Experience

Korro Bio, Inc.

• United States
• Biotechnology Research
• 1 - 100 Employee

• Director, Head of HTS

  • Feb 2023 - Present



Exo Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Director, Discovery Biology

  • Jul 2022 - Jan 2023

  • Project lead for a hit-to-lead stage oncology preclinical project • Key member in lab building and department building • Key contributor for early target evaluation. • Project lead for a hit-to-lead stage oncology preclinical project • Key member in lab building and department building • Key contributor for early target evaluation.



Syros Pharmaceuticals

• United States
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Associate Director

  • Jun 2021 - Jul 2022

  Project lead for oncology preclinical project targeting CDK12, lead a multidisciplinary team with different backgrounds and priorities, set timelines and decision points, form feasible plans and drive execution. Served as the project manager until IND enabling phase. Successfully advanced program from target validation to DC nomination.Biology lead for 2nd Gen-CDK7i program that advanced SY-5609 into the clinic, primarily focused on assay development, MOA investigation, PK/PD development, biomarker in vitro and in vivo investigation, and combination strategy development. Authored in vitro and in vivo pharmacology IND study reports and assisted post-DC biomarker and indication evaluation.Key contributor for 1st gen-CDK7i program that advanced SY-1365 into the clinic, primarily focused on MOA investigation, PK/PD development, biomarker, and combination strategy development.Designed, managed and analyzed in vivo pharmacology studies for CDK7 and CDK12 programs in relevant CDX and PDX models based on genomic data to evaluate various biomarker hypotheses.Leading scientist in understanding MOA of CDK7 and CDK12 in relevant models, identified downstream markers faithfully reflect functions of the targets, developed assays to evaluate exposure dependent changes of markers in in vitro and in vivo samples to build PK/PD/efficacy relationship of the molecules.Key contributor in multiple preclinical programs for rare genetic diseases. Assisted building novel cellular assays for compound screenings and contributed to compound triage and go/no go decision. Key member in department building, help identify gaps in capabilities within department and form actionable plans to fill the gaps.Regularly work with business development, legal, finance and accounting for in-license evaluation, out-license preparation and presentation, patent filing, budgeting, and project management. Extensive experience managing international and domestic CROs for in vitro and in vivo work. Show less

• Principal Scientist

  • Feb 2020 - Jul 2021

• Senior Scientist

  • Feb 2018 - Feb 2020

• Scientist

  • Jul 2015 - Feb 2018



Geisel School of Medicine at Dartmouth

• Geisel School of Medicine at Dartmouth

• Research Assistant

  • Aug 2010 - Jul 2015

  • Studied mechanisms of CDK2 inhibition in lung cancers in vitro and in clinical samples, discovered a critical mediator centrosome protein 110 (CP110) and detailed mechanisms through which anaphase catastrophe was induced by CDK2 inhibition in lung cancer and mechanisms underlying high sensitivity of lung cancers with activated KRAS mutations towards anaphase catastrophe. • Planned, executed, and analyzed primary research and literature reviews in the field of lung cancer pharmacology, including clinical specimens and clinical trial outcomes in large and small data sets, and authored peer-reviewed publications. • Collaborated with peers, superiors, and local and extramural scientists in a team setting to improve workflow, implement new ideas, and develop national and international partnerships for deadline-driven research execution. • Highly proficient in various molecular biology and pharmacology techniques and data analysis tools. Show less



institute of neurology at Fudan University

• Shanghai City, China

• Research Assistant

  • Jun 2008 - Jun 2010

  Investigated the role of anterior cingulate cortex in “Doing more and getting more” task performance in rats by applying behavior neurobiology techniques and data analysis tools including Sigmaplot, MINITAB Investigated the role of anterior cingulate cortex in “Doing more and getting more” task performance in rats by applying behavior neurobiology techniques and data analysis tools including Sigmaplot, MINITAB