Experience

Wageningen Bioveterinary Research

• Netherlands
• Research Services
• 100 - 200 Employee

• Senior molecular virologist

  • Aug 1990 - Present

  Experience in molecular virology, in particular reverse genetics and molecular diagnostics aiming development of DIVA vaccines. In the past, development and use of reverse genetics for many different ssRNA viruses, like classical swine fever virus (CSFV), bovine viral diarrhea virus (BVDV), porcine respiratory and reproductive syndrome virus (PRRSV) regarding vaccine development. At present, using reverse genetics for vaccine development for dsRNA viruses with a segmented genome, such as bluetongue virus (BTV) and African horse sickness virus (AHSV). Project leader of "Viral Zoonosis and Vector-borne animal Diseases (VZVD)" focusing on development of ISO17025 accredited diagnostic tests. Project leader of several research projects addressing vaccine development against orbiviruses. Highly interested in the interactions of insect borne viruses with mammalian and insect cells. Our recent research has resulted in DIVA vaccines named Disabled Infectious Single Animal (DISA) vaccines for Bluetongue and African horse sicknes. (Co-)inventor of several patents, including novel knowledge based Disabled Infectious Single Animal (DISA) vaccines for Bluetongue and African Horse Sickness. Founder of the Network of Excellence "EPIZONE". Show less



North-West University

• Department of Biochemistry, Centre for Human Metabolomics, North-West University

• Extraordinary professor

  • Jul 2013 - Present

  Extraordinary professor for a period of six years. Interested in molecular virology of double-stranded RNA viruses with segmented genomes, like the orbiviruses bluetongue virus and African horsesickness virus, rotavirus, and other members of the family of Reoviridae. Special interest in vaccine development and the interplay between virus-host and virus-insect vector. Extraordinary professor for a period of six years. Interested in molecular virology of double-stranded RNA viruses with segmented genomes, like the orbiviruses bluetongue virus and African horsesickness virus, rotavirus, and other members of the family of Reoviridae. Special interest in vaccine development and the interplay between virus-host and virus-insect vector.



Leiden University

• Netherlands
• Higher Education
• 700 & Above Employee

• PhD student

  • May 1985 - May 1990

  Thesis "Transcription regulation by IHF in bacteriophage Mu", May 10, 1990. van Rijn, P.A., Goosen, N., and van de Putte, P. (1988). The Integration Host Factor of Escherichia coli regulates early- and repressor transcription of bacteriophage Mu by two different mechanisms. Nucleic Acids Res. 16, 4595-4605. van Rijn, P.A., Goosen, N., Turk, S.C.H.J., and van de Putte, P. (1989). Regulation of phage Mu repressor transcription by IHF depends on the level of the early transcription. Nucleic Acids Res. 17, 10203-10211. van Rijn, P.A., van de Putte, P., and Goosen, N. (1991). Analysis of the IHF binding site in the regulatory region of bacteriophage Mu. Nucleic Acids Res. 19, 2825-2834. Show less



Leiden University Medical Center

• Netherlands
• Hospitals and Health Care
• 700 & Above Employee

• Scientist

  • 1984 - 1985

  Research on the circadian rythm in enzymatic activity in the intestinal brushborder membrane of rats. Hekkens, W.T., van Rijn, P.A., Lukac Bajalo, J., Ungerer, R., and Rietveld, W.J. (1985). Influence of a dorsomedial hypothalamus lesion on the circadian changes in the enzyme development and activity of intestinal brushborder membranes in the rat. Chronobiol. Int. 2, 103-108. Hekkens, W.T., van Rijn, P.A., Lukac Bajalo, J., Ungerer, R., and Rietveld, W.J. (1985) The effect of lesions of the dorsomedian hypothalamic nucleus of the composition and activity of the brushborder enzymes of the small-intestine in the rat. Journal of interdisciplinary cycle research. 16(2), 133. Show less