Raquel Costa
PhD student in Molecular Biosciences at ITQB-UNL- Claim this Profile
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Portuguese Native or bilingual proficiency
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Inglish Full professional proficiency
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Bio
Credentials
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Professional Development Course
IMFAHEJan, 2023- Oct, 2024 -
14th International Meeting of the Portuguese Carbohydrate Group
Sociedade Portuguesa de QuímicaJan, 2023- Oct, 2024 -
Diamond - CCP4 Data Collection and Structure Solution Course
Diamond Light SourceJan, 2020- Oct, 2024 -
25th International Symposium on Glycoconjugates
IUPACJan, 2019- Oct, 2024 -
CCP4 study weekend 2019 "Integrated, rational Molecular Replacement"
CCP4Jan, 2019- Oct, 2024 -
FEBS Advanced Course: Biomolecules in Action II
DESYJan, 2019- Oct, 2024 -
International Summer School of Crystallography
DESYJan, 2019- Oct, 2024 -
V Meeting of Synchrotron Radiation Users from Portugal (ENURS)
ITQB-UNLJun, 2016- Oct, 2024 -
Mass Spectrometry and Carbohydrates
Mass Spectrometry Center and NEQ, University of AveiroMay, 2016- Oct, 2024 -
Think metabolic, think Congenital Disorders of Glycosylation (CDG)
Educational Program on CDGFeb, 2016- Oct, 2024
Experience
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PhD student in Molecular Biosciences
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Jan 2018 - Present
Project: Deciphering the human-microbiome glyco-code: an integrative approach to uncover protein-glycan interactions in the gut environment Elucidated how a human gut bacterium interacts with glycans present at mucosal surfaces by: • Solving the first 3D structure of Bacteroides thetaiotaomicron that interacts with mucin O-glycans • Solving 6 more structures of protein/protein-glycan complexes from B. thetaiotaomicron • Discovering the glycan ligands for 3 proteins from B. thetaiotaomicron • Explaining the atomic details of 3 protein-glycan interactions • Optimizing the production of recombinant proteins from B. thetaiotaomicron Show less
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Universidade Nova de Lisboa
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Portugal
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Higher Education
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1 - 100 Employee
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Research fellow @ GlycoLab - Functional Glycobiology & Macromolecular Crystallography
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Jan 2017 - Dec 2017
Project: An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition • Continue the work develop in my master thesis • Applied for PhD fellowships Project: An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition • Continue the work develop in my master thesis • Applied for PhD fellowships
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Master of Science - Student and Researcher
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Sep 2015 - Nov 2016
Project: Ligand discovery and structural-functional analysis of proteins involved in plant cell wall degradation • Attributed the ligand specificity of a LysM domain from Clostridium thermocellum for chitin oligosaccharides and performed biophysical assays for binding affinity assessment • Identified a family 62 carbohydrate-binding module from Ruminococcus flavefaciens as a pectin binding protein • Optimized the production of proteins from C. thermocellum and R. flavefaciens Project: Ligand discovery and structural-functional analysis of proteins involved in plant cell wall degradation • Attributed the ligand specificity of a LysM domain from Clostridium thermocellum for chitin oligosaccharides and performed biophysical assays for binding affinity assessment • Identified a family 62 carbohydrate-binding module from Ruminococcus flavefaciens as a pectin binding protein • Optimized the production of proteins from C. thermocellum and R. flavefaciens
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Bachelor of Science
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Jan 2013 - Jul 2013
Project: Produced biodiesel using biocatalysts and supercritical CO2 • By using wasting cooking oils as a feedstock, I optimized the reaction to produce biodiesel • Identified the most efficient enzyme for the reaction, by calculation of kinetic parameters • Worked with reactors and supercritical fluids Project: Produced biodiesel using biocatalysts and supercritical CO2 • By using wasting cooking oils as a feedstock, I optimized the reaction to produce biodiesel • Identified the most efficient enzyme for the reaction, by calculation of kinetic parameters • Worked with reactors and supercritical fluids
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Education
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Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa - FCT NOVA
Master's degree, Biochemistry -
Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa - FCT NOVA
Bachelor's degree, Biochemistry