Experience

Shanghai Jiao Tong University School of Medicine

• China
• Hospitals and Health Care
• 1 - 100 Employee

• Principal Investigator

  • Oct 2017 - Present



University of California, Berkeley

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Fellow

  • Jul 2011 - Oct 2017

  Study the epigenetic mechanisms for gene regulation using the model organism Caenorhabditis elegans. Key Accomplishments: • Discovered a condensin-driven mechanism for remodeling chromosome topology. • Developed Fluorescent In Situ Hybridization (FISH) and live-imaging assays for quantitative analysis of chromosome structure in C.elegans at single-cell level. • Contributed to the generation of the first three-dimensional map of C.elegans genome conformation using genome-wide… Show more Study the epigenetic mechanisms for gene regulation using the model organism Caenorhabditis elegans. Key Accomplishments: • Discovered a condensin-driven mechanism for remodeling chromosome topology. • Developed Fluorescent In Situ Hybridization (FISH) and live-imaging assays for quantitative analysis of chromosome structure in C.elegans at single-cell level. • Contributed to the generation of the first three-dimensional map of C.elegans genome conformation using genome-wide chromosome conformation capture technique (HiC). • Discovered a novel, chromosome-specific regulator of histone H4 Lysine 20 monomethylation (H4K20me1) and confirmed its function by performing CRISPR/Cas9-mediated mutagenesis. • Spearheaded the development of a series of genome-editing approaches in C.elegans using CRISPR/Cas9 and TALENs. • Co-organized the Berkeley MCB Postdoc Lunch Club, a platform for improving the communication and facilitating the career development of postdocs, from 2013-2015. • Mentored two undergraduates on scientific research. Show less Study the epigenetic mechanisms for gene regulation using the model organism Caenorhabditis elegans. Key Accomplishments: • Discovered a condensin-driven mechanism for remodeling chromosome topology. • Developed Fluorescent In Situ Hybridization (FISH) and live-imaging assays for quantitative analysis of chromosome structure in C.elegans at single-cell level. • Contributed to the generation of the first three-dimensional map of C.elegans genome conformation using genome-wide… Show more Study the epigenetic mechanisms for gene regulation using the model organism Caenorhabditis elegans. Key Accomplishments: • Discovered a condensin-driven mechanism for remodeling chromosome topology. • Developed Fluorescent In Situ Hybridization (FISH) and live-imaging assays for quantitative analysis of chromosome structure in C.elegans at single-cell level. • Contributed to the generation of the first three-dimensional map of C.elegans genome conformation using genome-wide chromosome conformation capture technique (HiC). • Discovered a novel, chromosome-specific regulator of histone H4 Lysine 20 monomethylation (H4K20me1) and confirmed its function by performing CRISPR/Cas9-mediated mutagenesis. • Spearheaded the development of a series of genome-editing approaches in C.elegans using CRISPR/Cas9 and TALENs. • Co-organized the Berkeley MCB Postdoc Lunch Club, a platform for improving the communication and facilitating the career development of postdocs, from 2013-2015. • Mentored two undergraduates on scientific research. Show less



University of Illinois Urbana-Champaign

• United States
• Higher Education
• 700 & Above Employee

• Graduate Research Assistant

  • Sep 2004 - Apr 2011

  Study the roles of chromosome structure and nuclear organization in transcription in mammalian cells. Key Accomplishments: • Identified epigenetic mechanisms responsible for the nuclear positioning and gene regulation of human beta-globin locus. • Invented a novel strategy (BAC TG-EMBED) for long-term, copy-number-dependent and position-independent transgene expression by creating open chromatin structure in cultured cells. • Characterized the changes of chromatin structure… Show more Study the roles of chromosome structure and nuclear organization in transcription in mammalian cells. Key Accomplishments: • Identified epigenetic mechanisms responsible for the nuclear positioning and gene regulation of human beta-globin locus. • Invented a novel strategy (BAC TG-EMBED) for long-term, copy-number-dependent and position-independent transgene expression by creating open chromatin structure in cultured cells. • Characterized the changes of chromatin structure associated with lineage-specific gene activation during ES cell differentiation using advanced microscopy. • Developed methods for visualizing various aspects of chromatin organization in vivo using Bacterial Artificial Chromosome (BAC) transgene arrays. • Standardized the protocol for engineering BACs and YACs. • Mentored two undergraduate students and supervised one technician on their scientific research. Show less Study the roles of chromosome structure and nuclear organization in transcription in mammalian cells. Key Accomplishments: • Identified epigenetic mechanisms responsible for the nuclear positioning and gene regulation of human beta-globin locus. • Invented a novel strategy (BAC TG-EMBED) for long-term, copy-number-dependent and position-independent transgene expression by creating open chromatin structure in cultured cells. • Characterized the changes of chromatin structure… Show more Study the roles of chromosome structure and nuclear organization in transcription in mammalian cells. Key Accomplishments: • Identified epigenetic mechanisms responsible for the nuclear positioning and gene regulation of human beta-globin locus. • Invented a novel strategy (BAC TG-EMBED) for long-term, copy-number-dependent and position-independent transgene expression by creating open chromatin structure in cultured cells. • Characterized the changes of chromatin structure associated with lineage-specific gene activation during ES cell differentiation using advanced microscopy. • Developed methods for visualizing various aspects of chromatin organization in vivo using Bacterial Artificial Chromosome (BAC) transgene arrays. • Standardized the protocol for engineering BACs and YACs. • Mentored two undergraduate students and supervised one technician on their scientific research. Show less



University of Science and Technology of China

• China
• Research
• 700 & Above Employee

• Undergraduate Research Assistant

  • Jan 2002 - Jul 2003

  Study the structure-function relationships of important proteins using X-ray crystallography. Key Accomplishments: • Cloned, expressed and purified O-acetylhomoserine sulfhydrylase from Leptospir interrogans. • Cloned, expressed, purified and crystallized Human Bisphosphoglycerate Mutase (hBPGM) and carry out preliminary X-ray diffraction study. Study the structure-function relationships of important proteins using X-ray crystallography. Key Accomplishments: • Cloned, expressed and purified O-acetylhomoserine sulfhydrylase from Leptospir interrogans. • Cloned, expressed, purified and crystallized Human Bisphosphoglycerate Mutase (hBPGM) and carry out preliminary X-ray diffraction study.