Experience

Rice University

• United States
• Higher Education
• 700 & Above Employee

• PHD Candidate

  • Oct 2019 - Present

  Advisor: Caroline Ajo-Franklin In Ajo-Franklin's lab, I am focusing on characterizing and engineering the extracellular electron transfer pathway in probiotic lactic acid bacteria and in microbial community. The long term goal of my project is to creat probiotic bioelectronic sensors to assist rapid drug monitoring and disease diagnosis in situ. Advisor: Caroline Ajo-Franklin In Ajo-Franklin's lab, I am focusing on characterizing and engineering the extracellular electron transfer pathway in probiotic lactic acid bacteria and in microbial community. The long term goal of my project is to creat probiotic bioelectronic sensors to assist rapid drug monitoring and disease diagnosis in situ.



Wuhan University

• China
• Higher Education
• 700 & Above Employee

• Undergraduate Researcher

  • Oct 2017 - Jun 2019

  Advisors: Ke Lan & Shuwen WuUndergraduate thesis: The interaction between viral 3D polymerase and host cells during EV71 infectionScreen interacted proteins with Enterovirus 71 3D polymerase by IP-MS• Overexpressed 3D-Flag fusion protein in 293T under the infection background of EV71 & immunoprecipitated the 3D-Flag protein by anti-flag beads• Proteomics analysis and dissected the protein interaction patterns• Studied the interaction between ANXA2 and 3D polymerase with cell biology methods assisted by co-IP, CRISPR-Cas9, lentivirus integration, and immunofluorescence. High-throughput screens and studies of Enterovirus 71 sensitivity and resistance to inhibitors• Screened four thousand drugs & discovered four potent drugs against EV71• Performed time-course experiments to understand the mechanism of action of the drugs• Measured EC50 and CC50 of the drugs by qPCR and MTT assay, respectively• Screened drug-resistant strains of EV71 & performed whole-genome sequencing to find the mutated sites• Conducted mice experiments to test the drug potency in vivo Show less

• Research Assistant

  • Oct 2016 - Nov 2017

  Advisor: Hui SunEstablishment of a novel model for Autoimmune Hepatitis (AIH) & Study of the mechanism by which AAL induces AIH-like Hepatitis • Purified AAL protein from mushroom extraction• Tested the toxicity of AAL to liver• Isolated immunocytes & performed flow cytometry• Confirmed hepatitis by immunohistochemistry staining• Studied the potential mechanism of AAL induced AIH-like hepatitis



Wuhan Institute of Physics and Mathematics, CAS

• Wuhan, Hubei, China

• Research Assistant

  • Feb 2016 - May 2016

  Brain-wide tracing of neuron signal using mouse model • Performed recombinant RV (rabies virus) injection & cardiac perfusion & mouse cerebrum separation • Performed frozen section of mouse cerebrum • Analyzed fluorescent signal of neuron by fluorescence microscope Brain-wide tracing of neuron signal using mouse model • Performed recombinant RV (rabies virus) injection & cardiac perfusion & mouse cerebrum separation • Performed frozen section of mouse cerebrum • Analyzed fluorescent signal of neuron by fluorescence microscope