Experience

Sanzyme P LTD

• India
• Pharmaceutical Manufacturing
• 100 - 200 Employee

• Senior Manager, Sanzyme (P) Ltd.

  • Aug 2018 - Present

  Experience in setting up both Process & Analytical R&D followed by Production Facility for Downstream Process and qualified the facility for both internal and external audits. Playing vital role on the Commercialization and launching of products (Product development, Optimization and Tech-transfer) Contributed for annual Budget/Capex, Project/resource planning and communicated effectively with various departments including Marketing, Regulatory and Supply Chain to achieve organization's goal. Provided the guidance and reviewed the CTD-related documents in accordance with the country specific regulatory requirements. Show less



Dr. Reddy’s Laboratories

• India
• Pharmaceutical Manufacturing
• 200 - 300 Employee

• Senior Scientist

  • Feb 2014 - Aug 2018

   Set-up a downstream department as a part of fermentation unit to handle isolation, purification and semi-synthesis of fermentation derived generic peptides.  Leading downsteam process development and characterization of fusion protein, peptides, small molecules including highly-selective non-infringing methods for the synthesis, purification and lyophilization of complex peptides, key intermediates etc.  Delivered both fermentation and synthetic-derived Generic Peptide having >98% purity by Pilot scale for Process characterization, Customers, Formulation & AR&D Developmental Studies.  Involved in the RM cost model for API, preparing reports for RCGM, USFDA Briefing Book, reviewing process flow diagram and protocol as a part of manufacturing support.  Technical documentations: Development reports, Process protocol, Batch processing record, Impurity profile, QbD summary report, RM cost model for API etc. as a part of technology transfer to Plant. Show less



Dr. Reddy's Laboratories

• Hyderabad Area, India

• Team Lead

  • Feb 2014 - Jan 2017

  Team Leader, Downstream Process Chemist  Process development using Design of Experiment (DoE) techniques with Design Expert software. QbD-based approach for finding the design space and control strategy for the process.  Identification, isolation, characterization and synthesis of impurities in active pharmaceutical ingredients using HPLC and LCMS.  Significantly contributed for the success of scale up on the synthesis, purification and lyophilization of API developmental batch by continuous monitoring, troubleshooting and cross functional coordination  Preparation of SOPs and their implementation, documentation, data analysis, compilation and monitored equipment downtime and implemented corrective action procedures.  Trained SOI as per the safety related aspects of DRL and handled all the safety related activities.  Also hands on experience on synthetic method development, multistep organic synthesis, structure-based small molecules, complex peptides, glycopeptides, peptidomimetics, natural and unnatural amino acids. Show less



Korea Basic Science Institute

• Cheongwon-gun, Chungcheongbuk-do, Korea

• Postdoctoral Researcher

  • Sep 2009 - Jan 2014

  Bio-NMR Research Division, Korea Basic Science Institute Structure-based design, establish strategy for synthesizing NCEs during hit identification, lead identification and lead optimization as per our US and Japan collaborative work to generate novel therapeutics peptide scaffolds such as linear, cyclic, and glcopeptidomimetics targeting protein-protein interaction site of cancer-inducing Protein Kinase. Design andand synthesis of novel heterocylic-derived compounds for anticancer and antibacterial drugs. Synthesis of non-proteogenic amino acids and their derivatives. Design and synthesis of peptide-conjugates for the targeted delivery system and bioimaging. Show less



Korea Advanced Institute of Science and Technology

• Yuseong-gu, Daejeon, Korea

• Postdoctoral Researcher

  • Sep 2007 - Aug 2009

  Organic and Medicinal Chemistry. • Multiple step asymmetric synthesis of Polyketides, Imidazole alkaloids, furanose systems etc. Work involves designing a novel synthetic route, accomplishing the synthesis and scaling up the same to gram quantities. Organic and Medicinal Chemistry. • Multiple step asymmetric synthesis of Polyketides, Imidazole alkaloids, furanose systems etc. Work involves designing a novel synthetic route, accomplishing the synthesis and scaling up the same to gram quantities.