Experience

Jadavpur University

• Higher Education
• 700 & Above Employee

• PHD

  • Oct 2015 - Present

  Area of research in PhD : • Synthesis of metal complexes of 5-nitroimidazoles (Ornidazole and Tinidazole); determined their crystal structures and performed detailed characterisations involving the use of several instrumental techniques. • Studied the electrochemical behaviour of ornidazole and its metal complexes using cyclic voltammetry in different solvents. • Investigated the interaction of nitro-radical anion generated either on the 5-nitroinidazoles or on metal complexes of 5-nitroinidazoles with nucleic acid bases (that was followed with the help of HPLC) and on calf thymus DNA (that was followed using fluorescence spectroscopy using ethidium bromide). • Investigation on gamma radiation induced damage of nucleic acid bases or DNA in the absence or presence of sensitizer molecules (Ornidazole and its monomeric and dimeric complexes) to investigate the mechanism of damage. • Performed an enzyme assay using xanthine oxidase to realise the extent of formation of nitro radical anion by 5-nitroimidazoles and their metal complexes. • Performed DNA binding studies of 5-nitroimidazoles and their metal complexes that was monitored with the help of cyclic voltammetry. • Through a collaboration, performed biological assays for anti-bacterial, anti-amoebic activities of 5-nitroimidazoles and their metal complexes. • Experience in working with instruments and techniques like HPLC, cyclic voltammetry, Fluorescence spectrophotometer, single crystal X-ray diffraction, mass spectrometry, FT-IR spectrophotometer, UV-Vis spectrophotometer, thermo-gravimetric analysis. Show less