Stephen Shimshock
Principal Scientist at Polysciences, Inc.- Claim this Profile
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Bio
Wayne Leonard
Steve is a pro! and a pleasure to work with. Always has time to help a new chemist or tech. A really good guy.
Yuriko Suzuki, Ph.D
I had the pleasure of working with Steve at sanofi-aventis, internal medicine TD and fibrosis and wound repair TSU. Steve was leading enzyme and receptor projects as project leader in internal medicine TD. I was always impressed by him how handle the project and chemistry plan. When we worked in Fibrosis and Wound repair TSU, Steve and I co-lead for an orphan GPCR project. The project was under exciting stage to validate target with compounds in vivo. We have to develop unique strategy for the project plan compare to well validated target in both biology and chemistry. Steve led chemistry part very professionally by using his knowledge form his extensive experience and flexibly adjusted the plan to the unique situation, too. He also quickly catches up the biology part and gives good input for the biology team. I enjoyed co-leading the project with him and happy to work together anytime and any projects again in the future. He is the expert senior chemistry leader who anyone will be appreciating the value he bring into the organization, and very professional and present person who you like to work with!
Wayne Leonard
Steve is a pro! and a pleasure to work with. Always has time to help a new chemist or tech. A really good guy.
Yuriko Suzuki, Ph.D
I had the pleasure of working with Steve at sanofi-aventis, internal medicine TD and fibrosis and wound repair TSU. Steve was leading enzyme and receptor projects as project leader in internal medicine TD. I was always impressed by him how handle the project and chemistry plan. When we worked in Fibrosis and Wound repair TSU, Steve and I co-lead for an orphan GPCR project. The project was under exciting stage to validate target with compounds in vivo. We have to develop unique strategy for the project plan compare to well validated target in both biology and chemistry. Steve led chemistry part very professionally by using his knowledge form his extensive experience and flexibly adjusted the plan to the unique situation, too. He also quickly catches up the biology part and gives good input for the biology team. I enjoyed co-leading the project with him and happy to work together anytime and any projects again in the future. He is the expert senior chemistry leader who anyone will be appreciating the value he bring into the organization, and very professional and present person who you like to work with!
Wayne Leonard
Steve is a pro! and a pleasure to work with. Always has time to help a new chemist or tech. A really good guy.
Yuriko Suzuki, Ph.D
I had the pleasure of working with Steve at sanofi-aventis, internal medicine TD and fibrosis and wound repair TSU. Steve was leading enzyme and receptor projects as project leader in internal medicine TD. I was always impressed by him how handle the project and chemistry plan. When we worked in Fibrosis and Wound repair TSU, Steve and I co-lead for an orphan GPCR project. The project was under exciting stage to validate target with compounds in vivo. We have to develop unique strategy for the project plan compare to well validated target in both biology and chemistry. Steve led chemistry part very professionally by using his knowledge form his extensive experience and flexibly adjusted the plan to the unique situation, too. He also quickly catches up the biology part and gives good input for the biology team. I enjoyed co-leading the project with him and happy to work together anytime and any projects again in the future. He is the expert senior chemistry leader who anyone will be appreciating the value he bring into the organization, and very professional and present person who you like to work with!
Wayne Leonard
Steve is a pro! and a pleasure to work with. Always has time to help a new chemist or tech. A really good guy.
Yuriko Suzuki, Ph.D
I had the pleasure of working with Steve at sanofi-aventis, internal medicine TD and fibrosis and wound repair TSU. Steve was leading enzyme and receptor projects as project leader in internal medicine TD. I was always impressed by him how handle the project and chemistry plan. When we worked in Fibrosis and Wound repair TSU, Steve and I co-lead for an orphan GPCR project. The project was under exciting stage to validate target with compounds in vivo. We have to develop unique strategy for the project plan compare to well validated target in both biology and chemistry. Steve led chemistry part very professionally by using his knowledge form his extensive experience and flexibly adjusted the plan to the unique situation, too. He also quickly catches up the biology part and gives good input for the biology team. I enjoyed co-leading the project with him and happy to work together anytime and any projects again in the future. He is the expert senior chemistry leader who anyone will be appreciating the value he bring into the organization, and very professional and present person who you like to work with!
