API Catalogue Business Unit Leader

• Aug 2023 - Present

Deputy Manager Business Unit API Catalogue

• Jul 2022 - Jul 2023

Product Manager

• Jun 2020 - May 2022

• Monitor the global market landscape and competition for each product line • Implementation of the pricing strategies and identify pricing-related performance improvement opportunities; • Support in selecting future products for development • Coordinate the internal project development activities to exploit the business opportunity identified • Monitor the global market landscape and competition for each product line • Implementation of the pricing strategies and identify pricing-related performance improvement opportunities; • Support in selecting future products for development • Coordinate the internal project development activities to exploit the business opportunity identified

Research & Innovation Project Manager

• May 2017 - Jun 2020

• Project Management of early-stage project from the design of new non-infringing Route of Synthesis to Proof of Concept • Project planning of generic API development activity (Interaction with R&D, QA, QC, Supply chain, HSE, engineering) and Assistance to R&D team on scientific topic (i.e. impurity assessment and identification) • Coordination of Research Program involving multiple external partner (Academic and Industrial) • Business… Show more • Project Management of early-stage project from the design of new non-infringing Route of Synthesis to Proof of Concept • Project planning of generic API development activity (Interaction with R&D, QA, QC, Supply chain, HSE, engineering) and Assistance to R&D team on scientific topic (i.e. impurity assessment and identification) • Coordination of Research Program involving multiple external partner (Academic and Industrial) • Business Development related activities: Systematic evaluation of Request for Proposals and contribution to the preparation of the offer • Evaluation of the process by Unit Operation approach and extrapolation of data necessary to forecast R&D and production activities. • Participation to Commercial and technical audit • Strategic selection of the potential portfolio for new generic APIs from online resources and database with a scientific and market-oriented approach • Bibliographic research and preparation of preliminary written opinion on patent literature • Participation as invited speaker to Congress and Events Show less • Project Management of early-stage project from the design of new non-infringing Route of Synthesis to Proof of Concept • Project planning of generic API development activity (Interaction with R&D, QA, QC, Supply chain, HSE, engineering) and Assistance to R&D team on scientific topic (i.e. impurity assessment and identification) • Coordination of Research Program involving multiple external partner (Academic and Industrial) • Business… Show more • Project Management of early-stage project from the design of new non-infringing Route of Synthesis to Proof of Concept • Project planning of generic API development activity (Interaction with R&D, QA, QC, Supply chain, HSE, engineering) and Assistance to R&D team on scientific topic (i.e. impurity assessment and identification) • Coordination of Research Program involving multiple external partner (Academic and Industrial) • Business Development related activities: Systematic evaluation of Request for Proposals and contribution to the preparation of the offer • Evaluation of the process by Unit Operation approach and extrapolation of data necessary to forecast R&D and production activities. • Participation to Commercial and technical audit • Strategic selection of the potential portfolio for new generic APIs from online resources and database with a scientific and market-oriented approach • Bibliographic research and preparation of preliminary written opinion on patent literature • Participation as invited speaker to Congress and Events Show less

Researcher

• Feb 2014 - May 2017

Stereoselective synthesis of new unnatural amino acids, in particular unsaturated and silicon containing amino acids. Application of these new entities for the preparation of peptides and peptidomimetics possessing biological interest such as Neurotensin analogs for the treatment of neurophatic pain. Stereoselective synthesis of new unnatural amino acids, in particular unsaturated and silicon containing amino acids. Application of these new entities for the preparation of peptides and peptidomimetics possessing biological interest such as Neurotensin analogs for the treatment of neurophatic pain.

Research Associate

• Apr 2013 - Jan 2014

Development and scale-up of synthetic processes related to phospholipids. Development and scale-up of synthetic processes related to phospholipids.

