Nathaniel Sherden

VP Chemistry at Octagon Therapeutics
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Contact Information
us****@****om
(386) 825-5501
Location
Boston, Massachusetts, United States, US

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Experience

    • Morocco
    • Biotechnology Research
    • 1 - 100 Employee
    • VP Chemistry
      • Aug 2017 - Present

      Started and lead the Medicinal Chemistry department at Octagon Therapeutics. Started and lead the Medicinal Chemistry department at Octagon Therapeutics.

    • United Kingdom
    • Research Services
    • 200 - 300 Employee
    • Postdoctoral Research Fellow, O’Connor Lab
      • Jul 2011 - Jan 2017

      My primary work at this position was doing gene discovery in medicinal plants via transcriptomics, clustering analysis, and both in vivo and in vitro experiments. This went hand an hand with doing significant amounts of synthetic biology focusing on heterologous pathway reconstitution of pharmacologically relevant secondary plant metabolism. I also preformed a great deal of metabolomics work (untargeted) to assess changes in extremely complex plant metabolisms, both synthetic and… Show more My primary work at this position was doing gene discovery in medicinal plants via transcriptomics, clustering analysis, and both in vivo and in vitro experiments. This went hand an hand with doing significant amounts of synthetic biology focusing on heterologous pathway reconstitution of pharmacologically relevant secondary plant metabolism. I also preformed a great deal of metabolomics work (untargeted) to assess changes in extremely complex plant metabolisms, both synthetic and natural. Additionally I did support work as a resident synthetic organic chemist on numerous other projects that multiple biologist coworkers were leading on. I Assisting with the design and synthesis of small molecules for biological and biochemical projects as well as structural determination and characterization of novel natural and unnatural substrate-derived products. Show less My primary work at this position was doing gene discovery in medicinal plants via transcriptomics, clustering analysis, and both in vivo and in vitro experiments. This went hand an hand with doing significant amounts of synthetic biology focusing on heterologous pathway reconstitution of pharmacologically relevant secondary plant metabolism. I also preformed a great deal of metabolomics work (untargeted) to assess changes in extremely complex plant metabolisms, both synthetic and… Show more My primary work at this position was doing gene discovery in medicinal plants via transcriptomics, clustering analysis, and both in vivo and in vitro experiments. This went hand an hand with doing significant amounts of synthetic biology focusing on heterologous pathway reconstitution of pharmacologically relevant secondary plant metabolism. I also preformed a great deal of metabolomics work (untargeted) to assess changes in extremely complex plant metabolisms, both synthetic and natural. Additionally I did support work as a resident synthetic organic chemist on numerous other projects that multiple biologist coworkers were leading on. I Assisting with the design and synthesis of small molecules for biological and biochemical projects as well as structural determination and characterization of novel natural and unnatural substrate-derived products. Show less

    • United States
    • Higher Education
    • 700 & Above Employee
    • Postdoctoral Research Fellow, O’Connor Lab
      • Mar 2011 - Jul 2011

      Resident synthetic organic chemist in the O’Connor group assisting with the design and synthesis of small molecules for biochemical projects as well as structural determination and characterization of novel natural products. Resident synthetic organic chemist in the O’Connor group assisting with the design and synthesis of small molecules for biochemical projects as well as structural determination and characterization of novel natural products.

    • United States
    • Research Services
    • 700 & Above Employee
    • Graduate Student Research Assistant
      • 2004 - May 2011

      Graduate student research assistant in the Stoltz group, an organic synthesis lab. Conducted investigative organometallic research into the mechanism of metal catalyzed organic transformations in support of organic synthesis and methodology design.

    • Graduate Student Teaching Assistant
      • Sep 2004 - Dec 2008

      Teaching Assistant for a number of different classes ranging from undergraduate introductory general chemistry through undergraduate organic and graduate level total synthesis. Positions required a mixture of preparing problems and lectures for weekly recitation sections, office hours, writing problem sets and exams, grading, monitoring the lab work and safety of students, and giving a few full lectures.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • Jan 2003 - Jul 2004

      Undergraduate research assistant in the Hillhouse group, an organometallic synthesis lab. Conducted organometallic research on on nickel(I) and nickel(II) germyls and germylene complexes with an emphasis on exploratory chemistry examining the chemical properties and behavior for these relatively unknown complexes. Undergraduate research assistant in the Hillhouse group, an organometallic synthesis lab. Conducted organometallic research on on nickel(I) and nickel(II) germyls and germylene complexes with an emphasis on exploratory chemistry examining the chemical properties and behavior for these relatively unknown complexes.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Teaching Assistant
      • Jun 2002 - Jul 2002

      Undergraduate Teaching Assistant for the 4 week long accelerated summer offering of introductory undergraduate organic chemistry. Position involved preparing and giving semiweekly recitation lectures, monitoring lab work and safety of the students, grading, office hours, and offering additional unscheduled meetings and help to students as they deemed necessary.

    • Undergraduate Research Assistant
      • Jan 2001 - Jun 2002

      Undergraduate Research Assistant in the Yang group, an organic synthesis lab. Worked on the synthesis of organic molecules designed to display novel non-linear optical properties.

    • United States
    • Primary and Secondary Education
    • 1 - 100 Employee
    • Student
      • 1996 - 2000

Education

  • Caltech
    PhD, Chemistry (Organometallics)
    2004 - 2010
  • University of Chicago
    BS, Chemistry
    2000 - 2004
  • University of Chicago
    BS, Computer Science
    2000 - 2004

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