Experience
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Polysciences, Inc.
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United States
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Biotechnology Research
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100 - 200 Employee
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Principal Scientist
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2015 - Present
-Custom synthesis of specialty monomers and polymers for medical devices, coatings, lens.-Developed efficient, safe, and robust, cGMP kilo-scale, syntheses of specialty monomers and polymers.-Optimized cGMP suspension polymerization of bioresorbable microspheres for drug delivery-Utilized chemical expertise and analytical techniques to optimize yields/purity and minimize trace impurities formed during syntheses.-Discovery and development project team leader, experience working with cross-functional teams. -Good oral/written communication skills. Technical liaison between management and customer. Authors and presents technical reports to internal and external customers.
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Senior Chemist
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2013 - 2015
-Custom synthesis and production of specialty monomers and polymers for medical devices, coatings, stents.-Expertise in synthesis of PLGA-based bioresorbable polymers.-Expertise in variety of polymerization techniques (bulk, free-radical solution, ring-opening, and suspension)
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Sanofi
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France
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Pharmaceutical Manufacturing
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700 & Above Employee
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Fibrosis Chemistry Project Team Leader/Lead Research Investigator
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2011 - 2013
-Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of fibrosis.-Supervised group of 5 chemists within Fibrosis & Wound Repair TSU-Medicinal chemist on multi-kinase inhibitor project team-Member of Target-to-Advanced Lead Oversight Committee-Member of Wound Healing/Scarring Working Group-Member of Bridgewater HAZMAT Team
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Exploratory and Internal Medicine Chemistry Project Team Leader / Lead Research Investigator
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2006 - 2011
-Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of RA, asthma, and CV disease.-Chemistry Project Team Co-Leader for chemokine receptor antagonist project-Chemistry Project Team Co-Leader for estrogen receptor antagonist project-Member of chemistry leadership team for Exploratory and Internal Medicine TSU.-Member of Lead Acceptance Team (LAC)-Member of Bridgewater site HAZMAT team
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Principal Research Investigator, Medicinal Chemistry Department
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2000 - 2005
-Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of RA, asthma, and CNS diseases.-Chemistry Project team co-leader for metalloprotease inhibitor team-Medicinal chemist on prostaglandin receptor antagonist team-Medicinal chemist on serine protease inhibitor team-Medicinal chemist on Protein-Protein Interactions team-Leader of Bridgewater Science Education Outreach Committee -Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of RA, asthma, and CNS diseases.-Chemistry Project team co-leader for metalloprotease inhibitor team-Medicinal chemist on prostaglandin receptor antagonist team-Medicinal chemist on serine protease inhibitor team-Medicinal chemist on Protein-Protein Interactions team-Leader of Bridgewater Science Education Outreach Committee
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Senior Research Associate, Medicinal Chemistry Department
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1996 - 1999
-Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of CNS diseases.-Chemistry project team co-leader for amyloid processing inhibitor team-Medicinal chemist for serotonin receptor antagonist team-Solid phase synthesis kinase inhibitor project (Selectide)-Member of Bridgewater Science Education Outreach Team -Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of CNS diseases.-Chemistry project team co-leader for amyloid processing inhibitor team-Medicinal chemist for serotonin receptor antagonist team-Solid phase synthesis kinase inhibitor project (Selectide)-Member of Bridgewater Science Education Outreach Team
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Associate Scientist, Medicinal Chemistry Department
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1993 - 1996
-Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of CNS diseases.-Medicinal chemist on dopamine receptor antagonist team-Medicinal chemist on acetylcholinesterase inhibitor team-Synthesized hydroxylated metabolites of Besipirdine HCl -Experience in design and execution of multi-step syntheses of complex organic molecules for the treatment of CNS diseases.-Medicinal chemist on dopamine receptor antagonist team-Medicinal chemist on acetylcholinesterase inhibitor team-Synthesized hydroxylated metabolites of Besipirdine HCl
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Education
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1988 - 1993
University of Maryland College Park
Ph.D, Organic Chemistry -
1986 - 1988
University of Illinois at Urbana-Champaign
MS, Organic Chemistry -
1982 - 1986
Penn State University
BS, Chemistry
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