Souvik Modi
Director of Research Development at Esya Labs- Claim this Profile
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Bio
Suruchi Sharma, PhD
Souvik was my senior during my PhD at Yamuna Krishan's Laboratory, we worked in the same group for five years. My initial training in the laboratory started by working with him, and I feel very fortunate for that. Souvik has an extraordinary capability to see what is important in a given scientific technique or equipment that made it possible to for him to establlish multiple new assays and new equipment in the laboratory in a very short duration of time. Wherever Souvik has worked, he has produced good quality work that speaks for his strength as a scientist. Souvik is a rare person who has good ideas as well as energy and the ability to execute them successfully. Souvik can scare away all the challenges with a big laughter. I never have to think even for a second to tell him anything; he has always been able to see beyond my words and never got offended. I wish him all the best always.
Suruchi Sharma, PhD
Souvik was my senior during my PhD at Yamuna Krishan's Laboratory, we worked in the same group for five years. My initial training in the laboratory started by working with him, and I feel very fortunate for that. Souvik has an extraordinary capability to see what is important in a given scientific technique or equipment that made it possible to for him to establlish multiple new assays and new equipment in the laboratory in a very short duration of time. Wherever Souvik has worked, he has produced good quality work that speaks for his strength as a scientist. Souvik is a rare person who has good ideas as well as energy and the ability to execute them successfully. Souvik can scare away all the challenges with a big laughter. I never have to think even for a second to tell him anything; he has always been able to see beyond my words and never got offended. I wish him all the best always.
Suruchi Sharma, PhD
Souvik was my senior during my PhD at Yamuna Krishan's Laboratory, we worked in the same group for five years. My initial training in the laboratory started by working with him, and I feel very fortunate for that. Souvik has an extraordinary capability to see what is important in a given scientific technique or equipment that made it possible to for him to establlish multiple new assays and new equipment in the laboratory in a very short duration of time. Wherever Souvik has worked, he has produced good quality work that speaks for his strength as a scientist. Souvik is a rare person who has good ideas as well as energy and the ability to execute them successfully. Souvik can scare away all the challenges with a big laughter. I never have to think even for a second to tell him anything; he has always been able to see beyond my words and never got offended. I wish him all the best always.
Suruchi Sharma, PhD
Souvik was my senior during my PhD at Yamuna Krishan's Laboratory, we worked in the same group for five years. My initial training in the laboratory started by working with him, and I feel very fortunate for that. Souvik has an extraordinary capability to see what is important in a given scientific technique or equipment that made it possible to for him to establlish multiple new assays and new equipment in the laboratory in a very short duration of time. Wherever Souvik has worked, he has produced good quality work that speaks for his strength as a scientist. Souvik is a rare person who has good ideas as well as energy and the ability to execute them successfully. Souvik can scare away all the challenges with a big laughter. I never have to think even for a second to tell him anything; he has always been able to see beyond my words and never got offended. I wish him all the best always.
Experience
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Esya Labs
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Biotechnology Research
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1 - 100 Employee
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Director of Research Development
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Sep 2022 - Present
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Head of Product R&D
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Jan 2021 - Nov 2022
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Tata Institute of Fundamental Research
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Research Services
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200 - 300 Employee
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Visiting Post-Doctoral Fellow
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Mar 2017 - Jan 2021
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UCL
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300 - 400 Employee
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Research Associate
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Sep 2012 - Dec 2016
Using super-resolution microscopy, nanocluster formation by Miro proteins on mitochondrial membrane is demonstrated. Further, using genetic, biochemical and electron microscopic techniques, I conclude that Miro nanoclusters interact with MINOS proteins. Upon genetic knock out of both Miro proteins, cells showed altered cristae morphology and reduced ER-Mitochondria contact sites. Using super-resolution microscopy, nanocluster formation by Miro proteins on mitochondrial membrane is demonstrated. Further, using genetic, biochemical and electron microscopic techniques, I conclude that Miro nanoclusters interact with MINOS proteins. Upon genetic knock out of both Miro proteins, cells showed altered cristae morphology and reduced ER-Mitochondria contact sites.
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National Centre for Biological Sciences
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Bengaluru Area, India
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PHD
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Sep 2005 - Sep 2012
For my PhD work I transformed a structural motifs in DNA (the i-motif) into an in cellulo pH sensing DNA nanomachine called the I-switch. I showed the I-switch sensor performed as a high performance pH sensor in which I then used to characterise pH gradients in the endocytic pathway of Drosophila hemocytes and SR+ cells. As a part of my thesis, I also developed a DNA binding scFv using phage display screen and then creating a chimera of scFv and plasma membrane protein that in turn acts as an artificial receptor for DNA. My studies showed that two distinct DNA nanomachines can be used simultaneously to map pH gradients along two different but intersecting cellular entry pathways. The two nanomachines, which are molecularly programmed to enter cells via different pathways, can map pH changes within well-defined subcellular environments along both pathways inside the same cell. Show less
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Education
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2003 - 2005
Jadavpur University
Master of Science - MS, Organic Chemistry -
2000 - 2003
Jadavpur University, Kolkata, India (2000-2003)
Bachelor's degree, Chemistry
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