Susanne Saalau
Vice President Biochemistry and Biophysics at Photys Therapeutics- Claim this Profile
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German Native or bilingual proficiency
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Bio
Experience
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Photys Therapeutics
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United States
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Biotechnology
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1 - 100 Employee
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Vice President Biochemistry and Biophysics
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May 2022 - Present
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Frontier Medicines
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United States
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Biotechnology Research
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1 - 100 Employee
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Executive Director, Discovery Biology
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Dec 2021 - Apr 2022
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LifeMine Therapeutics
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United States
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Biotechnology
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1 - 100 Employee
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Vice President
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Jun 2020 - Dec 2021
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Senior Director, Biochemistry & Screening
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May 2018 - Jun 2020
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FogPharma
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United States
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Biotechnology Research
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100 - 200 Employee
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Senior Director, Biochemistry & Screening
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May 2018 - Jul 2018
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Astex Pharmaceuticals, Inc. (US)
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United States
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Director Molecular Science
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Mar 2012 - Jun 2017
Lead a variety of internal and collaboration projects aimed at discovering new chemical starting points to effect the modulation of target proteins for the treatment of diseases of high unmet medical need. Managed a group of PhD level Biophysics experts to perform fragment screens and support hits to leads, lead optimisation and pre-clinical candidate selection phase projects. Responsibilities included construct design, cloning, expression and purification of relevant proteins to support… Show more Lead a variety of internal and collaboration projects aimed at discovering new chemical starting points to effect the modulation of target proteins for the treatment of diseases of high unmet medical need. Managed a group of PhD level Biophysics experts to perform fragment screens and support hits to leads, lead optimisation and pre-clinical candidate selection phase projects. Responsibilities included construct design, cloning, expression and purification of relevant proteins to support crystallography, ITC, SPR and biosassay screens, characterisation of the proteins in solution and interactions with ligands, and the design and execution of mode of action studies to enable the discovery of first and/or best in class drug molecules. Show less Lead a variety of internal and collaboration projects aimed at discovering new chemical starting points to effect the modulation of target proteins for the treatment of diseases of high unmet medical need. Managed a group of PhD level Biophysics experts to perform fragment screens and support hits to leads, lead optimisation and pre-clinical candidate selection phase projects. Responsibilities included construct design, cloning, expression and purification of relevant proteins to support… Show more Lead a variety of internal and collaboration projects aimed at discovering new chemical starting points to effect the modulation of target proteins for the treatment of diseases of high unmet medical need. Managed a group of PhD level Biophysics experts to perform fragment screens and support hits to leads, lead optimisation and pre-clinical candidate selection phase projects. Responsibilities included construct design, cloning, expression and purification of relevant proteins to support crystallography, ITC, SPR and biosassay screens, characterisation of the proteins in solution and interactions with ligands, and the design and execution of mode of action studies to enable the discovery of first and/or best in class drug molecules. Show less
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Astex Therapeutics
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United Kingdom
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Biotechnology Research
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1 - 100 Employee
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Associate Director
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Jul 2003 - Mar 2012
Key responsibilities: Project leadership of internal and collaborative drug discovery programs during structure determination, fragment screening and hits to leads phases. Protein expression, purification and characterisation for structure elucidation and mechanistic studies Validation of biochemical /in vivo significance of novel allosteric sites either in house or through academic collaborations. Key achievements include determination of novel protein structures, discovery of… Show more Key responsibilities: Project leadership of internal and collaborative drug discovery programs during structure determination, fragment screening and hits to leads phases. Protein expression, purification and characterisation for structure elucidation and mechanistic studies Validation of biochemical /in vivo significance of novel allosteric sites either in house or through academic collaborations. Key achievements include determination of novel protein structures, discovery of novel allosteric sites on two separate systems and identification of compounds currently in advanced clinical trials. Show less Key responsibilities: Project leadership of internal and collaborative drug discovery programs during structure determination, fragment screening and hits to leads phases. Protein expression, purification and characterisation for structure elucidation and mechanistic studies Validation of biochemical /in vivo significance of novel allosteric sites either in house or through academic collaborations. Key achievements include determination of novel protein structures, discovery of… Show more Key responsibilities: Project leadership of internal and collaborative drug discovery programs during structure determination, fragment screening and hits to leads phases. Protein expression, purification and characterisation for structure elucidation and mechanistic studies Validation of biochemical /in vivo significance of novel allosteric sites either in house or through academic collaborations. Key achievements include determination of novel protein structures, discovery of novel allosteric sites on two separate systems and identification of compounds currently in advanced clinical trials. Show less