Post-doc position in organic chemistry

• Apr 2011 - Mar 2013

Synthesis and biological evaluation of RGD integrin ligands containing a bifunctional diketopiperazine scaffold: Diketopiperazine scaffold was used to synthesise a cyclic peptidomimetic containing the arginine-glycine-aspartate (RGD) sequence These compounds were found to be good ligands for the integrin receptors. Their modulating properties on the angiogenetic process is under investigation on HUVEC cells. Design and synthesis of beta-hairpins based on a functionalized cis-DKP… Show more Synthesis and biological evaluation of RGD integrin ligands containing a bifunctional diketopiperazine scaffold: Diketopiperazine scaffold was used to synthesise a cyclic peptidomimetic containing the arginine-glycine-aspartate (RGD) sequence These compounds were found to be good ligands for the integrin receptors. Their modulating properties on the angiogenetic process is under investigation on HUVEC cells. Design and synthesis of beta-hairpins based on a functionalized cis-DKP scaffold as potential inhibitors of Abeta1-42 aggregation Preparation and use of secondary structure inducing elements with respect to the growing peptide and/or peptidomimetic chain that are able to establish a defined secondary structure with the biological target Abeta1-42 preventing its aggregation. Show less Synthesis and biological evaluation of RGD integrin ligands containing a bifunctional diketopiperazine scaffold: Diketopiperazine scaffold was used to synthesise a cyclic peptidomimetic containing the arginine-glycine-aspartate (RGD) sequence These compounds were found to be good ligands for the integrin receptors. Their modulating properties on the angiogenetic process is under investigation on HUVEC cells. Design and synthesis of beta-hairpins based on a functionalized cis-DKP… Show more Synthesis and biological evaluation of RGD integrin ligands containing a bifunctional diketopiperazine scaffold: Diketopiperazine scaffold was used to synthesise a cyclic peptidomimetic containing the arginine-glycine-aspartate (RGD) sequence These compounds were found to be good ligands for the integrin receptors. Their modulating properties on the angiogenetic process is under investigation on HUVEC cells. Design and synthesis of beta-hairpins based on a functionalized cis-DKP scaffold as potential inhibitors of Abeta1-42 aggregation Preparation and use of secondary structure inducing elements with respect to the growing peptide and/or peptidomimetic chain that are able to establish a defined secondary structure with the biological target Abeta1-42 preventing its aggregation. Show less

Internship

• Feb 2011 - Mar 2011

Development and accreditation of a method for the quantitative determination of Boldenone and Teobromine via GC/MS analysis in equine. Development and accreditation of a method for the quantitative determination of Boldenone and Teobromine via GC/MS analysis in equine.

Ph.D. student

• Oct 2007 - Dec 2010

Synthesis of constrained non natural amino acids and their use in the synthesis of peptidomimetics. Desing and synthesis of folding inhibitors of HIV-1 Protease: design and development of peptidomimetics and short peptides (p-LES) whose sequence are identical to fundamentals regions of the HIV-1 PR monomer, named local elementary structures (LES), responsible of the folding of the protease. Synthesis and study on the interaction between p-LES and the complementary LES that could prevent the… Show more Synthesis of constrained non natural amino acids and their use in the synthesis of peptidomimetics. Desing and synthesis of folding inhibitors of HIV-1 Protease: design and development of peptidomimetics and short peptides (p-LES) whose sequence are identical to fundamentals regions of the HIV-1 PR monomer, named local elementary structures (LES), responsible of the folding of the protease. Synthesis and study on the interaction between p-LES and the complementary LES that could prevent the entire folding process destibilizing the native conformation of HIV-1 protease. Synthesis of new non peptidic inhibitors of HIV-1 Protease dimerization: design and synthesis of mimetics of the terminal beta-sheet of the HIV-1 protease, which is responsible for the stabilization of the homodimeric protein. Compounds mimiking this region, able to interfere with the hydrogen bonds of the antiparallel beta-sheet between the two monomers, are used to replace one of the native monomer acting as a competitor. Show less Synthesis of constrained non natural amino acids and their use in the synthesis of peptidomimetics. Desing and synthesis of folding inhibitors of HIV-1 Protease: design and development of peptidomimetics and short peptides (p-LES) whose sequence are identical to fundamentals regions of the HIV-1 PR monomer, named local elementary structures (LES), responsible of the folding of the protease. Synthesis and study on the interaction between p-LES and the complementary LES that could prevent the… Show more Synthesis of constrained non natural amino acids and their use in the synthesis of peptidomimetics. Desing and synthesis of folding inhibitors of HIV-1 Protease: design and development of peptidomimetics and short peptides (p-LES) whose sequence are identical to fundamentals regions of the HIV-1 PR monomer, named local elementary structures (LES), responsible of the folding of the protease. Synthesis and study on the interaction between p-LES and the complementary LES that could prevent the entire folding process destibilizing the native conformation of HIV-1 protease. Synthesis of new non peptidic inhibitors of HIV-1 Protease dimerization: design and synthesis of mimetics of the terminal beta-sheet of the HIV-1 protease, which is responsible for the stabilization of the homodimeric protein. Compounds mimiking this region, able to interfere with the hydrogen bonds of the antiparallel beta-sheet between the two monomers, are used to replace one of the native monomer acting as a competitor. Show less

