Experience

IVIVA Medical Inc

• United States
• Biotechnology Research
• 1 - 100 Employee

• Research associate

  • Jun 2022 - Present



Cornell University

• United States
• Higher Education
• 700 & Above Employee

• Graduate Student Researcher

  • Sep 2021 - May 2022

  The project is sponsored by Hospital for Special Surgery (HSS), New York. Our aim is to design a hydrogel that can adhere to the Bone. Hydrogel should have mechanical properties similar to the cartilage and must be injectable. We are currently working on the adherence of hydrogel and performing mechanical testing. We are trying to make a hydrogel that can be injected into lesions using an 18-25 gauge syringe. The project is sponsored by Hospital for Special Surgery (HSS), New York. Our aim is to design a hydrogel that can adhere to the Bone. Hydrogel should have mechanical properties similar to the cartilage and must be injectable. We are currently working on the adherence of hydrogel and performing mechanical testing. We are trying to make a hydrogel that can be injected into lesions using an 18-25 gauge syringe.



Institut Jacques Monod

• France
• Research Services
• 1 - 100 Employee

• Research Intern

  • May 2019 - Nov 2019

  For my master’s thesis, I joined Dr. Benoit Ladoux lab at Institute Jacques Monod, Paris and worked on ‘Role cell adhesion and cell mechanics in epithelial cell extrusion'. I addressed a curiosity driven question related to the cellular extrusion from a monolayer. We observed extrusion events in E-cadh KO and wild type MDCK cell. We disrupted the cell substrate interaction by treatment with blebbistatin & Y27 , and observed the extrusion events in both the cell types. Performed convergence analysis to confirm there is inward movement of cell at the extrusion site which vanishes after the extrusion. We also analysed for nematic order of tissue and extrusion from +1/2 and -1/2 nematic defects. As cancer cells undergo EMT further experiments on heterogeneous culture of E-cadh KO and WT cells could give us further insight into extrusion of cancer cells. We used spinning disk microscope to check the cytoskeleton structure of extruding cell in live samples and confocal microscope for fixed samples. To record a greater number of extrusion events, BioStation was used and imaging was done at 10X. We analyzed cellular convergence at extrusion and nematic defect analysis was done using MATLAB and ImageJ.



Indian Institute of Technology, Bombay

• India
• Higher Education
• 700 & Above Employee

• Student Researcher

  • May 2018 - Apr 2019

  During my summer internship, 7th and 8th semester project in Prof. Abhijit Majumder’s lab at IIT Bombay, I was exploring the effect of HDAC inhibitor (sodium butyrate) on human mesenchymal stem cells (hMSCs) at different substrate stiffness. I checked the effect of sodium butyrate for osteogenic and adipogenic differentiation of the hMSCs at different substrate stiffnesses namely- 3kPa and 34kPa. PA gels coated with collagen IV were used as substrate. We studied the differentiation, proliferation and spread area of hMSCs under these conditions. I was quite enthusiastic about this project as it has potential therapeutic applications. Sodium butyrate can also be used to promote osteogenesis for developing tissue engineered bones. The better the understanding we have of cues/factors that determines the stem cell fate, the better we will be able to tweak it to get particular desired outcomes. Also, this advances our understanding of the fundamental process of stem cell differentiation. I was involved in experimental design and performed the experiments and analysis.