROs. Show less
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Deepcell, Inc.
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United States
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Biotechnology Research
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1 - 100 Employee
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Senior Scientist
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Jan 2019 - Apr 2019
o Designed, validated, and optimized assays for our diagnostic blood tests (qPCR, NGS, single-cell analysis, microarray). o Piloted novel analysis techniques, interpreted data, and presented to the team. o Designed, validated, and optimized assays for our diagnostic blood tests (qPCR, NGS, single-cell analysis, microarray). o Piloted novel analysis techniques, interpreted data, and presented to the team.
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Scientist II
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Sep 2017 - Jan 2019
o Piloted implementation of 10x single cell RNA-seq technology at Abbvie-Stemcentrx. Prepared all sequencing libraries.o Investigated the feasibility of using CITE-Seq to determine paired protein and transcriptome expression at the single-cell level.
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Scientist I
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Jun 2016 - Sep 2017
o Wrote and maintained Python scripts that automated sample tracking and identified overlooked samples ready for different stages of processingo Validated NGS targets with qPCR (quantstudio and Biomark)
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Stemcentrx, Inc.
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United States
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Biotechnology Research
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1 - 100 Employee
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Senior Research Associate
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Mar 2015 - Jun 2016
o Isolated nucleic acids from patient derived xenografts, determined expression patterns by RNA-Seq and Microarray, and analyzed results with excel and Python (pandas). o Isolated nucleic acids from patient derived xenografts, determined expression patterns by RNA-Seq and Microarray, and analyzed results with excel and Python (pandas).
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Universty Assistant (Researcher)
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Feb 2011 - Dec 2014
o Designed and produced transgenic mice using ES cells, lentiviral and transposon vectors, and pronuclear injection. o Analyzed transgenic mice with fluorescence microscopy, in-vivo imaging, PCR genotyping, qPCR, and Southern/Northern/Western blots. o Designed and produced transgenic mice using ES cells, lentiviral and transposon vectors, and pronuclear injection. o Analyzed transgenic mice with fluorescence microscopy, in-vivo imaging, PCR genotyping, qPCR, and Southern/Northern/Western blots.
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Prostate Cancer Research Centre
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Research Services
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1 - 100 Employee
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Masters Student
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Sep 2006 - Feb 2010
o Studied the role of the phosphatidylinositol-3-kinase pathway in disease using cancer cell lines, mammalian cell transfection, and murine models.o Determined the effects of small molecule drugs on these diseases.
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Laboratory Assistant
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Sep 2004 - Aug 2006
o Produced and purified transgenic protein using bacterial and mammalian cell transfection (Transient and Lentiviral).o Determined the effect of a novel small molecule drug on inhibiting progression of hematopoietic cancers.
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SemBioSys Genetics Inc.
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Biotechnology
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1 - 100 Employee
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Laboratory Assistant
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May 2004 - Aug 2004
o Worked independently to clone, express, and characterize a novel protein for in house use o Constructed vectors, transformed bacteria, analyzed protein expression and purified protein. o Worked independently to clone, express, and characterize a novel protein for in house use o Constructed vectors, transformed bacteria, analyzed protein expression and purified protein.
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Laboratory Assistant
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Jan 2003 - Aug 2003
o Isolated and cultivated fungi from wood samples; DNA isolation, amplification, purification, cloning, sequencing, and sequence analysis. o Developed an electronic fungal database: Organized and led database meetings. o Isolated and cultivated fungi from wood samples; DNA isolation, amplification, purification, cloning, sequencing, and sequence analysis. o Developed an electronic fungal database: Organized and led database meetings.
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Laboratory Assistant
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May 2002 - Aug 2002
o Identified mites using a dissection microscope; data entry & analysis o Identified mites using a dissection microscope; data entry & analysis
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Undergraduate Academic Assistant
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May 2002 - Aug 2002
o Analyzed client protein samples using a MALDI-TOF mass spectrometer o Sequenced client DNA and protein samples using automated sequencers o Analyzed client protein samples using a MALDI-TOF mass spectrometer o Sequenced client DNA and protein samples using automated sequencers
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Laboratory Assistant
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Nov 2000 - Aug 2001
o In vitro Tissue Culture: Micropropagation, Meristerm culture, virus elimination and Cryopreservation o Potato DNA extraction and fingerprinting by microsatellite marker o In vitro Tissue Culture: Micropropagation, Meristerm culture, virus elimination and Cryopreservation o Potato DNA extraction and fingerprinting by microsatellite marker
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Laboratory Assistant
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Oct 2000 - Mar 2001
o Performed micropropagation in orchid, pineapple, banana, African violets, and meristem culture in banana. o Performed micropropagation in orchid, pineapple, banana, African violets, and meristem culture in banana.
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Laboratory Assistant
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May 2000 - Jun 2000
o Investigate the effect of habitat on behavior of Julidochromis marlieri. o Investigate the effect of habitat on behavior of Julidochromis marlieri.
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Education
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The University of British Columbia / UBC
Master of Science (M.Sc.), Genetics -
The University of British Columbia / UBC
Bachelor of Science (B.Sc.), Cell Biology and Genetics