Ph.D. Student

• Oct 2008 - Aug 2009

Synthesis of new non peptidic inhibitors of HIV-1 Protease dimerization: design and synthesis of mimetics of the terminal beta-sheet of the HIV-1 protease, which is responsible for the stabilization of the homodimeric protein. Compounds mimiking this region, able to interfere with the hydrogen bonds of the antiparallel beta-sheet between the two monomers, are used to replace one of the native monomer acting as a competitor. Synthesis of new non peptidic inhibitors of HIV-1 Protease dimerization: design and synthesis of mimetics of the terminal beta-sheet of the HIV-1 protease, which is responsible for the stabilization of the homodimeric protein. Compounds mimiking this region, able to interfere with the hydrogen bonds of the antiparallel beta-sheet between the two monomers, are used to replace one of the native monomer acting as a competitor.

Pharm. D. Student

• Oct 2006 - Mar 2007

The main functional domain of the Id proteins is the helix-loop helix (HLH) motif, consisting of two amphipathic alpha-helices connected by a loop. The loop regions are important to determine the folding of a biomolecule and they can play a role in protein-ligand and protein-protein interactions. Starting from this observation, we were interested in the use of the unnatural amino acid Cpg as loop surrogate, which should preferably stabilize a parallel arrangement of the two flanking regions, as… Show more The main functional domain of the Id proteins is the helix-loop helix (HLH) motif, consisting of two amphipathic alpha-helices connected by a loop. The loop regions are important to determine the folding of a biomolecule and they can play a role in protein-ligand and protein-protein interactions. Starting from this observation, we were interested in the use of the unnatural amino acid Cpg as loop surrogate, which should preferably stabilize a parallel arrangement of the two flanking regions, as it is suggested that the HLH motif of the Id proteins also displays a parallel helix packing, at least as heterodimer subunit. I have obtained a series of compounds using the enantiopure Cpg derivatives as N,N-linkage of two peptide fragments, previously synthesized by automated stepwise solid phase synthesis with the Fmoc strategy. The effect of both enantiomers of the Cpg on the conformation has been investigated by CD spectroscopy, as well as their ability to interact with the native Id1 HLH motif. It was found that the Cpg-linked peptides containing the Id1 helix2 fragment 91-101 could interact with the native Id1 HLH motif, leading to helix stabilization or destabilization of the latter depending on Cpg configuration. Show less The main functional domain of the Id proteins is the helix-loop helix (HLH) motif, consisting of two amphipathic alpha-helices connected by a loop. The loop regions are important to determine the folding of a biomolecule and they can play a role in protein-ligand and protein-protein interactions. Starting from this observation, we were interested in the use of the unnatural amino acid Cpg as loop surrogate, which should preferably stabilize a parallel arrangement of the two flanking regions, as… Show more The main functional domain of the Id proteins is the helix-loop helix (HLH) motif, consisting of two amphipathic alpha-helices connected by a loop. The loop regions are important to determine the folding of a biomolecule and they can play a role in protein-ligand and protein-protein interactions. Starting from this observation, we were interested in the use of the unnatural amino acid Cpg as loop surrogate, which should preferably stabilize a parallel arrangement of the two flanking regions, as it is suggested that the HLH motif of the Id proteins also displays a parallel helix packing, at least as heterodimer subunit. I have obtained a series of compounds using the enantiopure Cpg derivatives as N,N-linkage of two peptide fragments, previously synthesized by automated stepwise solid phase synthesis with the Fmoc strategy. The effect of both enantiomers of the Cpg on the conformation has been investigated by CD spectroscopy, as well as their ability to interact with the native Id1 HLH motif. It was found that the Cpg-linked peptides containing the Id1 helix2 fragment 91-101 could interact with the native Id1 HLH motif, leading to helix stabilization or destabilization of the latter depending on Cpg configuration. Show less