Nuria Barquero, DVM, MSc, PhD, ERT
Head of Preclinical Toxicology at ARTHEx Biotech- Claim this Profile
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Bio
Credentials
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European Registered Toxicologist (ERT)
AETOX-EUROTOXDec, 2021- Nov, 2024
Experience
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ARTHEx Biotech
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Spain
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Biotechnology Research
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1 - 100 Employee
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Head of Preclinical Toxicology
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Nov 2021 - Present
Head of Precliclinal Toxicology Main Responsibilities: Provide expert support, guidance and strategy on project safety assessments, with a specific focus on discovery & IND-stage projects. Serve as the key resource for toxicology, providing scientific knowledge and expertise to cross-functional project teams. Develop overall toxicology strategy and plans for lead candidates based on clinical development plan. Oversee preclinical toxicology studies at multiple external Contract Research Organizations (CRO). Design & execute investigative toxicology studies, based upon off & on-target safety profiles of the candidate drugs. Initiate appropriate processes for contract implementation, protocol development, and timeline optimization for toxicology studies. Monitor toxicology studies for appropriate conduct, accuracy and timely execution; audit raw data for accuracy, review draft reports and finalize them as submission-ready documents for regulatory authorities. Proactively respond to study issues and resolve problems with study director. Internal and external communication Prepare verbal and written summaries for internal discussions. Work with the Preclinical Development team to develop optimal strategies to address specific safety issues and partner with project teams. Review and/or author toxicology and/or safety pharmacology sections of various regulatory documents (e.g., pre-IND briefing documents, INDs, IBs etc.) and ensure their regulatory compliance. Represent company at meetings with regulatory agencies.
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QUBE
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Spain
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Biotechnology Research
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1 - 100 Employee
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Senior Study Director - Senior Toxicologist at a CRO
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Nov 2018 - Nov 2021
Project Manager Coordination of complex preclinical packages Provide Scientific support Senior Study Director of Preclinical Toxicity Studies. Mentoring Junior Study Directors Solid experience in designing, conducting, and interpreting non-GLP and GLP preclinical toxicology safety studies under OECD, ICH, OPPTS and EPA guidelines. Skilled in : Regulatory Toxicology Sub-acute and Sub-chronic inhalation studies Dose range finding (DRF) Maximum tolerated dose (MTD) Repeated fixed dose studies in rodent and non-rodent species Prenatal developmental toxicity studies
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Clarivate
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United Kingdom
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Information Services
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700 & Above Employee
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Scientific Medical Writer
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Aug 2014 - Sep 2021
Medical Writer at Thomson Reuters (Now Clarivate Analytics). My role consisted in writing scientific review papers about new drugs on the market or drugs that are in the development process for journals Drugs of Today and Drugs of the Future. Medical Writer at Thomson Reuters (Now Clarivate Analytics). My role consisted in writing scientific review papers about new drugs on the market or drugs that are in the development process for journals Drugs of Today and Drugs of the Future.
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ARQUIMEA Agrotech
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Spain
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Biotechnology Research
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1 - 100 Employee
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Head of Microbiology Fermentation Department
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Sep 2017 - Nov 2018
My role involved the management of a team, development of SOPs and protocols, Quality control management, coordination of production and development of R&D projects regarding the generation of microbial consortium to reduce the environmental toxicity of different pollutants. My role involved the management of a team, development of SOPs and protocols, Quality control management, coordination of production and development of R&D projects regarding the generation of microbial consortium to reduce the environmental toxicity of different pollutants.
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LGC
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United Kingdom
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Biotechnology Research
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700 & Above Employee
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Scientist at a CRO
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Jan 2016 - Sep 2017
Project manager duties such as, developing Study Plans and Final Reports under GLP and GCP regulations. Development, Optimization and Validation of Immunoassays for Biomarkers detection (preclinical and clinical studies) Project manager duties such as, developing Study Plans and Final Reports under GLP and GCP regulations. Development, Optimization and Validation of Immunoassays for Biomarkers detection (preclinical and clinical studies)
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Freelance
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United Kingdom
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Freelance Scientific Translator. Animal Welfare and Animal Nursing Courses Online Tutor
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Oct 2012 - Dec 2015
Scientific Translator and Tutor of Animal Nursing Online Courses at Animal Jobs Direct. (ABC Awards Level 2 Animal Nursing Assistant Certificate). Scientific Translator and Tutor of Animal Nursing Online Courses at Animal Jobs Direct. (ABC Awards Level 2 Animal Nursing Assistant Certificate).
