Saswata Sahoo (PhD)

Senior Chemist at Ceres Nanosciences, Inc.
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Contact Information
us****@****om
(386) 825-5501
Location
Burke, Virginia, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Senior Chemist
      • Apr 2021 - Present

      Manassas, Virginia, United States

    • Research Scientist
      • Jan 2019 - Mar 2021

      Manassas, Virginia - Design and synthesis of hydrogel-based nano-particles for clinical detection of diseases: cancer, bacteria and virus. - Employing a multi-disciplinary approach encompassing chemistry, biochemistry, microbiology and molecular biology to develop a complete workflow of harvesting PCR-quality DNA from patient samples for efficient Next Gen Sequencing in disease detection. - Scaled up manufacturing of virus-capturing particles utilized for enhanced detection of… Show more - Design and synthesis of hydrogel-based nano-particles for clinical detection of diseases: cancer, bacteria and virus. - Employing a multi-disciplinary approach encompassing chemistry, biochemistry, microbiology and molecular biology to develop a complete workflow of harvesting PCR-quality DNA from patient samples for efficient Next Gen Sequencing in disease detection. - Scaled up manufacturing of virus-capturing particles utilized for enhanced detection of COVID-19 infection.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Adjunct Faculty
      • Jun 2018 - Aug 2018

      Manassas, Virginia, USA ● Lecturing in General Chemistry. ● Laboratory instructor in General Chemistry.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Doctoral Researcher
      • Aug 2010 - May 2018

      United States ● Highly independent and limitedly supervised research focused on development of peptide drug for anti-microbial and anti-cancer therapeutic purposes in collaboration with 1 cross-disciplinary research faculty. ● Rational Design of Antimicrobial Peptide-drugs resulting in 3+ patentable lead compounds: i. Identification of bacteria and cancer/tumor cell-membrane disrupting structural motifs in peptide drug candidates after extensive literature mining involving linear and… Show more ● Highly independent and limitedly supervised research focused on development of peptide drug for anti-microbial and anti-cancer therapeutic purposes in collaboration with 1 cross-disciplinary research faculty. ● Rational Design of Antimicrobial Peptide-drugs resulting in 3+ patentable lead compounds: i. Identification of bacteria and cancer/tumor cell-membrane disrupting structural motifs in peptide drug candidates after extensive literature mining involving linear and macrocyclic molecules. ii. Finding amino acid sequence characteristics essential for Endo-toxin binding and Selective cancer-cell targeting by the peptides. iii. Selective sequence substitution for enhancing selective bacterial and cancer/tumor cell-membrane activities in the peptide- drug candidates. ● Developed High-Throughput cell-survival assay to bring uniformity, speed and reproducibility in evaluating the peptide-molecules against multiple bacterial strains. ● Modification of peptide by selective esterification producing 1 antimicrobial peptide-lipid conjugate. ● Assisted fellow PhD researcher in successful development of 3+ small-molecule drug inhibitors against caspases associated with auto-immune and Alzheimer’s diseases. Conducted liquid-chromatographic purification of the compounds and evaluated the inhibitory effects on enzyme kinetics.

    • Graduate Teaching Assistant
      • Aug 2011 - Dec 2017

      Virginia, USA ● Laboratory instructor for undergrad students in General Chemistry, Organic chemistry and Biochemistry. ● Train undergrad students in practical laboratory chemistry and techniques such as setting up experiments, titrations, organic synthesis, purification, identification and validation, organic spectroscopy (IR, NMR). ● Improvise course lessons and design experiments to supplement the theoretical understanding of chemistry in students. ● Grade students’ lab-reports, prepare… Show more ● Laboratory instructor for undergrad students in General Chemistry, Organic chemistry and Biochemistry. ● Train undergrad students in practical laboratory chemistry and techniques such as setting up experiments, titrations, organic synthesis, purification, identification and validation, organic spectroscopy (IR, NMR). ● Improvise course lessons and design experiments to supplement the theoretical understanding of chemistry in students. ● Grade students’ lab-reports, prepare daily quiz to assess students’ understanding and preparedness and conduct final exams. ● Lecturing in Chemistry and addressing student queries.

    • Trainee (Molecular Virology)
      • Dec 2008 - Jun 2009

      Kolkata, India ● Assisted senior PhD students in Molecular Biology. ● Received extensive experience in DNA and RNA purification, reverse transcription, PCR, Cloning and Expression of Recombinant Protein in bacteria. ● Conducted protein purification (utilizing AKTA purifier), Gel Electrophoresis and Western Blot. ● Received acknowledgement [Virology 2010 Vol. 407 (1): 33-42].

    • India
    • Research
    • 700 & Above Employee
    • Junior Research Chemist
      • Oct 2007 - Aug 2008

      Chembiotek, Kolkata Area, India ● Synthesis of heterocyclic drug candidates by modern synthetic organic chemistry methods including microwave assisted reactions, in Good Laboratory Practice (GLP) compliant environment. ● Purification of compounds by Liquid Chromatography, including Biotage Combiflash and preparative TLC.

    • Undergrad Researcher
      • Jun 2006 - May 2007

      Ballygunge Science College, Kolkata Area, India ● Studied toxicological stress related effects of gold nanoparticles on germination of jute seedlings. ● Evaluated kinetics of enzymes, such as peroxidases, and content of metabolites, such as vitamin C, utilizing combinations of UV-Visible Spectroscopy and titration methods.

Education

  • George Mason University
    Doctor of Philosophy (PhD), Chemistry and Biochemistry
    2010 - 2018
  • West Bengal University of Technology
    Bachelor of Technology (BTech), Biotechnology
    2003 - 2007

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