Rachel Knopp
Scientist at Universal Cells- Claim this Profile
Click to upgrade to our gold package
for the full feature experience.
Topline Score
Bio
Experience
-
Universal Cells
-
United States
-
Biotechnology
-
1 - 100 Employee
-
Scientist
-
Nov 2022 - Present
Seattle, Washington, United States
-
-
-
University of Washington
-
United States
-
Higher Education
-
700 & Above Employee
-
Postdoctoral Scholar Fellow
-
Oct 2020 - Nov 2022
Seattle, Washington, United States My postdoctoral studies were in a blood-brain barrier research lab under the direction of Drs. William Banks and Michelle Erickson. I was a funded T32 Postdoctoral Trainee of the Biological Mechanisms of Healthy Aging (BMHA) Training Program through the NIA (2020-current). Techniques/Skills used: brain microvessel isolation, cryosectioning, immunohistochemistry, western blotting, immunofluorescence, mouse behavior assays (cognitive and physical), enzyme-linked immunosorbent assay, stem… Show more My postdoctoral studies were in a blood-brain barrier research lab under the direction of Drs. William Banks and Michelle Erickson. I was a funded T32 Postdoctoral Trainee of the Biological Mechanisms of Healthy Aging (BMHA) Training Program through the NIA (2020-current). Techniques/Skills used: brain microvessel isolation, cryosectioning, immunohistochemistry, western blotting, immunofluorescence, mouse behavior assays (cognitive and physical), enzyme-linked immunosorbent assay, stem cell culture and differentiation, reverse transcriptase polymerase chain reaction, drug formulation and dosing. Show less
-
-
-
Seattle Institute for Biomedical and Clinical Research
-
United States
-
Research Services
-
1 - 100 Employee
-
Postdoctoral Researcher
-
Sep 2020 - Nov 2022
Seattle, Washington, United States
-
-
-
University of Illinois at Chicago - Graduate College
-
United States
-
Higher Education
-
1 - 100 Employee
-
PhD Candidate and Graduate Research Assistant
-
Aug 2015 - Jul 2020
Chicago, Illinois, United States I received my Ph.D. from the Pharmaceutical Sciences Department while working in a drug-discovery core lab under the direction of Dr. Greg Thatcher. I was supported by the T32 Predoctoral Trainee of Alzheimer's disease and related dementias (ADRD) through the NIA (2018-2020) Dissertation entitled "Cysteine Proteases as Therapeutic Targets for Neurodegenerative Diseases" -Developed a pre-clinical pipeline for selective and nonselective calpain-1 inhibitors -Characterized a novel in… Show more I received my Ph.D. from the Pharmaceutical Sciences Department while working in a drug-discovery core lab under the direction of Dr. Greg Thatcher. I was supported by the T32 Predoctoral Trainee of Alzheimer's disease and related dementias (ADRD) through the NIA (2018-2020) Dissertation entitled "Cysteine Proteases as Therapeutic Targets for Neurodegenerative Diseases" -Developed a pre-clinical pipeline for selective and nonselective calpain-1 inhibitors -Characterized a novel in vivo mouse model (ALDH2-/-) with underlying oxidative stress and mild traumatic brain injury -Implemented blood-brain barrier (BBB) techniques to the lab, including isolation of primary brain endothelial cells and in vivo BBB permeability studies. -Mentored and trained two undergraduates and one postbac researcher Techniques/skills used: enzymatic screening and kinetics, cell culture, primary murine cell isolation, quantitative real time PCR, western blotting, immunofluorescence staining, luciferase assay, RNA isolation, mouse handling, in vivo traumatic brain injury, drug preparation and dosing, blood-brain barrier leakage assays, imaging analysis using ImageJ, and lab management/ordering. Show less
-
-
-
Eli Lilly and Company
-
United States
-
Pharmaceutical Manufacturing
-
700 & Above Employee
-
Intern - Neurodegeneration Clinical Team
-
Jun 2019 - Jun 2019
Indianapolis, Indiana Area -Summer internship shadowing the early clinical development neurodegeneration clinical team -Participated in meetings of current and prospective drug candidates or targeting strategies in preclinical development.
-
-
-
University of Illinois at Chicago
-
United States
-
Higher Education
-
1 - 100 Employee
-
Graduate Teaching Assistant
-
Aug 2015 - Dec 2017
- Graduate Courses Taught: Principles of Drug Action and Therapeutics VIII, Biomedicinal Chemistry, Fundamentals of Drug Action, Fundamentals of Drug Action II, Experimental III – IPPE - Responsibilities included: assisting with preparation for exams, synthesizing and grading weekly quizzes, proctoring lecture-based tests, mentoring/tutoring students at weekly office hour sessions, and technical support for distance learning.
-
-
Education
-
University of Illinois at Chicago - Graduate College
Doctor of Philosophy - PhD, Medicinal and Pharmaceutical Chemistry -
Willamette University
Bachelor of Arts - BA, Biochemistry