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Pfizer
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United States
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Pharmaceutical Manufacturing
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700 & Above Employee
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Principal Scientist. Team/Group Leader
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Mar 2000 - Jun 2003
Key responsibilities: Supervision of team of biologist to provide technical and scientific support to the therapeutic area in the fields of automation, assay development, miniaturisation, protein purification and biomarker identification. Screening of compounds against all PDE isozymes to identify potent and selective drug molecules. Develop robust assays for medium throughput screens (up to 10000cpds). Coordinated work alongside interdisciplinary colleagues to nominate drug… Show more Key responsibilities: Supervision of team of biologist to provide technical and scientific support to the therapeutic area in the fields of automation, assay development, miniaturisation, protein purification and biomarker identification. Screening of compounds against all PDE isozymes to identify potent and selective drug molecules. Develop robust assays for medium throughput screens (up to 10000cpds). Coordinated work alongside interdisciplinary colleagues to nominate drug candidates Tissue typing of different human and animal organs to determine presence and distribution of PDE isozymes. Key achievement included the proposal of improved compound supply for biological testing that would minimise compound wastage. Improved purification yields of PDE isozymes from animal tissues to support selectivity screens and candidate selection Show less Key responsibilities: Supervision of team of biologist to provide technical and scientific support to the therapeutic area in the fields of automation, assay development, miniaturisation, protein purification and biomarker identification. Screening of compounds against all PDE isozymes to identify potent and selective drug molecules. Develop robust assays for medium throughput screens (up to 10000cpds). Coordinated work alongside interdisciplinary colleagues to nominate drug… Show more Key responsibilities: Supervision of team of biologist to provide technical and scientific support to the therapeutic area in the fields of automation, assay development, miniaturisation, protein purification and biomarker identification. Screening of compounds against all PDE isozymes to identify potent and selective drug molecules. Develop robust assays for medium throughput screens (up to 10000cpds). Coordinated work alongside interdisciplinary colleagues to nominate drug candidates Tissue typing of different human and animal organs to determine presence and distribution of PDE isozymes. Key achievement included the proposal of improved compound supply for biological testing that would minimise compound wastage. Improved purification yields of PDE isozymes from animal tissues to support selectivity screens and candidate selection Show less
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GSK
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United Kingdom
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Pharmaceutical Manufacturing
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700 & Above Employee
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Principal Research Scientist and Project leader
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Oct 1990 - Feb 2000
Responsibilities included: Project leader for various in house anti-viral projects, including HCV targets. Protein purification, biophysical characterisation and crystallisation for proteins of interest across numerous therapeutic areas. Supply of protein for high throughput screening and or mechanistic elucidation. Senior structural biologist representative and deputy project leader on a variety of projects. Introduced and managed the analytical ultracentrifugation facility and… Show more Responsibilities included: Project leader for various in house anti-viral projects, including HCV targets. Protein purification, biophysical characterisation and crystallisation for proteins of interest across numerous therapeutic areas. Supply of protein for high throughput screening and or mechanistic elucidation. Senior structural biologist representative and deputy project leader on a variety of projects. Introduced and managed the analytical ultracentrifugation facility and performed experiments for in-house projects as well as collaborative targets. Show less Responsibilities included: Project leader for various in house anti-viral projects, including HCV targets. Protein purification, biophysical characterisation and crystallisation for proteins of interest across numerous therapeutic areas. Supply of protein for high throughput screening and or mechanistic elucidation. Senior structural biologist representative and deputy project leader on a variety of projects. Introduced and managed the analytical ultracentrifugation facility and… Show more Responsibilities included: Project leader for various in house anti-viral projects, including HCV targets. Protein purification, biophysical characterisation and crystallisation for proteins of interest across numerous therapeutic areas. Supply of protein for high throughput screening and or mechanistic elucidation. Senior structural biologist representative and deputy project leader on a variety of projects. Introduced and managed the analytical ultracentrifugation facility and performed experiments for in-house projects as well as collaborative targets. Show less
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Education
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Pennsylvania State University-State College campus
Biophysical Chemistry -
United States Naval Academy
Chemistry