Talia DeFrancesco Oranburg
Variant Curation Scientist at Ariel Precision Medicine- Claim this Profile
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Bio
Experience
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Ariel Precision Medicine
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United States
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Biotechnology
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1 - 100 Employee
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Variant Curation Scientist
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Mar 2023 - Present
I work on curating genetic variants and interpreting their significance to report to patients and physicians in an effort to target and improve clinical care. I work on curating genetic variants and interpreting their significance to report to patients and physicians in an effort to target and improve clinical care.
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University of Pittsburgh School of Public Health
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United States
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Higher Education
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100 - 200 Employee
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Graduate Student Researcher
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Aug 2018 - Feb 2023
I worked in the lab of Dr. Quasar Saleem Padiath studying a rare demyelinating disease called autosomal dominant leukodystrophy (ADLD). We know that patients show an overexpression of the nuclear lamina protein, lamin B1. To elucidate the cell-specific mechanisms of this disease I established patient-based iPSC lines and differentiated these iPSCs into the disease-relevant CNS cell types. I worked in the lab of Dr. Quasar Saleem Padiath studying a rare demyelinating disease called autosomal dominant leukodystrophy (ADLD). We know that patients show an overexpression of the nuclear lamina protein, lamin B1. To elucidate the cell-specific mechanisms of this disease I established patient-based iPSC lines and differentiated these iPSCs into the disease-relevant CNS cell types.
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Fourth River Solutions
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United States
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Business Consulting and Services
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1 - 100 Employee
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Consultant
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Jan 2021 - Dec 2022
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Ariel Precision Medicine
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United States
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Biotechnology
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1 - 100 Employee
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Variant Curation Intern
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Feb 2022 - Sep 2022
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New York University School of Law
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United States
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Higher Education
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300 - 400 Employee
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Research Assistant
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Sep 2017 - Jun 2019
I provided research assistance for a national study on the effect of regulation on innovation and startups. The team has also conducted interviews in Israel and London. I provided research assistance for a national study on the effect of regulation on innovation and startups. The team has also conducted interviews in Israel and London.
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Case Western Reserve University
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United States
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Higher Education
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700 & Above Employee
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RA5
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2009 - Jul 2017
The Zigmond lab studies peripheral nerve regeneration and the interaction of immune cells in this process. Here I managed the lab, trained new lab members and performed experiments in histology, imaging, data analysis, biochemical analysis, mouse work and microsurgery. The Zigmond lab studies peripheral nerve regeneration and the interaction of immune cells in this process. Here I managed the lab, trained new lab members and performed experiments in histology, imaging, data analysis, biochemical analysis, mouse work and microsurgery.
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University of Pittsburgh
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United States
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Higher Education
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700 & Above Employee
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Research Specialist
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May 2004 - Jan 2010
Training new lab members, managing the lab supplies and purchases, performing microdialysis experiments including surgeries and histology. Training new lab members, managing the lab supplies and purchases, performing microdialysis experiments including surgeries and histology.
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SCI Cambridge Springs
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Cambridge Springs, Pennsylvania
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Addiction and Therapeutic Intervention Intern
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Jan 2003 - May 2003
SCI Cambridge Springs is a minimum-security women's prison. Here I worked in the drug and alcohol rehabilitation unit assisting inmates with recovery from addiction and trauma and transformation to life outside of prison. SCI Cambridge Springs is a minimum-security women's prison. Here I worked in the drug and alcohol rehabilitation unit assisting inmates with recovery from addiction and trauma and transformation to life outside of prison.
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Education
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University of Pittsburgh
post-bac studies, Organic Chemistry, Calculus, Anatomy -
Case Western Reserve University School of Medicine
post-bac studies, Pathology -
Neve Yerushalayim
Jewish Studies -
Allegheny College
BS, Neuroscience/Psychology -
University of Pittsburgh
Doctor of Philosophy - PhD, Human/Medical Genetics