Sarah Olmstead, PhD

Research And Development Manager at Transcend Therapeutics
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Location
Philadelphia, Pennsylvania, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Research And Development Manager
      • Jul 2023 - Present

    • Senior Scientist
      • Jan 2022 - Aug 2023

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Principal Scientist
      • Mar 2021 - Jan 2022

      • Director of preclinical studies for lead drug candidate (regulatory T cell enhancing peptide) in amyotrophic lateral sclerosis (ALS). • Lead translational clinical T cell biomarker program in ALS; overseeing timeline adherence, biomarker measurement (flow cytometry), and data analysis/interpretation. • Scientific support for business development meetings with venture capital groups and external stakeholders. • Coordinated and executed two external collaborative projects involving… Show more • Director of preclinical studies for lead drug candidate (regulatory T cell enhancing peptide) in amyotrophic lateral sclerosis (ALS). • Lead translational clinical T cell biomarker program in ALS; overseeing timeline adherence, biomarker measurement (flow cytometry), and data analysis/interpretation. • Scientific support for business development meetings with venture capital groups and external stakeholders. • Coordinated and executed two external collaborative projects involving biomarker identification in Alzheimer’s disease and biomarker validation in asthma.

    • Scientist II
      • Jan 2020 - Mar 2021

      • Developed strategy for preclinical and clinical biomarker study in ALS. • Optimized and validated prospective biomarkers (via multi-color flow cytometry) as well as ex vivo functional assays. • Lead data analysis using traditional (logistic regression, ANOVA) statistical techniques in addition to machine learning (CART) and AI (SOM) techniques to bring together multi-parameter datasets in biomarker discovery for Parkinson’s disease. Defined a model with the ability to identify patients… Show more • Developed strategy for preclinical and clinical biomarker study in ALS. • Optimized and validated prospective biomarkers (via multi-color flow cytometry) as well as ex vivo functional assays. • Lead data analysis using traditional (logistic regression, ANOVA) statistical techniques in addition to machine learning (CART) and AI (SOM) techniques to bring together multi-parameter datasets in biomarker discovery for Parkinson’s disease. Defined a model with the ability to identify patients with 90% accuracy using a small dataset. • Prepared and presented data for internal meetings. • Acting as scientific support by preparing and reviewing presentations for external partners. • Mentored junior lab technicians. • Authored 4 grant applications in a variety of neurodegenerative topics, leveraging previously collected samples for genetic analysis.

    • Clinical Flow Cytometry Scientist I
      • Jun 2018 - Jan 2020

      • Executed clinical biomarker study in Parkinson’s disease (multi-color flow cytometry, LC/MS, ELISA). • Performed enzymatic assays. • Prepared and presented data for internal meetings. • Awarded a grant from the Department of Defense for investigation of lead compound in ALS. • Authored or assisted in authoring 3 additional grant applications.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Postdoctoral Research Fellow
      • Jun 2015 - Jun 2018

      • Initiated research and development for sleep fragmentation in neonates. • Lead a cross-departmental team investigating a lead drug candidate in protecting against cognitive decline following cardiac arrest. • Collaborated within the department to begin investigating sleep disturbances in Rett syndrome, ischemia, and traumatic brain injury. • Prepared and presented data for internal meetings, five society meetings and two local meetings. • Trained and supervised three undergraduate… Show more • Initiated research and development for sleep fragmentation in neonates. • Lead a cross-departmental team investigating a lead drug candidate in protecting against cognitive decline following cardiac arrest. • Collaborated within the department to begin investigating sleep disturbances in Rett syndrome, ischemia, and traumatic brain injury. • Prepared and presented data for internal meetings, five society meetings and two local meetings. • Trained and supervised three undergraduate students. Show less • Initiated research and development for sleep fragmentation in neonates. • Lead a cross-departmental team investigating a lead drug candidate in protecting against cognitive decline following cardiac arrest. • Collaborated within the department to begin investigating sleep disturbances in Rett syndrome, ischemia, and traumatic brain injury. • Prepared and presented data for internal meetings, five society meetings and two local meetings. • Trained and supervised three undergraduate… Show more • Initiated research and development for sleep fragmentation in neonates. • Lead a cross-departmental team investigating a lead drug candidate in protecting against cognitive decline following cardiac arrest. • Collaborated within the department to begin investigating sleep disturbances in Rett syndrome, ischemia, and traumatic brain injury. • Prepared and presented data for internal meetings, five society meetings and two local meetings. • Trained and supervised three undergraduate students. Show less

    • United States
    • Higher Education
    • 700 & Above Employee
    • Graduate Assistant
      • Aug 2009 - May 2015

      • Designed, conducted, and completed research on motivational dysregulation in HIV-1. • Moved a compound from in vitro cell culture to in vivo testing demonstrating the therapeutic potential of a naturally occurring isoflavone compound in mitigating synaptic and behavioral dysfunction. • Dissertation work contributed to an NIH grant examining the neurobiological mechanisms of apathy in HIV-1 associated neurocognitive disorders (HAND). • Teaching Assistant or Instructor of Record for 7… Show more • Designed, conducted, and completed research on motivational dysregulation in HIV-1. • Moved a compound from in vitro cell culture to in vivo testing demonstrating the therapeutic potential of a naturally occurring isoflavone compound in mitigating synaptic and behavioral dysfunction. • Dissertation work contributed to an NIH grant examining the neurobiological mechanisms of apathy in HIV-1 associated neurocognitive disorders (HAND). • Teaching Assistant or Instructor of Record for 7 semesters. Show less • Designed, conducted, and completed research on motivational dysregulation in HIV-1. • Moved a compound from in vitro cell culture to in vivo testing demonstrating the therapeutic potential of a naturally occurring isoflavone compound in mitigating synaptic and behavioral dysfunction. • Dissertation work contributed to an NIH grant examining the neurobiological mechanisms of apathy in HIV-1 associated neurocognitive disorders (HAND). • Teaching Assistant or Instructor of Record for 7… Show more • Designed, conducted, and completed research on motivational dysregulation in HIV-1. • Moved a compound from in vitro cell culture to in vivo testing demonstrating the therapeutic potential of a naturally occurring isoflavone compound in mitigating synaptic and behavioral dysfunction. • Dissertation work contributed to an NIH grant examining the neurobiological mechanisms of apathy in HIV-1 associated neurocognitive disorders (HAND). • Teaching Assistant or Instructor of Record for 7 semesters. Show less

Education

  • The Johns Hopkins University School of Medicine
    Post Doctoral Fellow, Neuroscience
    2015 - 2018
  • University of South Carolina
    Doctor of Philosophy (Ph.D.), Experimental Psychology/Behavioral Neuroscience
    2009 - 2015
  • Albright College
    Bachelor of Science (BS), Psychobiology
    2005 - 2009

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