Experience

Patanjali Research Institute

• India
• Research Services
• 100 - 200 Employee

• Head- In vitro Biology

  • May 2021 - Present



University of Iowa

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral research fellow

  • Mar 2019 - Apr 2021

  Involved in a project to decipher the role of Pyruvate kinase M2 in macrophage polarization and development of atherosclerosis in mouse model Involved in a project to decipher the role of Pyruvate kinase M2 in macrophage polarization and development of atherosclerosis in mouse model



University of Missouri-Columbia

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Fellow

  • May 2017 - Feb 2019

  • Investigated the protective effects of a pharmacological inhibitor (DAPT) of Notch signaling in an established abdominal aortic aneurysm using an Angiotensin-II induced mouse model• Evaluate the effects of myeloid-specific inducible-Notch1 haploinsufficiency on aneurysm progression • Investigated the protective effects of a pharmacological inhibitor (DAPT) of Notch signaling in an established abdominal aortic aneurysm using an Angiotensin-II induced mouse model• Evaluate the effects of myeloid-specific inducible-Notch1 haploinsufficiency on aneurysm progression



Daiichi Sankyo, Inc.

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Group Leader

  • Apr 2015 - Jan 2017

  • Worked as a project leader on several in-house drug discovery projects (TA: Auto-immune disorders & Asthma/COPD) with the primary objective of leading the project forward and meeting all project deliverables, including primary and secondary assays for establishment of structure-activity relationship (SAR)• Successfully coordinated with chemistry, DMPK and in-vivo teams nationally and internationally to discuss the progress and outline the way forward• Efficiently conducted IND studies and documented the study results• Introduced and incorporated new technologies into the pre-clinical drug discovery process• Mentored and supervised young scientists/researchers



Daiichi Sankyo

• Pharmaceutical Manufacturing
• 400 - 500 Employee

• Senior Researcher

  • Apr 2014 - Mar 2015

  • Acted as interface between various project teams working at R&D centers of Tokyo (Japan) and India• Developed internal collaborations to generate research tools and data• Lead scientific discussions to monitor project milestones and other requirements• Involved in hit to lead optimization of the target for autoimmune disorder (systemic lupus erythematous)• Standardized assays to show the downstream signaling of the target receptors using isolated human pDCs and B cells • Acted as interface between various project teams working at R&D centers of Tokyo (Japan) and India• Developed internal collaborations to generate research tools and data• Lead scientific discussions to monitor project milestones and other requirements• Involved in hit to lead optimization of the target for autoimmune disorder (systemic lupus erythematous)• Standardized assays to show the downstream signaling of the target receptors using isolated human pDCs and B cells



Daiichi Sankyo, Inc.

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Group Leader

  • Jul 2011 - Mar 2014

  • Lead a team with the responsibility of target identification and evaluation, (TA: Respiratory & Inflammation and Autoimmune disorders) designing and overseeing in vitro and ex vivo studies while applying relevant concepts, techniques and technologies to meet project deliverables• Developed various primary enzymatic and cell-based GPCR assays, selectivity assays and mechanistic assays for different programs in a 96 and 384 well format• Managed the development and miniaturization of biochemical and cell-based assays for High Throughput Screening (HTS)• Monitored the progress of junior scientists and continuously provided guidance for their overall development

• Senior Research Scientist

  • Jul 2010 - Jun 2011

  • Proactively involved in enzymatic and cell-based profiling of New Chemical Entities for various targets (TA: Oncology and inflammation)• Played a key role in setting up of in vitro DMPK lab. Optimized various assays (Cyp, Clint, PPB, ERM etc.) for routine screening of short-listed compounds of all the ongoing programs using TECAN liquid handler• Development of a variety of assays and execution of activity screens. Preparation of guidelines and SOPs



Ranbaxy

• India
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Senior Research Scientist

  • Jan 2009 - Jun 2010

  • Responsible for the development of in vitro and cell-based assays for various kinase inhibitor programs and different targets of arachidonic acid pathway• Hands-on experience of setting up in vitro assays for inflammation and Oncology disease area for the first in class and best in class drug targets• Effectively performed ex-vivo sample analysis using the modern molecular and biochemical tools and in vitro screening of anti-inflammatory new chemical entities

• Research Scientist

  • Dec 2006 - Dec 2008

  • Skillfully worked in Ranbaxy-GSK Collaborative Drug Discovery Program for COPD: Attained milestone towards demonstration of pre-clinical PoC for matrix metalloprotease (MMPs) inhibitor program. Lead molecule progressed to and successfully cleared, Phase I studies• Development and validation of fluorescence based medium throughput assays for enzymes, lipid mediators and cytokines etc. to decipher the mechanism of action of small molecules for various drug targets for respiratory and Oncology disease areas• Involved in assay development and screening for biomarkers from samples of Phase I Clinical Trials of Ranbaxy’s candidate molecule for COPD



Panacea Biotec

• India
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Research Scientist

  • Jan 2006 - Nov 2006

  • Generated Peptide library from Biological sources involving extraction of total proteins• Isolated peptide fractions and further assessment for their biological activity using various in vitro assay systems.• Involved in setting-up of lab, procurement of instruments and making their SOPs • Generated Peptide library from Biological sources involving extraction of total proteins• Isolated peptide fractions and further assessment for their biological activity using various in vitro assay systems.• Involved in setting-up of lab, procurement of instruments and making their SOPs