Sarsvat P.
Associate Director, Quantitative Pharmacology, Clinical Pharmacology & Toxicology at Repare Therapeutics- Claim this Profile
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Bio
Matthew Bahr
Sarsvat and I have worked together at GSK in pharmaceutical development for several years. Sarsvat has provided excellent mentorship to me in various aspects of modeling systems of bio-relevant significance. He draws on his years as a former University professor to coach and mentor with patience and compassion. During times where I struggled to understand some of the concepts, he always sought to define the terms in different ways to make sure I had a clear understanding. We have also collaborated on several research projects, where he partners easily with other team members and lends his expertise where needed.
Martin. Hingle
Sarsvat is a good biopharmaceutics scientist with significant expertise in Physiologically Based Pharmacokinetic (PBPK) modelling. Sarsvat works effectively across teams, projects, departments, and across divisions. He has a deep knowledge of solid-state characterization, solubility, dissolution, permeability, and a key contributor to industry-wide systems-based pharmaceutics alliance. These characteristics allow him to communicate modelling development and outcomes at a team, project, and all management levels effectively. He is dedicated, good at problem-solving, teamwork, and is an asset to any team. A diligent, committed, and trustworthy attitude, he is a pleasure to work with.
Matthew Bahr
Sarsvat and I have worked together at GSK in pharmaceutical development for several years. Sarsvat has provided excellent mentorship to me in various aspects of modeling systems of bio-relevant significance. He draws on his years as a former University professor to coach and mentor with patience and compassion. During times where I struggled to understand some of the concepts, he always sought to define the terms in different ways to make sure I had a clear understanding. We have also collaborated on several research projects, where he partners easily with other team members and lends his expertise where needed.
Martin. Hingle
Sarsvat is a good biopharmaceutics scientist with significant expertise in Physiologically Based Pharmacokinetic (PBPK) modelling. Sarsvat works effectively across teams, projects, departments, and across divisions. He has a deep knowledge of solid-state characterization, solubility, dissolution, permeability, and a key contributor to industry-wide systems-based pharmaceutics alliance. These characteristics allow him to communicate modelling development and outcomes at a team, project, and all management levels effectively. He is dedicated, good at problem-solving, teamwork, and is an asset to any team. A diligent, committed, and trustworthy attitude, he is a pleasure to work with.
Matthew Bahr
Sarsvat and I have worked together at GSK in pharmaceutical development for several years. Sarsvat has provided excellent mentorship to me in various aspects of modeling systems of bio-relevant significance. He draws on his years as a former University professor to coach and mentor with patience and compassion. During times where I struggled to understand some of the concepts, he always sought to define the terms in different ways to make sure I had a clear understanding. We have also collaborated on several research projects, where he partners easily with other team members and lends his expertise where needed.
Martin. Hingle
Sarsvat is a good biopharmaceutics scientist with significant expertise in Physiologically Based Pharmacokinetic (PBPK) modelling. Sarsvat works effectively across teams, projects, departments, and across divisions. He has a deep knowledge of solid-state characterization, solubility, dissolution, permeability, and a key contributor to industry-wide systems-based pharmaceutics alliance. These characteristics allow him to communicate modelling development and outcomes at a team, project, and all management levels effectively. He is dedicated, good at problem-solving, teamwork, and is an asset to any team. A diligent, committed, and trustworthy attitude, he is a pleasure to work with.
Matthew Bahr
Sarsvat and I have worked together at GSK in pharmaceutical development for several years. Sarsvat has provided excellent mentorship to me in various aspects of modeling systems of bio-relevant significance. He draws on his years as a former University professor to coach and mentor with patience and compassion. During times where I struggled to understand some of the concepts, he always sought to define the terms in different ways to make sure I had a clear understanding. We have also collaborated on several research projects, where he partners easily with other team members and lends his expertise where needed.
Martin. Hingle
Sarsvat is a good biopharmaceutics scientist with significant expertise in Physiologically Based Pharmacokinetic (PBPK) modelling. Sarsvat works effectively across teams, projects, departments, and across divisions. He has a deep knowledge of solid-state characterization, solubility, dissolution, permeability, and a key contributor to industry-wide systems-based pharmaceutics alliance. These characteristics allow him to communicate modelling development and outcomes at a team, project, and all management levels effectively. He is dedicated, good at problem-solving, teamwork, and is an asset to any team. A diligent, committed, and trustworthy attitude, he is a pleasure to work with.
