Pao-Sheng Chang

Postdoctoral Researcher at Nuffield Department of Clinical Neurosciences, University of Oxford
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Contact Information
us****@****om
(386) 825-5501
Location
UK
Languages
  • Mandarin Native or bilingual proficiency
  • English Native or bilingual proficiency
  • Taiwanese Native or bilingual proficiency
  • German Limited working proficiency
  • Japanese Limited working proficiency
Skills

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Bio

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Credentials

  • R Tidyverse Reporting and Analytics for Excel Users
    Udemy
    Jul, 2022
    - Nov, 2024
  • Easy Excel Dashboards, Models, Visualizations & Power Query
    Udemy
    Sep, 2021
    - Nov, 2024
  • Platinum English Typing Certificate (76 wpm, 99.8% accuracy)
    Ratatype
    Jan, 2019
    - Nov, 2024
  • edX Verified Certificate - Introduction to R for Data Science
    edX
    Jan, 2017
    - Nov, 2024
  • Good Clinical Practice e-Learning
    NHS
    Nov, 2016
    - Nov, 2024
  • Design and Interpretation of Clinical Trials
    Coursera Course Certificates
    Jul, 2016
    - Nov, 2024
  • Synapses, Neurons and Brains
    Coursera Course Certificates
    Aug, 2015
    - Nov, 2024
  • Introduction to Clinical Neurology
    Coursera Verified Certificates
    Mar, 2015
    - Nov, 2024

Experience

  • Nuffield Department of Clinical Neurosciences, University of Oxford
    • United Kingdom
    • Higher Education
    • 1 - 100 Employee
    • Postdoctoral Researcher
      • Jan 2023 - Present

      Postdoctoral Researcher in Neuromusculoskeletal Health and Science Lab, Neural Injury GroupSupervised by A/Prof Annina Schmid and Dr. Alexander Davies, my postdoc research project is to investigate the neuroimmunological signatures and interactions in human focal nerve compression.The project is funded by Ono Pharmaceutical Co., Ltd.

    • Research Assistant
      • May 2022 - Dec 2022

      ✦ Prepared the experimental materials for the diagnostic lab in Oxford Autoimmune Neurology Group (OANG)✦ Responsible for performing routine live cell-based diagnostic assays for detecting autoantibodies to LGI1, CASPR2, NMDAR, GABAAR, AQP4 and MOG from patients with psychosis, NMOSD or MOGAD

    • DPhil Candidate
      • Oct 2018 - Dec 2022

      ✦ Fully funded by Oxford-Taiwan Graduate Scholarship✦ Experienced in molecular cloning, bacteria culture, DNA extraction, site-directed mutagenesis, cell culture, transfection, live cell-based antibody assays, the operation of multi-color flow cytometry and fluorescence microscopes✦ Succeeded at expressing soluble cytokines and intracellular onconeural antigens on the surface of HEK293T cells as the targets for tumor-associated autoantibodies detection

  • Mable | Neurolytic Healthcare
    • United States
    • Hospitals and Health Care
    • 1 - 100 Employee
    • Research Analyst
      • Apr 2019 - Apr 2020

      ✦ Meta-analysed the pharmacogenetic targets of migraine drugs ✦ Won a £100k start-up fund from Panacea Stars business competition ✦ Meta-analysed the pharmacogenetic targets of migraine drugs ✦ Won a £100k start-up fund from Panacea Stars business competition

  • Careers Service, University of Oxford
    • United Kingdom
    • Higher Education
    • 1 - 100 Employee
    • Strategy Research Consultant
      • Feb 2019 - May 2019

      ✦ Worked in a strategy consulting team for a London-based client (Ogenblik Ltd.) ✦ Performed business/market analysis to identify the target market for launching OliTool®, which assisted the children with special emotional needs ✦ Supported our client to secure a £120k Innovate UK grant ✦ Worked in a strategy consulting team for a London-based client (Ogenblik Ltd.) ✦ Performed business/market analysis to identify the target market for launching OliTool®, which assisted the children with special emotional needs ✦ Supported our client to secure a £120k Innovate UK grant

  • Academia Sinica, Taiwan
    • Taiwan
    • Higher Education
    • 700 & Above Employee
    • Research Assistant
      • Dec 2017 - Aug 2018

