Experience

Tiaki Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientist, Biology

  • Mar 2018 - Sep 2021

  Cambridge, Massachusetts, United States Key technical scientist for Tiaki, an early-stage biotech company focused on the development of targets to address the role of neuroinflammation in neurodegenerative disease: • Master rodent organotypic brain slice culture platform to support drug discovery that drove identification of 2 novel targets for further development across CNS diseases • Profile gene expression with Nanostring technology and proprietary software to align proprietary transcriptomic signature from patients to… Show more Key technical scientist for Tiaki, an early-stage biotech company focused on the development of targets to address the role of neuroinflammation in neurodegenerative disease: • Master rodent organotypic brain slice culture platform to support drug discovery that drove identification of 2 novel targets for further development across CNS diseases • Profile gene expression with Nanostring technology and proprietary software to align proprietary transcriptomic signature from patients to discovery platform • Purify and quantitate RNA from slice culture platform • Analyze protein endpoints utilizing ELISA and Western blot techniques for platform secretomics and in support of in vivo studies • Technical support for collaborations with several pharmaceutical companies used for drug discovery decision making • Perform rapid data turnaround and communication to the team to facilitate near real-time decision-making in an extremely fluid and fast-paced environment • Author study reports to facilitate high-level meetings with external stakeholders. • Manage day-to-day logistics of laboratory operations Show less



Pfizer

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Scientist, Biology

  • Aug 2006 - Mar 2018

  Groton, Connecticut, United States Technical scientist responsible for leadership from the bench with in vitro and in vivo assays in neurodegenerative pre-clinical programs: • Point of contact for in vivo studies for mid-stage program targeting lipoprotein for Alzheimer’s disease requiring coordination across departments • Authored several study reports in preparation for drug applications to the FDA • Communicated written data reports and presented data packages to project team • Designed and conducted in vivo… Show more Technical scientist responsible for leadership from the bench with in vitro and in vivo assays in neurodegenerative pre-clinical programs: • Point of contact for in vivo studies for mid-stage program targeting lipoprotein for Alzheimer’s disease requiring coordination across departments • Authored several study reports in preparation for drug applications to the FDA • Communicated written data reports and presented data packages to project team • Designed and conducted in vivo studies in transgenic mice to characterize strains and developed PK/PD relationship to test CNS efficacy of compounds • Developed phenotypic assay for lipoprotein program during early-stage using ELISA and DELFIA platforms, and transferred protocol to high-throughput screening group • Delivered robust in vivo amyloid-β efficacy data for the secretase modulator program to drive the program from lead development to candidate selection • Established robust mouse circadian rhythm assay as the primary pharmacodynamic assay to drive kinase inhibitor program forward • Reviewed and critiqued animal use protocols as a voting member of the IACUC • Mentored Northeastern University co-op student who was hired as a full-time scientist Show less



Rhode Island Department of Health

• United States
• Government Administration
• 300 - 400 Employee

• Environmental Scientist

  • Mar 2005 - Aug 2006

  Providence, Rhode Island, United States • Maintained and calibrated equipment for monitoring ozone, nitrogen oxide, sulfur dioxide, and carbon monoxide levels in air samples at field sites • Performed gas chromatography and mass spectrometry to analyze volatile organics • Enacted quality control procedures as outlined by SOPs



Boston Children's Hospital

• United States
• Hospitals and Health Care
• 700 & Above Employee

• Lab Manager

  • May 2000 - May 2004

  Boston, Massachusetts, United States • Isolated, expanded and maintained new human neural stem cell line • Managed daily activities of lab and monitored inventory • Performed stem cell transplantation into rodent models • Developed tissue culture protocol for new human cell line and trained colleagues