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Cambridge e-learning Institute
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United Kingdom
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Director of Farm Animal Welfare Courses, Tutor and Translator
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Oct 2012 - Oct 2013
I was responsible for the management of a team of 5 tutors and 3 external examiners, together with the organization of 80 students. This course was specifically designed for the staff of Bayer. I was responsible for the management of a team of 5 tutors and 3 external examiners, together with the organization of 80 students. This course was specifically designed for the staff of Bayer.
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Universidad Complutense de Madrid
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Spain
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Higher Education
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700 & Above Employee
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PhD student
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2009 - Dec 2012
Title : Epidemiologic analysis of the infections by Small Ruminant Lentiviruses (SRLV) and its contribution to the knowledge of the pathogenesis by these viruses. My PhD combined the use of several laboratory techniques with epidemiology and statistical analysis. Using PCR, ELISA together with tissue culture techniques, I explored the diagnosis of Lentiviruses infections. Following the processing of the samples I calculated the prevalence of these infections and risk factors associated to them. Statistical analysis included ordinary logistic regression and multivariable logistic regressions. The results of my studies were published in peer reviewed journals and consisted in 4 different publications.
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Animal Health Trust
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United Kingdom
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Residence in Epidemiology
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Aug 2005 - Nov 2008
During my residence at the AHT I undertook several epidemiologic projects related with horses’ infectious diseases. As part of my residence I achieved an MSc in Veterinary Epidemiology and Public Health. The scholarship programme was based in epidemiology and biostatistics; I was involved in the design of epidemiological studies and conduct of statistical analyses of several projects. This provided me with experience in data management, planning and application of different statistical methods, use of statistical software, writing of statistical reports and contributing to papers for publication. I was involved as well in the planning of clinical trials in horses for the study of efficacy of influenza vaccines. I also worked with techniques as PCR and MLST.
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Yale University School of Medicine
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United States
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Research Services
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700 & Above Employee
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Postdoctoral Research Associate
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Nov 2002 - Mar 2005
During the time I was working at Yale University I conducted studies of ethiology and pathogenesis of Prions diseases, CJD and Scrapie. I developed tissue ,cell culture and animal models of Scrapie and CJD. I worked with different techniques such as Western Blot, Cell Immunostaining, RNA isolation, DNA isolation. Some of my results were published in peer reviewed journal. During the time I was working at Yale University I conducted studies of ethiology and pathogenesis of Prions diseases, CJD and Scrapie. I developed tissue ,cell culture and animal models of Scrapie and CJD. I worked with different techniques such as Western Blot, Cell Immunostaining, RNA isolation, DNA isolation. Some of my results were published in peer reviewed journal.
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Universidad Complutense de Madrid
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Spain
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Higher Education
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700 & Above Employee
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Master Thesis in Diagnostic Methods and Epidemiology of Small Ruminant Lentivirus
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Jun 1999 - Nov 2002
During my Master Thesis Degree, I explored whether milk could provide an appropriate substrate for diagnosing Small Ruminant Lentiviruses (SRLV) infections instead of blood. In addition, I analysed the suitability of different diagnosis test for the diagnosis of these viral infections in both blood and milk. I conducted the first Seroepidemiological survey of Small Ruminants Lentiviruses (SRLVs) in Madrid. My study was based on several experiments, such as a prevalence study using ELISA and PCR on sheep and goat milk samples.
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Education
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2003 - 2005
Yale University School of Medicine
Post-doc, Prion Diseases -
2020 - 2021
University of Barcelona
Postgraduate in Toxicological Evaluation. Application in the Chemical-Pharmaceutical Industry -
Royal Veterinary College, U. of London
MSc, Veterinary Epidemiology and Public Health -
Universidad Complutense de Madrid
PhD, Veterinary Epidemiology and Microbiology -
Universidad Complutense de Madrid
DVM, Veterinary Degree
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