      ✦ Performed IHC and IIF to detect TDP-43 and Aβ in paraffin-embedded brain tissues from AD patients ✦ Analysed IHC and IIF images by ImageJ macro plugin to quantify the colocalization of TDP-43 and Aβ ✦ Prepared mice brain cryosections after hTDP-43 intracerebral injection ✦ Optimised western blots and RT-qPCRs to quantify the level of HSC70/HCP70 in mice brain lysate ✦ Performed IHC and IIF to detect TDP-43 and Aβ in paraffin-embedded brain tissues from AD patients ✦ Analysed IHC and IIF images by ImageJ macro plugin to quantify the colocalization of TDP-43 and Aβ ✦ Prepared mice brain cryosections after hTDP-43 intracerebral injection ✦ Optimised western blots and RT-qPCRs to quantify the level of HSC70/HCP70 in mice brain lysate

  • Charité - Universitätsmedizin Berlin
    • Germany
    • Hospitals and Health Care
    • 700 & Above Employee
    • Research Intern
      • Sep 2017 - Nov 2017

      ✦ Awarded a 2-month Travel Grant from Berlin School of Mind & Brain ✦ Analysed structural MRI data from the patients with anti-NMDAR encephalitis ✦ Quantified patients’ brain atrophy via FSL and FreeSurfer’s image segmentation tools ✦ Awarded a 2-month Travel Grant from Berlin School of Mind & Brain ✦ Analysed structural MRI data from the patients with anti-NMDAR encephalitis ✦ Quantified patients’ brain atrophy via FSL and FreeSurfer’s image segmentation tools

  • UCL
    • United Kingdom
    • Research Services
    • 700 & Above Employee
    • Research Student
      • Nov 2016 - Sep 2017

      ✦ Analysed the clinical data from an Exenatide-Parkinson’s disease (PD) phase II clinical trial via SPSS Statistics ✦ Inspected patients’ symptoms, diagnoses and motor evaluations in Dr. Thomas Foltynie’s PD clinics ✦ Analysed the clinical data from an Exenatide-Parkinson’s disease (PD) phase II clinical trial via SPSS Statistics ✦ Inspected patients’ symptoms, diagnoses and motor evaluations in Dr. Thomas Foltynie’s PD clinics

  • National Tsing Hua University
    • Taiwan
    • Research Services
    • 700 & Above Employee
    • Research Student
      • Mar 2014 - Jun 2016

      ✦ Awarded 6-month Research Grant from Ministry of Science and Technology ✦ Investigated the interaction between hSERF1a/CG17931 and hTau441 in Drosophila via RNAi knockdown - the knockdown was confirmed by RT-qPCR ✦ Verified the efficacy of Caffeic Acid (CA) drug against hTau441’s cytotoxicity in Drosophila compound eyes ✦ Experienced in Drosophila genetics, TRIzol RNA extraction, RT-qPCR, IF, the operation of bright-field and confocal microscopes ✦ Awarded 6-month Research Grant from Ministry of Science and Technology ✦ Investigated the interaction between hSERF1a/CG17931 and hTau441 in Drosophila via RNAi knockdown - the knockdown was confirmed by RT-qPCR ✦ Verified the efficacy of Caffeic Acid (CA) drug against hTau441’s cytotoxicity in Drosophila compound eyes ✦ Experienced in Drosophila genetics, TRIzol RNA extraction, RT-qPCR, IF, the operation of bright-field and confocal microscopes

  • Academia Sinica, Taiwan
    • Taiwan
    • Higher Education
    • 700 & Above Employee
    • Research Intern
      • Jul 2014 - Aug 2014

      ✦ Investigated the microstructure and aggregation dynamics of human Tau protein ✦ Experienced in fast protein liquid chromatography, western blots, the operation of transmission electron microscope and circular dichroism ✦ Investigated the microstructure and aggregation dynamics of human Tau protein ✦ Experienced in fast protein liquid chromatography, western blots, the operation of transmission electron microscope and circular dichroism

Education

  • University of Oxford
    Doctorate Degree, DPhil Clinical Neurosciences
    2018 - 2022
  • UCL
    Master's Degree, MRes Translational Neurology
    2016 - 2017
  • National Tsing Hua University
    Bachelor's Degree, BSc Life Science
    2012 - 2016
  • Affiliated Senior High School of National Taiwan Normal University (HSNU)
    Senior High School, Natural Sciences
    2009 - 2012

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