Experience
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Repare Therapeutics
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Canada
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Biotechnology Research
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100 - 200 Employee
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Associate Director, Quantitative Pharmacology, Clinical Pharmacology & Toxicology
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Mar 2021 - Present
Quantitative Pharmacology, Clinical Pharmacology & Toxicology PBPK, PK-PD, popPK Modeling Quantitative Pharmacology, Clinical Pharmacology & Toxicology PBPK, PK-PD, popPK Modeling
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GSK
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United Kingdom
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Pharmaceutical Manufacturing
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700 & Above Employee
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Fellow, Biopharmaceutics and PBPK Modeling
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Aug 2019 - Mar 2021
Nominated and elected as Fellow by R&D council of Fellows (AF, F. SF). Role: Individual contributor, team member, and matrix team leaderResponsibilities: Visibility and credibility of the function and working across the functions to facilitate scientific discussions and exchange of data/information on compoundsADME characterization; PBPK modeling; and PK data analytics• Understanding and interpretation of permeability and transporter assays; in vitro assays for metabolic stability, biotransformation, enzyme inhibition/induction/phenotyping, and protein binding; in vitro-in vivo correlations for permeability, metabolism, and transport of drug candidates• Biorelevant solubility, Intrinsic dissolution rate, precipitation kinetics, biopharmaceutics project lead for discovery and clinical programs; Development of biopharmaceutics risk management strategy (discovery to development)• Building and verifying absorption and PBPK models; NCA analysis; Dose regimen selection/prediction; Product design for IR/MR oral formulations to meet PK/PD needs; Utilize modeling and simulations platforms to assess the structure-property-performance behavior of drug molecules
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Biopharmaceutics and PBPK Modeling Investigator
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Sep 2016 - Aug 2019
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Long Island University
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United States
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Higher Education
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700 & Above Employee
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Assistant Professor, College of Pharmacy
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Sep 2012 - Aug 2016
Mentoring and Teaching: M.S. and Ph.D. students in the areas of biopharmaceutics and modeling; Teaching courses on pharmacology/medicinal chemistry and pharmaceutics Research on structure-property-performance and biopharmaceutics of drugs: Developed a physicochemical property-based model to predict the human skin permeability of a Zwitterionic drug from a porcine skin permeability data; Developed mathematical models to predict the solubility of poorly soluble drugs in lipid-based solvent mixtures
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University of Minnesota
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United States
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Higher Education
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700 & Above Employee
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Postdoctoral Associate
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Apr 2010 - Aug 2012
• Process modeling; Development of a material-sparing technology platform to aid scalable tablet formulation of amorphous solid dispersions • Contract assignments for several pharmaceutical companies. • Process modeling; Development of a material-sparing technology platform to aid scalable tablet formulation of amorphous solid dispersions • Contract assignments for several pharmaceutical companies.
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National Institute of Pharmaceutical Education and Research
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Higher Education
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100 - 200 Employee
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DST Young Scientist
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Dec 2007 - Apr 2010
Bioavailability enhancement of a model BCS class IV drug; Process modeling and predictive models for mechanical properties developed and validated for binary and ternary mixtures involving poorly compressible drugs; Contract assignments for several pharmaceutical companies Bioavailability enhancement of a model BCS class IV drug; Process modeling and predictive models for mechanical properties developed and validated for binary and ternary mixtures involving poorly compressible drugs; Contract assignments for several pharmaceutical companies
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DBT
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Mexico
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IT Services and IT Consulting
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1 - 100 Employee
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Senior Research Fellow
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Jul 2006 - Dec 2007
Bioavailability enhancement of a model BCS class IV drug. - Achieved higher bioavailability through amorphous solid dispersion, self-microemulsifying drug delivery systems, micronized/nano suspension, cyclodextrin complex and spray-dried composites. Bioavailability enhancement of a model BCS class IV drug. - Achieved higher bioavailability through amorphous solid dispersion, self-microemulsifying drug delivery systems, micronized/nano suspension, cyclodextrin complex and spray-dried composites.
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Junior Research Fellow
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Jul 2004 - Jun 2006
• Mathematical modeling for compaction process • Contract assignments for several pharmaceutical companies • Mathematical modeling for compaction process • Contract assignments for several pharmaceutical companies
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Education
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University of Minnesota-Twin Cities
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2006 - 2010
National Institute of Pharmaceutical Education and Research
Ph.D., Pharmaceutics -
2004 - 2006
National Institute of Pharmaceutical Education and Research
M. Pharm., Pharmaceutical Technology, (Formulations) -
2000 - 2004
Hemchandracharya North Gujarat University
B. Pharm., Pharmaceutics, Pharmacology/Toxicology, Medicinal Chemistry, Pharmaceutical Analysis, Pharmacognosy
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