Experience

Universidade Federal de Santa Catarina

• Brazil
• Higher Education
• 700 & Above Employee

• Professor

  • Dec 2015 - Present

• Postdoctoral researcher

  • May 2014 - Nov 2015

  Investigations involving the drug administration/delivery through skin. Teaching activities in Pharmaceutical Technology and Quality Control.



Universidade Federal de Santa Catarina

• Brazil
• Higher Education
• 700 & Above Employee

• Researcher (Scientific Initiation, Masters Degree and Doctorate)

  • Mar 2004 - Mar 2014

  SCIENTIFIC INITIATION: research on the antiviral compounds, cytotoxic, central nervous system depressant, anti-inflammatory, antioxidant and with activity in the cardiovascular system. Chemical and pharmacological studies aiming at obtaining herbal medicine. The results of many of these studies may have their application in the pharmaceutical industry, by developing new drugs or enhancing product quality already existing in the market. MASTERS: standardization of the Franz diffusion cell for permeability studies of drugs and excipients through buccal and esophageal mucosae, just as pig ear skin. This innovative project may take to the introduction of pharmaceutical mucoadhesive preparations to the Brazilian market. The usage of a buccal mucosa for the drug administration, targeting local action, is recent. Up until now, there is only a mucoadhesive in the global market approved by FDA: the Aftach® (used for aphthous stomatitis). This study had a multidisciplinary and challenging profile, involving areas such as Pharmaceutical Technology, Quality Control and Analytical Chemistry. DOCTORATE: Approach development from pharmaceutical technology aiming at improving biopharmaceutical characteristics from saquinavir mesylate, an anti-retroviral used in AIDS treatment. This study aimed at reducing production costs of this drug as well as the improvement of intestinal absorption from the active compound of this product. If this hypothesis is confirmed, several advantages would be observed: greater adherence to treatment, lower production costs, reduction of undesirable side-effects, among others. Show less



Monash University

• Australia
• Higher Education
• 700 & Above Employee

• Visiting Researcher

  • Dec 2012 - Aug 2013

  Ex vivo buccal permeability studies for different drugs (diffusion model used: Ussing chambers / membrane model: porcine buccal epithelium). Different chemical absorption enhancers were considered in order to improve the buccal permeability of these drugs; including mechanistic studies. Ex vivo buccal permeability studies for different drugs (diffusion model used: Ussing chambers / membrane model: porcine buccal epithelium). Different chemical absorption enhancers were considered in order to improve the buccal permeability of these drugs; including mechanistic studies.



Federal University of Rio Grande do Sul

• Higher Education
• 700 & Above Employee

• Pesquisador/doutorando no Laboratório de Desenvolvimento Galênico (LDG)

  • Aug 2010 - Mar 2011

  Preparo e caracterização físico-química de dispersões sólidas orais de mesilato de saquinavir. Preparações sob diferentes condições de processamento e armazenagem foram obtidas e otimizadas quanto a suas propriedades de dissolução. Preparo e caracterização físico-química de dispersões sólidas orais de mesilato de saquinavir. Preparações sob diferentes condições de processamento e armazenagem foram obtidas e otimizadas quanto a suas propriedades de dissolução.



Nanovetores S.A.

• Brazil
• Chemical Manufacturing
• 1 - 100 Employee

• Researcher

  • Mar 2010 - Jan 2011

  Planning, execution and results analysis from the following experiments: - In vitro evaluation of the genotoxic potential of nanovectors by the Comet assay; - Release studies of fluorescent dyes from nanovectors with different physicochemical properties, using cellulose acetate membranes and Franz diffusion apparatus as model; - Ex vivo permeation of these same materials in the pig ear skin through the Franz diffusion cell model and quantification by fluorimetry; - Histological analysis of the skin after treatment with dye-containing nanovectors in order to verify the penetration degree in skin layers (epidermis and dermis); - Determination of the drug encapsulation efficiency by the ultracentrifugation technique. - Development of a sensitive fluorescence-based assay for the quantitative determination of fluorescent dyes. Show less



Ministério da Saúde

• Hospitals and Health Care
• 700 & Above Employee

• Technical Consultant

  • Sep 2009 - Jan 2010

  Assisting projects regarding Fito Network Restructuring. Developed tasks: bibliographical survey from plants which are part of the Medicinal Plants National List (list of regional plants representing the regional popular phytotherapy) of interest for the SUS (Brazilian National Health Care System), and critical analysis from the consulted scientific literature for elaborating monographies. This research will contribute for the identification of new research needs, draw up a National Formulary of Medicinal Plants, as well as serving as support to the National Policy on Phytopharmaceuticals and Medicinal Plants. These policies advocate the inclusion of the use of medicinal plants in primary health care, which shall be employed with highest efficacy and safety and must be object of the actions of Pharmaceutical Services, which are also to be applied to manufactured drugs. Show less



Communication and Information Technology Laboratory

• Florianópolis, Santa Catarina, Brazil

• Monitor

  • Mar 2009 - Jul 2009

  Task support development to professors Task support development to professors



Laboratory of Capillary Electrophoresis

• Florianópolis, Santa Catarina, Brazil

• Researcher/Master

  • 2008 - 2009

  Master: use of capillary electrophoresis (CE) as tool for the quantitative determination of drugs and excipients. Analytical methods development and validation. Researcher: analytical methods development and validation, quality control of raw materials, studies involving the natural products development. Implementation of new methods in the laboratory. Master: use of capillary electrophoresis (CE) as tool for the quantitative determination of drugs and excipients. Analytical methods development and validation. Researcher: analytical methods development and validation, quality control of raw materials, studies involving the natural products development. Implementation of new methods in the laboratory.



Fórmula Indicada Prescription Pharmacy

• Florianópolis, Santa Catarina, Brazil

• Mandatory Intership

  • Mar 2006 - Jul 2006

  Developed tasks: tasks related to drug handling in the Laboratory of Solids, Semi-solids and Liquids, Quality Control. Drugs handling for veterinary use: checking medical prescriptions (specially for those controlled drugs) and therapeutic regime, monitoring of production orders and new raw-material acquisition procedures, supplier’s records, pharmaceutical products handling, preliminary tests for quality control and for the production of new formulations, pharmaceutical care. Developed tasks: tasks related to drug handling in the Laboratory of Solids, Semi-solids and Liquids, Quality Control. Drugs handling for veterinary use: checking medical prescriptions (specially for those controlled drugs) and therapeutic regime, monitoring of production orders and new raw-material acquisition procedures, supplier’s records, pharmaceutical products handling, preliminary tests for quality control and for the production of new formulations, pharmaceutical care.



Essentia Pharmacy

• Volunteer Internship

  • Dec 2005 - Mar 2006

  Tasks related to drug handling in the Laboratory of Solids. Knowledge of manufacturing processes (every step involved in the conversion of the active drugs into products suitable for administration). Tasks related to drug handling in the Laboratory of Solids. Knowledge of manufacturing processes (every step involved in the conversion of the active drugs into products suitable for administration).



Laboratory of Mycotoxins (Federal University of Santa Catarina)

• Florianópolis, Santa Catarina, Brazil

• Trainee

  • 2003 - 2004

  Extraction of fungal toxin (eg, patulin, aflatoxin, fumonisin) from foods in order to ensure their quality. Training of new trainees. Preparation and review of Standard Operating Procedures (SOPs) according to the quality system. Extraction of fungal toxin (eg, patulin, aflatoxin, fumonisin) from foods in order to ensure their quality. Training of new trainees. Preparation and review of Standard Operating Procedures (SOPs) according to the quality system.