Clinical Program Lead

• Apr 2022 - Present

Clinical Project Manager

• Oct 2019 - Apr 2022

Project Leader

• Aug 2022 - Present

AI for Sustainable Prevention of Autoimmunity in the Society is a VINNOVA-funded project https://www.asset.healthcare/ AI for Sustainable Prevention of Autoimmunity in the Society is a VINNOVA-funded project https://www.asset.healthcare/

Career Development

• Jan 2019 - Aug 2019

Changing the scope of my career from academy to industry was an exciting challenge that required not only a solid technical background but also perseverance and a defined strategy to develop additional competences. I have dedicated a few months to acquire additional competence within the life science industry through relevant courses as well as improving my knowledge of the Swedish language. Changing the scope of my career from academy to industry was an exciting challenge that required not only a solid technical background but also perseverance and a defined strategy to develop additional competences. I have dedicated a few months to acquire additional competence within the life science industry through relevant courses as well as improving my knowledge of the Swedish language.

Project Leader

• Jan 2013 - Dec 2018

The main objective of my research is to uncover the network of molecular machines responsible for protein and peptide degradation in mitochondria. Mitochondria are cellular structures that carry out many essential biochemical reactions. Work in the last 4 years allowed me and my colleagues to work out how mitochondria get rid of toxic peptides and simultaneously recycle protein building blocks. To achive our goals, I led a cross-disciplinary team from several Universities in Sweden, Poland and Australia.This work has been reported in several scientific journals, including Nature Chemical Biology, J. Mol. Biology, Mol. Plant and PNAS. https://www.nature.com/articles/nchembio.2227http://www.pnas.org/content/110/40/E3761.longThis degradation pathway is of particular importance in the progression of Alzheimer's disease disease. The protease hPreP (or PITRM1) is responsible for the clearing of the toxic amyloid-beta peptide in the human brain. I was part of a large group of scientists lead by the MRC Mitochondrial biology unit (Cambridge, UK) and the University hospital Bergen (Norway), that identified human mutations in PITRM1 related with neurogeneration. This work was recently reported in EMBO Mol. Medicine.http://embomolmed.embopress.org/content/8/3/176.longMy work has been supported by independent grants from Carl Tryggers Stiftelse, Lars Hiertas minne Stiftelse, Stiftelsen Sigurd och Elsa Goljes Minne, Helge Ax:Son Johnsons Stiftelse.

Post Doc

• Jan 2010 - Jan 2013

During my post-doctoral period in Prof. Elisabet Glaser's laboratory I studied how reacting oxygen species affect the activity of the hPreP/PITRM1 protease and how that process can impact the degradation of the toxic amyloid-beta peptide.Within this project I collaborated closely with Prof. Rodney Levine (NIH), a leading expert on protein oxidation. Our studies resulted in two publications in one of the leading journals reporting on protein oxidation, Free Radical Biology and Medicine:https://www.sciencedirect.com/science/article/pii/S0891584912011732?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S0891584914004079?via%3DihubThe work was partially supported by a post-doctoral grant from the Foundation for Science and Technology, FCT-Portugal

Consultant

• Dec 2017 - Jan 2018

Provided technical expertise on proteases in a project involving industrially relevant cyanobacteria. Provided technical expertise on proteases in a project involving industrially relevant cyanobacteria.

Visiting Scholar

• Nov 2016 - Apr 2017

I was a visiting Researcher in Prof. Jim Whelan's laboratory (Center for AgriBioscience, La Trobe University). The main objective of this visit was the analysis of next-generation mRNA sequencing data. Prof. Whelan is one of the world-leading experts in mRNA sequencing and has been a long-standing collaboration partner in several projects I manage. Funded by the Swedish Foundation for International Cooperation in Research and Higher Education (STINT) I was a visiting Researcher in Prof. Jim Whelan's laboratory (Center for AgriBioscience, La Trobe University). The main objective of this visit was the analysis of next-generation mRNA sequencing data. Prof. Whelan is one of the world-leading experts in mRNA sequencing and has been a long-standing collaboration partner in several projects I manage. Funded by the Swedish Foundation for International Cooperation in Research and Higher Education (STINT)

Visiting Scholar

• Oct 2015 - Dec 2015

I was a visiting researcher in Dr. Monika Murcha’s laboratory at the ARC center of excellence in Plant Energy Biology (UWA, Perth). This visit was part of a joint project to identify a t-RNA import receptor in mitochondria. This research has been published in on of the leading plant journal Plant Physiology. http://www.plantphysiol.org/content/172/4/2471.long Funded by the Swedish Foundation for International Cooperation in Research and Higher Education (STINT) I was a visiting researcher in Dr. Monika Murcha’s laboratory at the ARC center of excellence in Plant Energy Biology (UWA, Perth). This visit was part of a joint project to identify a t-RNA import receptor in mitochondria. This research has been published in on of the leading plant journal Plant Physiology. http://www.plantphysiol.org/content/172/4/2471.long Funded by the Swedish Foundation for International Cooperation in Research and Higher Education (STINT)

Research Associate

• Oct 2004 - Dec 2005

I was a research associate in the Molecular Neurobiology group led by Prof. Maria João Saraiva. During my time at the IBMC, I studied the molecular halmarks of perypheral transthyretin amyloidosis. Particularly, we were the first to suggest that ER stress and calcium flux could be related with TTR deposition in a ground-breaking work published in the Journal of Biological Chemistry: http://www.jbc.org/content/281/31/21998.long I was also involved in histological analysis of mouse models and testing of human samples.