Experience

Pretzel Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• SVP - Head of Biology

  • 2023 - Present

  Waltham, Massachusetts, United States



Ginkgo Bioworks, Inc.

• United States
• Biotechnology Research
• 700 & Above Employee

• Senior Director, Drug Discovery

  • 2020 - 2023

  Boston, Massachusetts, United States



ImmunoGen, Inc.

• United States
• Biotechnology Research
• 200 - 300 Employee

• Senior Director of Biochemistry

  • 2016 - 2019

  Waltham, Massachusetts, United States Department head for antibody-drug conjugations targeting cancer. Leading scientists, projects, and portfolio in the ADC field: - Antibody-drug conjugations, analysis, and characterization - New linker technology, including site-specific conjugations and novel payloads - Internal drug discovery projects - Partnered and collaborative discovery projects

• Director of Biochemistry

  • 2014 - 2016

  Waltham, Massachusetts, United States



AstraZeneca

• United Kingdom
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Principal Scientist I

  • 2007 - 2014

  Waltham, Massachusetts, United States Team leader for Infection Biophysics group and for In Vitro Virology. Project leader for antibiotic drug discovery: led thymidylate kinase project from target ID to late lead optimization. Project management: supporting and writing NDA filing for AVYCAZ (ceftazidime-avibactam, Phase III) by contracting and managing internal and external scientific studies. Led “line-of-sight” team in developing clinical, regulatory, and commercial cases for Infection early development projects. Function… Show more Team leader for Infection Biophysics group and for In Vitro Virology. Project leader for antibiotic drug discovery: led thymidylate kinase project from target ID to late lead optimization. Project management: supporting and writing NDA filing for AVYCAZ (ceftazidime-avibactam, Phase III) by contracting and managing internal and external scientific studies. Led “line-of-sight” team in developing clinical, regulatory, and commercial cases for Infection early development projects. Function lead for global data processing and storage initiatives. Externalization: managing collaborative discovery projects (BioFocus, UK, and ETC, Singapore), and CRO scientists for internal projects. Due diligence team for Infection external acquisitions. Bioscience lead generation: led multidisciplinary group in developing new target-based screening strategies through assay development and screening. Core member Infection Lead Generation, responsible for new projects, strategy, and pipeline delivery. Biochemical contributions to early and late-stage discovery projects: chemical and kinetic enzyme reaction mechanisms, protein biophysical characterization (ITC), competitive binding assays, high-throughput screening assay development and delivery, project database and cascade management.

• Senior Scientist

  • 2005 - 2007

  Waltham, Massachusetts, United States

• Scientist

  • 2001 - 2005

  Waltham, Massachusetts, United States



Harvard Medical School

• United States
• Higher Education
• 700 & Above Employee

• Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellow

  • 1998 - 2001

  Boston, MA Prof. Christopher T. Walsh Research Group Biochemistry of non-ribosomal peptide synthesis. Identification, cloning, expression, and enzymatic characterization of peptide synthetases. Published on several pathogenic bacterial iron-acquisition systems, including mycobactin, yersiniabactin, and vibrobactin. X-ray crystal structure of the first NRPS condensation enzyme.