Serah Kimani, PhD

Research And Development Scientist at The Structural Genomics Consortium (SGC)
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Contact Information
us****@****om
(386) 825-5501
Location
Toronto, Ontario, Canada, CA

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Bio

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Credentials

  • Translating research to healthcare policy
    University of Michigan
    Jan, 2023
    - Oct, 2024
  • An introduction to global health
    Københavns Universitet - University of Copenhagen
    Apr, 2016
    - Oct, 2024
  • Introduction to Laboratory Animal Science
    University of Cape Town
    Nov, 2014
    - Oct, 2024
  • Introduction to Project Management
    University of Cape Town
    Jun, 2009
    - Oct, 2024

Experience

  • The Structural Genomics Consortium (SGC)
    • Canada
    • Research Services
    • 1 - 100 Employee
    • Research And Development Scientist
      • Jun 2023 - Present
  • Princess Margaret Cancer Centre
    • Canada
    • Medical Practices
    • 400 - 500 Employee
    • Research And Development Scientist
      • Jun 2019 - May 2023

      Based at the Structural Genomics Consortium (a biotech research institute) in Toronto, I worked on collaborative projects involving pharma partners and other stakeholders - carrying out biochemical, biophysical and structural studies of human proteins of therapeutic relevance to cancer and other disorders. In this role, I: • Designed expression constructs, expressed, and purified proteins for structural and biophysical studies • Performed protein crystallization and solved crystal structures of protein-ligand complexes to inform ligand development efforts • Employed various biophysical methods to probe binding of proteins to small molecules/peptides • Managed all research project activities • Wrote scientific papers for publication, research reports and summaries • Regularly attended and presented scientific findings to collaborators, group members and other stakeholders • Trained and guided students and new researchers My work resulted a number of potent targeted compounds characterized and a growing number of scientific papers. Show less

  • University of Cape Town
    • South Africa
    • Higher Education
    • 700 & Above Employee
    • Research Consultant and Assistant
      • Aug 2017 - Apr 2019

      I worked as a consultant and assistant to the head of the Structural Biology Research Unit (Prof. Trevor Sewell) • Supervised students and conducted specialized training and workshops in macromolecular X-ray crystallography • Conducted biochemistry and structural biology research on the nitrilase superfamily enzymes • Wrote scientific journals for publication • Prepared documentation for registration of the facility with various certification bodies I worked as a consultant and assistant to the head of the Structural Biology Research Unit (Prof. Trevor Sewell) • Supervised students and conducted specialized training and workshops in macromolecular X-ray crystallography • Conducted biochemistry and structural biology research on the nitrilase superfamily enzymes • Wrote scientific journals for publication • Prepared documentation for registration of the facility with various certification bodies

    • Research Fellow
      • Feb 2014 - Mar 2017

      I was involved in collaborative research aimed at identifying compounds targeting the oncogenic transcription factor from the human T-box family, TBX2, as well as screening and characterizing synthetic compounds for anti-cancer activity.• Performed cloning, expression and purification of the human TBX2 T-box protein for functional chromatographic compound screening and structural studies• Performed phenotypic screening and molecular characterization of synthetic anti-cancer compounds • Carried out in vivo toxicity and anti-tumor studies of anti-cancer compounds in animal models• Co-supervised and trained graduate students and early career scientists • Lectured graduate students• Prepared research grant applications • Tutored and demonstrated undergraduate and postgraduate experiments• Prepared documentation for animal ethics clearance• Wrote scientific manuscripts for publication• Managed mine and my students’ research activities• Regularly presented research findings to collaborators, group members, faculty research days and international conferencesMy work in this position led to 4 anti-cancer lead compounds characterized, all of which are published, and one of the them patented.Awards: Received 2 conference presentation awards, 1 conference travel grant & 2 research fellowships Show less

    • Research Assistant
      • Feb 2008 - Jan 2014

      This position largely covered my graduate studies where I investigated substrate specificity and the mechanism of action of amidases of medical and biotechnological importance using molecular biology, protein biochemistry, biophysical assays, structural biology and computational methods.Other duties included project management, supervision of undergraduate students, reporting of research findings, among others.This project lead to the definition of the of roles of four catalytic residues, as well as the determinants of substrate specificity in the nitrilase superfamily amidases.Awards: Received 4 scholarships, 3 travel grants, 7 conference presentation awards, 2 research fellowships and 4 recognition awards. Show less

Education

  • University of Cape Town
    Doctor of Philosophy (Ph.D.), Structural Biology
  • The University of British Columbia
    Graduate exchange program, Structure-based drug design
  • University of Cape Town
    Master's Degree, Structural Biology
  • Egerton University
    Bachelor's Degree, Biomedical Sciences and Technology

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